초록

The present invention relates to methods and devices for administration of vaccines and gene therapeutic agents into the intradermal layer of skin.

대표청구항 ▼

What is claimed is: 1. A method for inducing an immune response to a flaviviral antigen in a human subject comprising delivering a vaccine expressing the flaviviral antigen to a subject's skin using a device that targets the intradermal compartment of the subject's skin, wherein the device comprise

What is claimed is: 1. A method for inducing an immune response to a flaviviral antigen in a human subject comprising delivering a vaccine expressing the flaviviral antigen to a subject's skin using a device that targets the intradermal compartment of the subject's skin, wherein the device comprises at least one hollow microneedle that delivers the vaccine to the subject's skin to a depth of between 0.025 mm and 2.0 mm. 2. A kit for use in inducing an immune response to a flaviviral antigen in a subject, said kit comprising: (a) a vaccine expressing the flaviviral antigen; and (b) a device that that targets the intradermal compartment of the subject's skin, wherein the device comprises: (1) at least one microneedle, wherein the microneedle is supported by a hub potion and has a forward tip that extends away from the hub portion; and (2) a limiter portion that surrounds the microneedle and extends away from the hub portion toward the forward tip of the microneedle, wherein the limiter portion comprises a flat skin engaging surface that extends in a plane perpendicular to an axis of the microneedle, the forward tip of the microneedle extending beyond the skin engaging surface at a distance of between 0.5 mm and 2.0 mm. 3. The method of claim 1, wherein the vaccine is a chimeric Japanese Encephalitis vaccine. 4. The method of claim 3, wherein the chimeric Japanese Encephalitis vaccine is JE SA14-14-2. 5. The kit of claim 2, wherein the vaccine is a chimeric Japanese Encephalitis vaccine. 6. The kit of claim 5, wherein the chimeric Japanese Encephalitis vaccine is JE SA14-14-2.