IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0314557
(2005-12-21)
|
등록번호 |
US-7501179
(2009-03-10)
|
발명자
/ 주소 |
- Song,Young Ho
- Welch,Eric D.
- Bluni,Scott T.
|
출원인 / 주소 |
- Boston Scientific SciMed, Inc.
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
10 인용 특허 :
321 |
초록
Block copolymer particles, and related compositions and methods, are disclosed.
대표청구항
▼
What is claimed is: 1. A particle, comprising: a biocompatible block copolymer including at least one first block having a glass transition temperature of at most 37�� C. and at least one second block having a glass transition temperature of greater than 37�� C., wherein the at least one first bloc
What is claimed is: 1. A particle, comprising: a biocompatible block copolymer including at least one first block having a glass transition temperature of at most 37�� C. and at least one second block having a glass transition temperature of greater than 37�� C., wherein the at least one first block comprises at least one isobutylene monomer and the particle has a diameter that is selected from the group consisting of less than about 100 microns, from about 300 microns to about 500 microns, from about 700 microns to about 900 microns, and from about 1,000 microns to about 1,200 microns. 2. The particle of claim 1, wherein the particle has a diameter of less than about 100 microns. 3. The particle of claim 1, wherein the particle has a diameter of from about 300 microns to about 500 microns. 4. The particle of claim 1, wherein the particle has a diameter of from about 700 microns to about 900 microns. 5. The particle of claim 1, wherein the particle has a diameter of from about 1,000 microns to about 1,200 microns. 6. The particle of claim 1, wherein the at least one second block comprises at least one block selected from the group consisting of vinyl aromatic blocks, methacrylate blocks, and combinations thereof. 7. The particle of claim 1, wherein the at least one second block comprises at least one monomer selected from the group consisting of styrene, α-methylstyrene, and combinations thereof. 8. The particle of claim 1, wherein the block copolymer has the formula X-(AB)n, A comprises the at least one first block, A is a isobutylene block, B comprises the at least one second block, B is a vinyl aromatic block or a methacrylate block, n is a positive whole number, and X is an initiator. 9. The particle of claim 8, wherein B is a methacrylate block. 10. The particle of claim 9, wherein B comprises at least one monomer selected from the group consisting of methylmethacrylate, ethylmethacrylate, hydroxyethyl methacrylate, and combinations thereof. 11. The particle of claim 8, wherein B is a vinyl aromatic block. 12. The particle of claim 11, wherein the at least one vinyl aromatic block comprises at least one monomer selected from the group consisting of styrene, α-methylstyrene, and combinations thereof. 13. The particle of claim 1, further comprising a therapeutic agent. 14. The particle of claim 1, wherein the block copolymer forms a coating on the particle. 15. The particle of claim 1, further comprising a bioabsorbable material. 16. The particle of claim 1, further comprising a hydrogel. 17. The particle of claim 1, wherein the block copolymer has the formula BAB or ABA, in which A is the at least one first block and B is the at least one second block. 18. The particle of claim 1, wherein the block copolymer has the formula has the formula B(AB)n or A(BA)n, in which A is the at least one first block, B is the at least one second block, and n is a positive whole number. 19. The particle of claim 1, further comprising a second polymer. 20. The particle of claim 19, wherein the second polymer is blended with the block copolymer. 21. The particle of claim 19, wherein the second polymer comprises a second block copolymer. 22. A particle, comprising: a biocompatible block copolymer including at least one first block having a glass transition temperature of at most 37�� C. and at least one second block having a glass transition temperature of greater than 37�� C., wherein the at least one first block comprises at least one isobutylene monomer and the particle has a diameter of about 1,050 microns or more. 23. The particle of claim 22, wherein the particle has a diameter of about 1,070 microns or more. 24. The particle of claim 22, wherein the particle has a diameter of about 1,090 microns or more. 25. The particle of claim 22, wherein the particle has a diameter of about 1,100 microns or more. 26. The particle of claim 22, wherein the particle has a diameter of about 1,150 microns or more. 27. A particle, comprising: a matrix comprising a biocompatible block copolymer including at least one first block having a glass transition temperature of at most 37�� C. and at least one second block having a glass transition temperature of greater than 37�� C.; and at least one sub-particle that is at least partially disposed within the matrix, wherein the at least one first block comprises at least one isobutylene monomer and the particle has a diameter that is selected from the group consisting of less than about 100 microns, from about 300 microns to about 500 microns, from about 700 microns to about 900 microns, and from about 1,000 microns to about 1,200 microns. 28. The particle of claim 27, wherein the at least one sub-particle comprises a plurality of sub-particles. 29. The particle of claim 27, further comprising a first therapeutic agent. 30. The particle of claim 29, further comprising a second therapeutic agent that is different from the first therapeutic agent. 31. A particle, comprising: a matrix comprising a biocompatible block copolymer including at least one first block having a glass transition temperature of at most 37�� C. and at least one second block having a glass transition temperature of greater than 37�� C.; and at least one sub-particle that is at least partially disposed within the matrix, wherein the at least one first block comprises at least one isobutylene monomer and the particle has a diameter of about 1,050 microns or more. 32. The particle of claim 1, wherein the block copolymer comprises styrene-isobutylene-styrene. 33. The particle of claim 22, wherein the block copolymer comprises styrene-isobutylene-styrene. 34. The particle of claim 27, wherein the block copolymer comprises styrene-isobutylene-styrene. 35. The particle of claim 31, wherein the block copolymer comprises styrene-isobutylene-styrene.
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