[특허]Medicaments

Medicaments 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/12 A61K-009/14 A61K-009/00
출원번호	US-0994318 (2004-11-23)
등록번호	US-7498020 (2009-03-03)
우선권정보	GB-9126378.0(1991-12-12); GB-9126405.1(1991-12-12); GB-9202522.0(1992-02-06)
발명자 / 주소	Akehurst,Rachel Ann Taylor,Anthony James Wyatt,David Andrew
출원인 / 주소	Glaxo Group Limited
대리인 / 주소	Bacon & Thomas PLLC
인용정보	피인용 횟수 : 0 인용 특허 : 47

초록 ▼

This invention relates to aerosol formulations of use for the administration of medicaments by inhalation, in particular a pharmaceutical aerosol formulation which comprises particulate salbutamol and physiologically acceptable salts and solvates thereof and a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant, which formulation is substantially free of surfactant. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation as defined is also described.

대표청구항 ▼

We claim: 1. A process for preparing a filled pharmaceutical aerosol canister which comprises: (a) preparing a pharmaceutical aerosol formulation for use for the administration of medicaments by inhalation wherein the formulation comprises particulate fluticasone propionate as medicament and 1,1,1,2-tetrafluoroethane as propellant, which formulation is free of surfactant and chlorofluorcarbons; and (b) filling the formulation into a canister. 2. A process according to claim 1 wherein the formulation of step (a) is substantially free of alcohols. 3. A process according to claim 1 wherein the formulation of step (a) consists essentially of particulate fluticasone propionate as medicament and 1,1,1,2-tetrafluoroethane as propellant. 4. A process according to claim 1 wherein the formulation of step (a) consists of particulate fluticasone propionate as medicament and 1,1,1,2-tetrafluoroethane as propellant. 5. A process according to claim 1 wherein the formulation of step (a) contains particulate salmeterol or a physiologically acceptable salt thereof in combination with particulate fluticasone propionate as medicament. 6. A process according to claim 5 wherein the formulation of step (a) contains salmeterol xinafoate in combination with fluticasone propionate as medicament. 7. A process according to claim 1 wherein the formulation of step (a) consists essentially of particulate salmeterol or a physiologically acceptable salt thereof in combination with particulate fluticasone propionate as medicament and 1,1,1,2-tetrafluoroethane as propellant. 8. A process according to claim 1 wherein the formulation of step (a) consists of particulate salmeterol or a physiologically acceptable salt thereof in combination with particulate fluticasone propionate as medicament and 1,1,1,2-tetrafluoroethane as propellant. 9. A process according to claim 7 wherein salmeterol is present as its xinafoate salt. 10. A process according to claim 8 wherein salmeterol is present as its xinafoate salt. 11. A process according to claim 1 wherein in the formulation of step (a) the medicament is present in an amount of 0.005-5% w/w relative to the total weight of the formulation. 12. A process according to claim 11 wherein in the formulation of step (a) the medicament is present in an amount of 0.01-1% w/w relative to the total weight of the formulation. 13. A process according to claim 1 wherein in step (a) the formulation is prepared by dispersing the medicament in the propellant. 14. A process according to claim 1 wherein the canister is an aluminium can which is closed with a metering valve. 15. A process according to claim 14 wherein in step (b) an aliquot of the formulation is filled through the metering valve into the canister. 16. A process according to claim 1 which comprises: (a) adding particulate medicament to a charge vessel and pressure filling the liquefied propellant through the charge vessel into a manufacturing vessel to form a drug suspension; (b) mixing the drug suspension before recirculation to a filling machine; and (c) filling an aliquot of the drug suspension through the metering valve into a canister, said canister being formed of an aluminium can to which a metering valve has been crimped.

이 특허에 인용된 특허 (47)

Johnson Keith A. (Holmes Beach FL), Aerosol drug formulations.
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Taylor Anthony James,GBX ; Neale Philip John,GBX, Aerosol formulation containing beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant.
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Akehurst Rachel Ann,GBX ; Taylor Anthony James,GBX ; Wyatt David Andrew,GBX, Aerosol formulations containing P134A and/or P227 and particulate medicament.
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Akehurst Rachel Ann,GB3 ; Taylor Anthony James,GB3 ; Wyatt David Andrew,GB3, Aerosol formulations containing P134a and particulate medicament.
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Akehurst Rachel Ann,GBX ; Taylor Anthony James,GBX ; Wyatt David Andrew,GBX, Aerosol formulations containing P134a and particulate medicament.
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Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Aerosol formulations containing P134a and particulate medicaments.
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Akehurst Rachel Ann,GB3 ; Taylor Anthony James,GB3 ; Wyatt David Andrew,GB3, Aerosol formulations containing P134a and particulate medicaments.
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Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Aerosol formulations containing P134a and salbutamol.
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Taylor Anthony James,GB3 ; Neale Philip John,GB3, Aerosol formulations containing beclomethasone dipropionate-1, 1, 1, 2-tetrafluoroethane solvate.
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Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Aerosol formulations containing propellant 134a and fluticasone propionate.
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Evans Richard M. (Westwood MA) Farr Stephen J. (Llandaf GB7), Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol.
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Julianne Fassberg ; Joel A. Sequeira ; Imtiaz A. Chaudry ; Michael Kopcha, Aerosol formulations of albuterol and 1,1,1,2-tetrafluoroethane.
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Gilroy Gordon C. (R.F.D. 2 ; Darby La. Bedford NH 03102), Aerosol package having compressed gas propellant and vapor tap of minute size.
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Bargigia Gianangelo (Milan ITX) Caporiccio Gerardo (Milan ITX) Carniselli Giuliano (Milan ITX), Aerosol propellant compositions.
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Phillipps Gordon H. (Wembley GB2) Bain Brian M. (Chalfont St. Peter GB2) Steeples Ian P. (Ruislip Manor GB2) Williamson Christopher (Cobham GB2), Androstane carbothioates.
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Phillipps Gordon H. (Wembley GB2) Bain Brian M. (Chalfont St. Peter GB2) Laing Stuart B. (Harrow GB2), Androstane carbothioic acids.
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Phillipps Gordon H. (Wembley GB2) Bain Brian M. (Chalfont St. Peter GB2) Laing Stuart B. (Harrow GB2), Androstane carbothioic acids.
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Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Canister containing aerosol formulations containing P134a and particulate medicaments.
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Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Canister containing aerosol formulations containing P134a and particulate medicaments.
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Akehurst Rachel Ann,GB3 ; Taylor Anthony James,GB3 ; Wyatt David Andrew,GB3, Canister containing aerosol formulations containing P134a and particulate medicaments.
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Akehurst Rachel Ann (Ware GB3) Taylor Anthony James (Ware GB3) Wyatt David Andrew (Ware GB3), Canisters containing aerosol formulations containing P134a and fluticasone propionate.
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Brown Kenneth (East Leake GB2), Composition for treating asthma.
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Jinks Philip A. (Mountsorrel GB3) Bell Alexander (Chilwell GB3) Fischer Franz X. (Riehen CHX), Drug-containing chlorofluorocarbon aerosol propellent formulations.
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Byron Peter R. (Richmond) Dalby Richard N. (Richmond VA), Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content.
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Dalby Richard N. (Richmond) Byron Peter R. (Richmond VA), Formulations for delivery of beclomethasone diproprionate by metered dose inhalers containing no chlorofluorocarbon prop.
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Byron Peter R. (Richmond VA) Dalby Richard N. (Richmond VA), Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content.
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Palmer James B. D. (Greenford GBX), Medicaments.
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Neale Philip John (Ware GB3) Taylor Anthony James (Ware GB3), Medicaments for treating respiratory disorders.
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Purewal Tarlochan S. (Leamington Spa GB2) Greenleaf David J. (Loughborough GB2), Medicinal aerosol formulations.
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Purewal Tarlochan S. (Leamington Spa GB2) Greenleaf David J. (Loughborough GB2), Medicinal aerosol formulations.
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Purewal Tarlochan S. (Leamington Spa GB2) Greenleaf David J. (Loughborough GB2), Medicinal aerosol formulations.
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Purewal Tarlochan S. (Leamington Spa GB2) Greenleaf David J. (Loughborough GB2), Medicinal aerosol formulations.
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Purewal Tarlochan S. (Leamington Spa GB2) Greenleaf David J. (Loughborough GB2), Medicinal aerosol formulations.
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Purewal Tarlochan S. (Leamington Spa GB2) Greenleaf David J. (Loughborough GB2), Medicinal aerosol formulations.
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Purewal Tarlochan S. (Leamington Spa GB2) Greenleaf David J. (Loughborough GB2), Medicinal aerosol formulations.
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Purewal Tarlochan S.,GB2 ; Greenleaf David J.,GB2, Medicinal aerosol formulations.
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Purewal Tarlochan S.,GB2 ; Greenleaf David J.,GB2, Medicinal aerosol formulations.
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Purewal Tarlochan S.,GB2 ; Greenleaf David J.,GB2, Medicinal aerosol formulations.
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Greenleaf David J. (Loughborough GB3) Purewal Tarlochan S. (Leamington Spa GB3) Jinks Philip A. (Mount Sorrel GB3), Method for preparing medicinal aerosol formulation containing coated medicament.
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Fassberg, Julianne; Sequeira, Joel A.; Chaudry, Imtiaz A.; Kopcha, Michael, Non-chlorofluorocarbon aerosol formulations.
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Jinks Philip A. (Mountsorrel GB3), Physically modified beclomethasone dipropionate suitable for use in aerosols.
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Heiskel Elmar (Dreieich DEX) Schmieder Wilfred (Hofheim am Taunus DEX), Pressurized-gas pack and propellant for aerosols.
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Tanskanen Paavo T. (Kuopio FIX), Process for the preparation of a mixture of an anti-inflammatory steroid and a fluoro-chloro-hydrocarbon to be used as a.
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Cook Peter Barry (Standon EN) Hunt John Harold (Theydon Bois EN), Steroidal aerosol compositions and process for the preparation thereof.
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Schultz, Robert K.; Schultz, David W.; Oliver, Martin J.; Moris, Robert A.; Jinks, Philip A., Suspension aerosol formulations.
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Schultz Robert K. (Shoreview MN) Quessy Stephen N. (St. Paul MN), Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations.
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Spitzer ; Joseph George ; Small ; Marvin ; Osipow ; Lloyd I. ; Marra ; D orothea C., Vapor tap valve for aerosol containers used with flammable propellants.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
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