A medical device that is at least partially formed of a novel metal alloy, which novel metal alloy improves the physical properties of the medical device.
대표청구항▼
We claim: 1. A medical device that is at least partially formed of a metal alloy which improves the strength and ductility of the medical device, said metal alloy including at least about 95 weight percent of a solid solution, said metal alloy including 45-50 weight percent rhenium and 50-55 weight
We claim: 1. A medical device that is at least partially formed of a metal alloy which improves the strength and ductility of the medical device, said metal alloy including at least about 95 weight percent of a solid solution, said metal alloy including 45-50 weight percent rhenium and 50-55 weight percent molybdenum, said metal alloy including carbon and oxygen and having a carbon to oxygen atomic ratio of at least about 2:1, said metal alloy having a nitrogen content of less than about 20 ppm, a carbon content of less than about 150 ppm, and an oxygen content of less than about 50 ppm, said metal alloy having an average yield strength of at least about 98 ksi and an average ultimate tensile strength of at least about 100 ksi, said metal alloy having an average grain size of over 5 ASTM, said metal alloy having an average tensile elongation of at least about 25% said metal alloy having a carbon to nitrogen atomic ratio of less than about 40:1 and an oxygen to nitrogen atomic ratio of less than about 30:1, at least one region of said medical device includes at least one biological agent. 2. The medical device as defined in claim 1, wherein said metal alloy including at least about 99 weight percent of a solid solution, said solid solution including at least 95 weight percent rhenium and molybdenum and an additional metal, said additional metal constituting less than about 2 weight percent of said solid solution said additional metal selected from the group consisting of titanium, yttrium, zirconium, or mixtures thereof. 3. The medical device as defined in claim 1, wherein said metal alloy metal alloy includes a plurality of second phase particles, said second phase particles including carbides, carbo-nitrides, oxides or mixtures thereof. 4. The medical device as defined in claim 1, wherein said metal alloy has an average grain size of over 5-10 ASTM. 5. The medical device as defined in claim 1, wherein said metal alloy has an average density of at least 13 gm/cc. 6. The medical device as defined in claim 1, wherein said metal alloy includes about 46-49 weight percent rhenium and about 51-54 weight percent molybdenum. 7. The medical device as defined in claim 1, wherein said medical device is a stent, graft, valve, screw, nail, rod, PFO device, prosthetic device, sheath, guide wire, balloon catheter, hypotube, catheter, electrophysiology catheter, staple or cutting device. 8. The medical device as defined in claim 1, wherein said at least one biological agent includes trapidil, trapidil derivatives, taxol, taxol derivatives, cytochalasin, cytochalasin derivatives, paclitaxel, paclitaxel derivatives, rapamycin, rapamycin derivatives, GM-CSF, GM-CSF derivatives, and combinations thereof. 9. The medical device as defined in claim 1, wherein at least one region of said medical device includes at least one polymer. 10. The medical device as defined in claim 9, wherein said at least one polymer at least partially coats said at least biological agent, encapsulates said at least biological agent, and combinations thereof. 11. The medical device as defined in claim 10, wherein said at least one polymer controllably releases at least one of said biological agents. 12. The medical device as defined in claim 9, wherein said at least one polymer includes parylene, a parylene derivative, chitosan, a chitosan derivative, PLGA, a PLGA derivative, PLA, a PLA derivative, PEVA, a PEVA derivative, PBMA, a PBMA derivative, POE, a POE derivative, PGA, a PGA derivative, PLLA, a PLLA derivative, PAA, a PAA derivative, PEG, a PEG derivative, or combinations thereof. 13. The medical device as defined in claim 1, wherein said medical device includes at least one micro-structure in an outer surface of said medical device. 14. The medical device as defined in claim 13, wherein said at least one micro-structure is at least partially formed of, includes, or combinations thereof, a material consisting of a polymer, a biological agent, or combinations thereof. 15. The medical device as defined in claim 2, wherein said metal alloy metal alloy includes a plurality of second phase particles, said second phase particles including carbides, carbo-nitrides, oxides, and mixtures thereof. 16. The medical device as defined in claim 15, wherein said metal alloy has an average grain size of about 5-10 ASTM. 17. The medical device as defined in claim 16, wherein said metal alloy has an average density of at least 13 gm/cc. 18. The medical device as defined in claim 17, wherein said metal alloy includes about 46-49 weight percent rhenium and about 51-54 weight percent molybdenum. 19. The medical device as defined in claim 18, wherein at least one region of said medical device includes at least one polymer, said at least one polymer at least partially cost said at least biological agent, encapsulates said at least biological agent, and combinations thereof. 20. The medical device as define in claim 19, wherein said at least one polymer controllably releases at least one of said biological agents. 21. The medical device as defined in claim 18, wherein said medical device includes at least one micro-structure in an outer surface of said medical device. 22. The medical device as defined in claim 21, wherein said at least one micro-structure is at least partially formed of, includes, or combinations thereof, a material consisting of a polymer, a biological agent, and combinations thereof. 23. The medical device as defined in claim 1, wherein said solid solution includes by weight percent: C ≦150 ppm Mo 50-55% O ≦100 ppm N ≦40 ppm Re 45-50% Ti ≦0.5% Y ≦0.1% Zr ≦0.25%. 24. The medical device as defined in claim 17, wherein said solid solution includes by weight percent: C ≦150 ppm Mo 50-55% O ≦100 ppm N ≦40 ppm Re 45-50% Ti ≦0.5% Y ≦0.1% Zr ≦0.25% 25. The medical device as defined in claim 1, wherein said metal alloy including carbon and oxygen and having a carbon to oxygen atomic ratio of about 2.5-10:1. 26. The medical device as defined in claim 18, wherein said metal alloy including carbon and oxygen and having a carbon to oxygen atomic ratio of about 2.5-10:1. 27. The medical device as defined in claim 1, wherein said metal alloy has an average grain size of about 6-9 ASTM. 28. The medical device as defined in claim 18, wherein said metal alloy has an average grain size of about 6-9 ASTM. 29. The medical device as defined in claim 1, wherein said atomic ratio of carbon to oxygen in said metal alloy is less than about 50:1. 30. The medical device as defined in claim 18, wherein said atomic ratio of carbon to oxygen in said metal alloy is less than about 50:1. 31. The medical device as defined in claim 1, wherein said metal alloy includes titanium. 32. The medical device as defined in claim 18, wherein said metal alloy includes titanium. 33. The medical device as defined in claim 31, wherein said metal alloy includes titanium and zirconium, said titanium and zirconium having a weight ratio of about 1.2-5:1. 34. The medical device as defined in claim 32, wherein said metal alloy includes titanium and zirconium, said titanium and zirconium having a weight ratio of about 1.2-5:1.
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