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System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61B-005/0468
  • A61B-005/0452
출원번호 US-0043612 (2005-01-25)
등록번호 US-7502644 (2009-03-10)
발명자 / 주소
  • Gill,Jong
  • Boileau,Peter
  • Bharmi,Rupinder
  • Min,Xiaoyi
  • Florio,Joseph J.
  • Benser,Michael
  • Bornzin,Gene A.
출원인 / 주소
  • Pacesetter, Inc.
인용정보 피인용 횟수 : 45  인용 특허 : 48

초록

Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment ele

대표청구항

What is claimed is: 1. A method for use with an implantable medical device for detecting cardiac ischemia in a patient in which the device is implanted, the method comprising: tracking repolarization peak-based intervals representative of intervals between depolarization events and peaks of corresp

이 특허에 인용된 특허 (48)

  1. Siegel John H. (Baltimore MD) Nikias Chrysostomos L. (Needham MA), Advanced signal processing methodology for the detection, localization and quantification of acute myocardial ischemia.
  2. Collins Kenneth A. (Neutral Bay AUX), Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy.
  3. Lander Paul ; Gomis Pedro,VEX, Detecting abnormal activation of heart.
  4. Snell Jeffery D., Distributed network system for use with implantable medical devices.
  5. Gene A. Bornzin ; Laurence S. Sloman ; Peter Boileau ; Joseph J. Florio, Implanatable cardiac stimulation device and method for prolonging atrial refractoriness.
  6. Nappholz Tibor A. (Englewood CO) Hursta William N. (Littleton CO) Dawson Albert K. (Denver CO) Steinhaus Bruce M. (Parker CO), Implantable ambulatory electrocardiogram monitor.
  7. Yomtov Barry M. (Bellevue WA) Kreyenhagen Paul E. (Bellevue WA), Implantable cardiac patient monitor.
  8. Kroll,Mark W., Implantable cardiac stimulation device and method for detecting asymptomatic diabetes.
  9. Kroll,Mark W.; Brewer,James E.; Clem,Lisa M., Implantable cardiac stimulation device and method that discriminates between and treats atrial tachycardia and atrial fibrillation.
  10. Poore, John W.; Bradley, Kerry; Sloman, Laurence S.; Bornzin, Gene A.; Florio, Joseph J., Implantable cardiac stimulation system and method for automatic capture verification calibration.
  11. Obel Israel W. P. (Johannesburg ZAX) Bourgeois Ivan (Verviers BEX), Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload.
  12. Fischell Robert E. ; Fischell David R. ; Fischell Tim A., Implantable electronic system with acute myocardial infarction detection and patient warning capabilities.
  13. Ekwall Christer,SEX, Implantable heart stimulator.
  14. Mathson Goran,SEX, Implantable heart stimulator with a maximum stimulation rate that is adjusted dependent on ischemia detection.
  15. Kramer George C. ; Jenkinson Joel P. ; Castaldo Domenico N., Implantable intraosseous device for rapid vascular access.
  16. Ekwall Christer,SEX ; Noren Kjell,SEX, Implantable ischemia detector and implantable stimulator employing same.
  17. Deno,D. Curtis; Havel,William J.; Bennett,Tommy D.; Stein,Paul M.; Euler,David E., Implantable medical device for treating cardiac mechanical dysfunction by electrical stimulation.
  18. Lord Peter C. (Valencia CA) Schultz John R. (Burbank CA) Powell David G. (South Pasadena CA), Implantable medication infusion pump including self-contained acoustic fault detection apparatus.
  19. Ananth Natarajan ; Nitish V. Thakor, Implantable myocardial ischemia detection, indication and action technology.
  20. Adams John M. (Issaquah WA) Alferness Clifton A. (Redmond WA), Implantable myocardial ischemia monitor and related method.
  21. Fischell Robert E. ; Fischell David R. ; Fischell Tim A., Implantable responsive system for sensing and treating acute myocardial infarction.
  22. Robert Stadler ; Shannon Nelson, Ischemia detection during non-standard cardiac excitation patterns.
  23. Ekwall Christer,SEX ; Noren Kjell,SEX, Ischemia detector.
  24. Ekwall Christer,SEX ; Nyhlen Christina,SEX, Ischemia detector and heart stimulator provided with such an ischemia detector.
  25. Benser Michael Eric, Method and apparatus for detecting changes in electrocardiogram signals.
  26. Xue Qiuzhen ; Reddy Shankara, Method and apparatus for determining T-wave marker points during QT dispersion analysis.
  27. Stadler Robert ; Nelson Shannon ; Stylos Lee ; Sheldon Todd J., Method and apparatus for filtering electrocardiogram (ECG) signals to remove bad cycle information and for use of physiologic signals determined from said filtered ECG signals.
  28. Boileau,Peter; Barstad,Janice; Bornzin,Gene A.; Bradley,Kerry; Falkenberg,Eric; Florio,Joseph J., Method and apparatus for monitoring drug effects on cardiac electrical signals using an implantable cardiac stimulation device.
  29. Hill,Michael R. S.; King,Gary W.; Mullen,Thomas J.; Zhou,Xiaohong, Method and apparatus to minimize effects of a cardiac insult.
  30. Joseph M. Starobin ; Yuri B. Chernyak, Method and system for evaluating cardiac ischemia.
  31. Stadler Robert ; Nelson Shannon ; Stylos Lee ; Sheldon Todd J., Method for ischemia detection and apparatus for using same.
  32. Murphy Anthony J. (Annandale AUX) Wickham John (Fivedock AUX) Bassin David (Coogee AUX), Method of classifying heart rhythms by analyzing several morphology defining metrics derived for a patient\s QRS complex.
  33. Davis Mark W. (Newbury Park CA), Method of maximizing catheter longevity in an implantable medication infusion system.
  34. van Lake Paul ; Adinolfi David W., Methods and apparatus for storing intracardiac electrograms.
  35. Karlsson Per (Taby SEX) Lundahl Gunilla (Lidingo SEX) Oljemark Michael (Saltsjo-Boo SEX) Ubby Johan (Vaxholm SEX), Myocardial ischemia and infarction analysis and monitoring method and apparatus.
  36. Karlsson Per,SEX ; Lundahl Gunilla,SEX ; Oljemark Michael,SEX ; Ubby Johan,SEX ; Sjogvist Bengt Arne,SEX, Myocardial ischemia and infarction analysis and monitoring method and apparatus.
  37. Verrier Richard L. (Bethesda MD) Nearing Bruce D. (Rockville MD), Non-invasive dynamic tracking of cardiac vulnerability by analysis of T-wave alternans.
  38. Greenhut Saul E. ; Nappholz Tibor A., Pacemaker with improved detection of atrial fibrillation.
  39. Adams Theodore P. (Edina MN), Preemptive cardioversion therapy in an implantable cardioverter defibrillator.
  40. Fischell Robert E. (Silver Spring MD), Programmable control means for providing safe and controlled medication infusion.
  41. Callaghan Frank J. (Miami FL), Rate responsive pacing using the ventricular gradient.
  42. Renirie Alexis C. M.,NLX ; Houben Richard,NLX ; van Leeuwen Frank,NLX, System and method for continuous monitoring of diabetes-related blood constituents.
  43. Gill,Jong; Boileau,Peter; Bharmi,Rupinder; Min,Xiaoyi; Florio,Joseph J.; Benser,Michael; Bornzin,Gene A., System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device.
  44. Gill,Jong; Boileau,Peter; Bharmi,Rupinder; Min,Xiaoyi; Florio,Joseph J.; Benser,Michael; Bornzin,Gene A., System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device.
  45. Houben, Richard; Larik, Vincent, System and method for monitoring and controlling the glycemic state of a patient.
  46. Kroll,Mark W., System and method for monitoring blood glucose levels using an implantable medical device.
  47. Kroll,Mark W., System and method for monitoring blood glucose levels using an implantable medical device.
  48. Snell, Jeffery D.; Poore, John W.; Sholder, Jason A., System and method for remote programming of implantable cardiac stimulation devices.

이 특허를 인용한 특허 (45)

  1. Kovatchev, Boris P.; King, Christopher R., Accuracy of continuous glucose sensors.
  2. McGarraugh, Geoffrey V., Alarm characterization for analyte monitoring devices and systems.
  3. McGarraugh, Geoffrey V., Alarm characterization for analyte monitoring devices and systems.
  4. Budiman, Erwin Satrya; Doniger, Kenneth J.; Dunn, Timothy Christian; Harper, Wesley Scott, Analyte sensor calibration management.
  5. Zhou, Sophia Huai; Costa Ribalta, Alejo; Schluess, Rainer; Wilm, Bernd, Automated identification of culprit coronary artery using anatomically oriented ECG data display.
  6. Taub, Marc Barry; Harper, Wesley Scott; Berman, Glenn Howard; Huang, Jean Mei, Calibration of analyte measurement system.
  7. Hayter, Gary; Budiman, Erwin S., Closed loop control and signal attenuation detection.
  8. McGarraugh, Geoffrey V., Correlation of alternative site blood and interstitial fluid glucose concentrations to venous glucose concentration.
  9. Torgerson, Nathan A., Device site stimulation for notification.
  10. Feldman, Benjamin Jay; Heller, Adam; Kiaie, Namvar, Method and apparatus for detecting false hypoglycemic conditions.
  11. Feldman, Benjamin Jay; Heller, Adam; Kiaie, Namvar, Method and apparatus for detecting false hypoglycemic conditions.
  12. Feldman, Benjamin Jay; Heller, Adam; Kiaie, Namvar, Method and apparatus for detecting false hypoglycemic conditions.
  13. Budiman, Erwin Satrya, Method and apparatus for improving lag correction during in vivo measurement of analyte concentration with analyte concentration variability and range data.
  14. Doniger, Kenneth J.; Berman, Glenn Howard; McGarraugh, Geoffrey V., Method and apparatus for providing notification function in analyte monitoring systems.
  15. Doniger, Kenneth J.; Berman, Glenn Howard; McGarraugh, Geoffrey V., Method and apparatus for providing notification function in analyte monitoring systems.
  16. Doniger, Kenneth J.; Budiman, Erwin Satrya; Hayter, Gary Alan, Method and device for early signal attenuation detection using blood glucose measurements.
  17. Doniger, Kenneth J.; Budiman, Erwin Satrya; Hayter, Gary Alan, Method and device for early signal attenuation detection using blood glucose measurements.
  18. Budiman, Erwin Satrya, Method and device for providing offset model based calibration for analyte sensor.
  19. Budiman, Erwin Satrya, Method and device for providing offset model based calibration for analyte sensor.
  20. Budiman, Erwin Satrya, Method and system for evaluating analyte sensor response characteristics.
  21. Budiman, Erwin S., Method and system for providing analyte monitoring.
  22. Budiman, Erwin S., Method and system for providing analyte monitoring.
  23. Budiman, Erwin Satrya, Method and system for providing analyte monitoring.
  24. Breton, Marc D.; Kovatchev, Boris P.; Budiman, Erwin S.; Doniger, Kenneth J., Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors.
  25. Breton, Marc D.; Kovatchev, Boris P.; Budiman, Erwin Satrya; Doniger, Kenneth J., Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors.
  26. Budiman, Erwin Satrya, Model based variable risk false glucose threshold alarm prevention mechanism.
  27. Budiman, Erwin Satrya, Model based variable risk false glucose threshold alarm prevention mechanism.
  28. Kiaie, Namvar; Cole, Jean-Pierre; Sloan, Mark Kent; Arbogast, Frederic, Multi-function analyte test device and methods therefor.
  29. Budiman, Erwin Satrya, Multi-rate analyte sensor data collection with sample rate configurable signal processing.
  30. Gutfinger, Dan E.; Qu, Fujian; Soriano, Alex; Rooke, Ryan; Nabutovsky, Yelena; Shah, Riddhi; Blomqvist, Andreas, Near field-based systems and methods for assessing impedance and admittance for use with an implantable medical device.
  31. Budiman, Erwin Satrya; Harper, Wesley Scott; Dunn, Timothy Christian, Optimizing analyte sensor calibration.
  32. Budiman, Erwin Satrya; Harper, Wesley Scott; Dunn, Timothy Christian, Optimizing analyte sensor calibration.
  33. Budiman, Erwin Satrya; Hayter, Gary Alan, Sensitivity calibration of in vivo sensors used to measure analyte concentration.
  34. Budiman, Erwin Satrya; Hayter, Gary Alan, Sensitivity calibration of in vivo sensors used to measure analyte concentration.
  35. Budiman, Erwin Satrya; Hayter, Gary Alan, Sensitivity calibration of in vivo sensors used to measure analyte concentration.
  36. Ou, Junli; Budiman, Erwin Satrya, Sensor fault detection using analyte sensor data pattern comparison.
  37. Ke, Chunlei; Gill, Jong; Boileau, Peter, System and method for detecting cardiac ischemia in real-time using a pattern classifier implemented within an implanted medical device.
  38. Min, Xiaoyi; Rosenberg, Stuart; Farazi, Taraneh Ghaffari; Fayram, Timothy A., Systems and methods for controlling neurostimulation of acupuncture sites using an implantable cardiac rhythm management device.
  39. Gutfinger, Dan E.; Qu, Fujian; Soriano, Alex; Rooke, Ryan; Nabutovsky, Yelena; Shah, Riddhi, Systems and methods for estimating left atrial pressure (LAP) in patients with acute mitral valve regurgitation for use by an implantable medical device.
  40. Gutfinger, Dan E.; Qu, Fujian; Soriano, Alex; Rooke, Ryan; Nabutovsky, Yelena; Shah, Riddhi, Systems and methods for exploiting near-field impedance and admittance for use with implantable medical devices.
  41. Park, Euljoon, Systems and methods for use by an implantable medical device for detecting and discriminating stroke and cardiac ischemia using electrocardiac signals and hemodynamic parameters.
  42. Gill, Jong; Bharmi, Rupinder; Karst, Edward; Rooke, Ryan; Shah, Riddhi; Qu, Fujian; Bornzin, Gene A.; Farazi, Taraneh G.; Park, Euljoon, Systems and methods for use by implantable medical devices for detecting and discriminating stroke and cardiac ischemia using electrocardiac signals.
  43. Park, Euljoon, Systems and methods for use with an implantable medical device for detecting stroke based on electrocardiac signals.
  44. Budiman, Erwin S., Systems, devices and methods for managing glucose levels.
  45. Budiman, Erwin Satrya, Systems, devices and methods for managing glucose levels.
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