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Method of identifying a PPARgamma-agonist compound having a decreased likelihood of inducing dose-dependent peripheral edema

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • G01N-033/53
출원번호 US-0483290 (2006-07-07)
등록번호 US-7482124 (2009-01-27)
발명자 / 주소
  • Ranade,Koustubh
  • Delmonte,Terrye Aigeldinger
  • Geese,William J.
출원인 / 주소
  • Bristol Myers Squibb Company
대리인 / 주소
    D'Amico,Stephen C.
인용정보 피인용 횟수 : 0  인용 특허 : 71

초록

The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist induced edema. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus p

대표청구항

What is claimed is: 1. A method of identifying a PPARgamma-agonist compound having a decreased likelihood of inducing dose-dependent peripheral edema in a patient comprising the step of: (a) incubating mammalian cells that endogenously express renin with a test compound; and (b) measuring the level

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