초록 ▼

A flat plate-shaped probe carrier for carrying probes such as single stranded DNAs, proteins, etc., which are reactive specifically with target substances comprises a plurality of ring bodies arranged substantially in parallel and the external space among the ring bodies is filled with a filler such

A flat plate-shaped probe carrier for carrying probes such as single stranded DNAs, proteins, etc., which are reactive specifically with target substances comprises a plurality of ring bodies arranged substantially in parallel and the external space among the ring bodies is filled with a filler such that the openings of the ring bodies are oriented to the surface of the probe carrier. Each ring body has a region for fixing a probe adapted to be bonded specifically to a target substance on its inner wall. The probe carrier is produced by bundling a plurality of hollow tubular members in parallel, then filling the external space among the bundled hollow members with a filler, and cutting the bundle along a plane intersecting the axial direction of the tubular members. Probes are fixed to the fixing region before or after filling the external space.

대표청구항 ▼

What is claimed is: 1. A method of manufacturing a probe carrier comprising a plurality of ring bodies, wherein the ring bodies have an internal surface, and the internal surface has a region for fixing a probe adapted to be bonded specifically to a target substance, said method comprising: a step

What is claimed is: 1. A method of manufacturing a probe carrier comprising a plurality of ring bodies, wherein the ring bodies have an internal surface, and the internal surface has a region for fixing a probe adapted to be bonded specifically to a target substance, said method comprising: a step of bundling a plurality of hollow tubular members to arrange them substantially in parallel with each other; a step of filling an external space among the bundled hollow tubular members with a filler and solidifying the filler; a step of cutting the bundle of the tubular members filled with the filler along a plane intersecting an axial direction of the tubular members to produce a flat plate-shaped carrier comprising a plurality of ring bodies having respective internal openings; a step of sealing the tubular members at one end before filling the space with the filler; and a step of fixing probes to respective regions for fixing a probe before or after filling the space with the filler, wherein the filler is in a gel state before the step of filling the external space, and the external space is filled with the filler by applying a centrifugal force to the filler making it flow in a sol state, and wherein solidification is completed as the application of the centrifugal force is reduced, but while gyration still takes place. 2. The method according to claim 1, wherein the target substance is a nucleic acid and the probe has a sequence complementary relative to part or all of the base sequence of the nucleic acid and is a single-stranded nucleic acid adapted to be specifically hybridized with the nucleic acid. 3. A method for forming a flat plate-shaped probe carrier comprising the steps of: providing a plurality of tubular members having an inner surface and an outer surface and being sealed at one end; filling an external space among the tubular members with a filler by applying a centrifugal force to the filler so that solidification of the filler is completed as the application of the centrifugal force is reduced, but while gyration still takes place; fixing a probe on the inner surface of the tubular members before or after filling the external space with the filler; and forming the flat plate-shaped probe carrier comprising ring bodies by cutting the tubular members. 4. The method according to claim 3, wherein the ring bodies comprise fiber, glass or resin. 5. The method according to claim 3, wherein the ring bodies comprise a polypropylene film, polyethylene film or cupro-ammonia cellulose regenerated film. 6. The method according to claim 3, wherein the filler comprises polyurethane. 7. The method according to claim 3, wherein the external space is filled so that substantially no said external space is left. 8. The method according to claim 3, wherein the flat plate-shaped probe carrier consists of the bundle of hollow tubes, probes and the filler. 9. The method according to claim 3, wherein the probe is a single-stranded nucleic acid.