Method for treating congestive heart failure and other disorders
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/16
C07K-007/08
C07K-007/00
출원번호
US-0054072
(2005-02-08)
등록번호
US-7494979
(2009-02-24)
발명자
/ 주소
Currie,Mark G.
Mahajan Miklos,Shalina
Sun,Li Jing
Kurtz,Caroline
출원인 / 주소
Ironwood Pharmaceuticals, Inc.
대리인 / 주소
Fish & Richardson P.C.
인용정보
피인용 횟수 :
22인용 특허 :
8
초록▼
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bo
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
대표청구항▼
What is claimed is: 1. A method for treating a disorder selected from the groups consisting of congestive heart failure, hypertension, salt dependent high blood pressure, hepatic edema and liver cirrhosis, the method comprising administering to a subject in need thereof a composition comprising a p
What is claimed is: 1. A method for treating a disorder selected from the groups consisting of congestive heart failure, hypertension, salt dependent high blood pressure, hepatic edema and liver cirrhosis, the method comprising administering to a subject in need thereof a composition comprising a polypeptide comprising the amino acid sequence: Xaa1 Xaa2 Xaa3 Cys4 Xaa5 Xaa6 Xaa7 Xaa8 Xaa9 Xaa10 Xaa11 Cys12 Xaa13 Xaa14 Xaa15 Xaa16 (SEQ ID NO:1) or a pharmaceutically acceptable salt thereof, wherein: Xaa1 is Ser, Asn, Tyr, Ala, Gln, Pro, Lys, Gly, or Thr, or is missing; Xaa2 is His, Asp, Glu, Ala, Ser, Asn, Gly, or is missing; Xaa3 is Thr, Asp, Ser, Glu, Pro, Val or Leu; Xaa5 is Asp, Ile or Glu; Xaa6 is Ile, Trp or Leu; Xaa7 is Cys, Ser, or Tyr; Xaa8 is Ala, Val, Thr, Ile, Met or is missing; Xaa9 is Phe, Tyr, Asn or Trp; Xaa10 is Ala, Val, Met, Thr or Ile; Xaa11 is Ala or Val; Xaa13 is Ala or Thr; Xaa14 is Gly, Ala or Ser; Xaa15 is Cys, Tyr or is missing; and Xaa16 is His, Leu or Ser. 2. The method of claim 1 wherein the polypeptide comprises the amino acid sequence Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO:44) or a pharmaceutically acceptable salt thereof. 3. The method of claim 1 wherein the composition comprises a pharmaceutically acceptable carrier and the polypeptide comprising SEQ ID NO:1 or a pharmaceutically acceptable salt thereof. 4. The method of claim 1 wherein the disorder is congestive heart failure. 5. A method for treating congestive heart failure comprising administering to a subject in need thereof a composition comprising a polypeptide comprising the amino acid sequence Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO:44) or a pharmaceutically acceptable salt thereof. 6. The method of claim 1 wherein the polypeptide consists of the aminio acid sequence of SEQ ID NO: 1 or a pharmaceutically acceptable acceptable salt thereof. 7. The method of claim 2 wherein the polypeptide consists of the amino acid sequence Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO:44) or a pharmaceutically acceptable salt thereof. 8. The method of claim 3 wherein the composition comprises a pharmaceutically acceptable carrier and a polypeptide consisting of the amino acid sequence of SEQ ID NO:1 or a pharmaceutically acceptable salt thereof. 9. The method of claim 6 wherein the disorder is congestive heart failure. 10. The method of claim 5 wherein the polypeptide consists of the amino acid sequence Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO:44) or a pharmaceutically acceptable salt thereof. 11. The method of claim 1 wherein the polypeptide comprises the amino acid sequence Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO:73) or a pharmaceutically acceptable salt thereof. 12. The method of claim 11 wherein the polypeptide consists of the amino acid sequence Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO:73) or a pharmaceutically acceptable salt thereof. 13. A method for treating congestive heart failure comprising administering to a subject in need thereof a composition comprising a polypeptide comprising the amino acid sequence Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO:73) or a pharmaceutically acceptable salt thereof. 14. The method of claim 13 wherein the polypeptide consists of the amino acid sequence Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu (SEQ ID NO:73) or a pharmaceutically acceptable salt thereof.
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