Method and apparatus for spray processing of porous medical devices
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B05D-001/02
B05D-001/08
B05D-007/00
B29B-015/10
C23C-004/02
B29D-022/00
B22F-003/115
B22F-003/00
B22F-005/12
A61F-002/06
출원번호
UP-0582703
(2006-10-17)
등록번호
US-7514122
(2009-07-01)
발명자
/ 주소
Kramer, Pamela A.
출원인 / 주소
Advanced Cardiovascular Systems, Inc.
대리인 / 주소
Squire, Sanders & Dempsey L.L.P.
인용정보
피인용 횟수 :
22인용 특허 :
251
초록▼
Thermal spray processing and cold spray processing are utilized to manufacture porous starting materials (such as tube stock, wire and substrate sheets) from biocompatible metals, metal alloys, ceramics and polymers that may be further processed into porous medical devices, such as stents. The spray
Thermal spray processing and cold spray processing are utilized to manufacture porous starting materials (such as tube stock, wire and substrate sheets) from biocompatible metals, metal alloys, ceramics and polymers that may be further processed into porous medical devices, such as stents. The spray processes are also used to form porous coatings on consolidated biocompatible medical devices. The porous substrates and coatings may be used as a reservoir to hold a drug or therapeutic agent for elution in the body. The spray-formed porous substrates and coatings may be functionally graded to allow direct control of drug elution without an additional polymer topcoat. The spray processes are also used to apply the drug or agent to the porous substrate or coating when drug or agent is robust enough to withstand the temperatures and velocities of the spray process with minimal degradation.
대표청구항▼
What is claimed: 1. A method of manufacturing a medical device, comprising: providing a biocompatible material; using a spray process to form a porous substrate from the biocompatible material; and processing the porous substrate into a medical device. 2. The method of claim 1, further comprisin
What is claimed: 1. A method of manufacturing a medical device, comprising: providing a biocompatible material; using a spray process to form a porous substrate from the biocompatible material; and processing the porous substrate into a medical device. 2. The method of claim 1, further comprising applying a therapeutic agent to the porous substrate. 3. The method of claim 2, wherein applying the therapeutic agent to the porous substrate includes selecting the therapeutic agent from the group consisting of antiplatelets, anticoagulants, antifibrins, antiinflammatories, antithrombins, and antiproliferatives. 4. The method of claim 2, wherein applying the therapeutic agent to the porous substrate includes impregnating the porous substrate with paclitaxel. 5. The method of claim 1, wherein providing the biocompatible material includes providing a metal alloy selected from the group consisting of iron-based, cobalt-based and titanium-based alloys. 6. The method of claim 1, wherein processing the porous substrate includes forming a stent. 7. The method of claim 6, further comprising applying a polymer layer on an outer surface of the stent. 8. The method of claim 6, further comprising using a spray process to form a porous layer of the biocompatible materials on an outer surface of the stent. 9. A method of manufacturing a drug eluting stent, comprising: providing a biocompatible material; forming a porous substrate from the biocompatible material, wherein a spray process is used; processing the porous substrate into a porous tube stock; and forming a pattern in the porous tube stock to form a porous stent. 10. The method of claim 9, further comprising applying a therapeutic agent to the porous substrate. 11. The method of claim 10, wherein applying the therapeutic agent to the porous substrate includes selecting the therapeutic agent from the group consisting of antiplatelets, anticoagulants, antifibrins, antiinflammatories, antithrombins, and antiproliferatives. 12. The method of claim 10, wherein applying the therapeutic agent to the porous substrate includes impregnating the porous substrate with paclitaxel. 13. The method of claim 9, wherein providing the biocompatible material includes providing a metal alloy selected from the group consisting of iron-based, cobalt-based and titanium-based alloys. 14. The method of claim 9, further comprising applying a polymer layer on an outer surface of the stent. 15. The method of claim 9, further comprising using a spray process to form a porous layer of the biocompatible material on an outer surface of the stent. 16. A method of coating a medical device, comprising: providing a medical device; providing a coating material; applying the coating material to the medical device by cold spray thermal processing wherein powder particles are introduced into a high pressure gas where both the gas and particles enter a supersonic jet which is directed against the medical device forming a porous coating, and wherein the medical device is selected from the group consisting of a stent, guide wires, lead tips, catheters, and markers; wherein the porous coating is functionally graded, wherein the thickness of the coating on the medical device is varied, and applying a drug to the porous coating on the medical device. 17. The method of claim 16, wherein applying the drug to the porous coating includes selecting the drug from the group consisting of antiplatelets, anticoagulants, antifibrins, antiinflammatories, antithrombins, and antiproliferatives. 18. The method of claim 16, wherein providing the coating material includes providing a metal alloy selected from the group consisting of iron-based, cobalt-based and titanium-based alloys. 19. The method of claim 16, wherein providing the medical device includes forming a stent. 20. A method of manufacturing a medical device, comprising: providing a biocompatible material; and using a spray process to form a porous substrate from the biocompatible material on a medical device, such that the formed porous substrate exhibits a functionally graded coating over at least a portion of the medical device; wherein the using a spray process to form a porous substrate step is such that the formed porous substrate includes a first porous layer having a first density and a second porous layer having a second density greater than the first density. 21. A method of manufacturing a medical device, comprising: providing a biocompatible material; and using a spray process to form a porous substrate from the biocompatible material on a medical device, such that the formed porous substrate exhibits a functionally graded coating over at least a portion of the medical device; wherein the using a spray process to form a porous substrate step is such that different degrees of density and porosity are formed over at least a portion of the medical device. 22. A method of manufacturing a medical device, comprising: providing a biocompatible material; and using a spray process to form a porous substrate from the biocompatible material on a medical device, such that the formed porous substrate exhibits a functionally graded coating over at least a portion of the medical device; further including the step of impregnating the porous substrate with a drug or therapeutic agent. 23. A method of manufacturing a medical device, comprising: providing a biocompatible material; and using a spray process to form a porous substrate from the biocompatible material on a medical device, such that the formed porous substrate exhibits a functionally graded coating over at least a portion of the medical device; further including the step of varying the thickness of the porous substrate. 24. A method of manufacturing a medical device, comprising: providing a biocompatible material; using a spray process to form a porous substrate from the biocompatible material on a base material, such that the formed porous substrate exhibits a functionally graded coating over at least a portion of the medical device; and processing the porous substrate into a medical device.
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이 특허에 인용된 특허 (251)
Stack Richard S. (Chapel Hill NC) Klopovic Zenaida P. (Durham NC), Absorbable stent.
Barone Hector D. (Maza 1869/73 Buenos Aires TX ARX 1240) Palmaz Julio C. (636 Ivy La. San Antonio TX 78209) Parodi Juan C. (Mercedes 4255 Buenos Aires ARX 1419), Aortic graft for repairing an abdominal aortic aneurysm.
Heller Mathias (Winterthur CHX) Fernandez-Aceytuno Alfonso M. (E-Las Palmas de Gran Canaria ESX) Amann Rainer (Riedern am Sand DEX) Hirt Roland (Schaffhausen CHX) Willi Jakob (Hori CHX), Balloon catheter and stent delivery system.
Davidson Daniel F. (Flagstaff AZ) Kovach Larry J. (Flagstaff AZ) Myers David J. (Camp Verde AZ), Catheter guidewire device having a covering of fluoropolymer tape.
Fearnot Neal E. (West Lafayette IN) Kozma Thomas G. (West Lafayette IN) Ragheb Anthony O. (West Lafayette IN) Voorhees William D. (West Lafayette IN), Coated implantable medical device.
Ragheb, Anthony O.; Bates, Brian L.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D.; Gershlick, Anthony H., Coated implantable medical device.
Claude John P. (San Carlos CA) Ingle Frank W. (Palo Alto CA) Hing Paul A. (Redwood City CA), Communication system for linking a medical device with a remote console.
Greco Ralph S. (Princeton NJ) Harvey Richard A. (East Brunswick NJ) Trooskin Stanley Z. (North Brunswick NJ), Drug bonded prosthesis and process for producing same.
Lazarus Harrison M. (324 Tenth Ave. ; #260 Salt Lake City UT 84103) Williams Ronald G. (1313 Sherman Ave. Menlo Park CA 94025) Sterman Wesley D. (2121 Sacramento St. ; #604 San Francisco CA 94109) Pi, Endovascular grafting apparatus, system and method and devices for use therewith.
Dereume Jean-Pierre Georges Emile (Brussels BEX) MacGregor David C. (Miami FL) Pinchuk Leonard (Miami FL), Expandable supportive bifurcated endoluminal grafts.
Alkhimov Anatoly P. (ulitsa Vyazemskogo 2 ; kv. 72 Novosibirsk SUX) Papyrin Anatoly N. (ulitsa Vyazemskogo 2 ; kv. 72 Novosibirsk SUX) Kosarev Vladimir F. (Novosibirsk SUX) Nesterovich Nikolai I. (No, Gas-dynamic spraying method for applying a coating.
Williams Stuart K. (Tucson AZ) Jarrell Bruce E. (Tucson AZ), Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated imp.
Macaulay Patrick E. (Cupertino CA) Wasicek Lawrence D. (Sunnyvale CA) Bayot Alfredo (Newark CA) Klemm Kurt (Santa Clara CA), Intravascular catheter with a nontraumatic distal tip.
Schwartz Robert S. (Rochester MN) Bresnahan John (Rochester MN) Bergman Rebecca M. (North Oaks MN) Coury Arthur J. (St. Paul MN) Lindell Elaine (Blaine MN) Hull Vincent W. (Fridley MN), Intravascular radially expandable stent.
Dinh Linh ; Correa Beren ; Cherkas Paul ; Alvarado Angelica ; Pomerantseva Irina D. ; Thakur Sudha ; Eury Robert ; Froix Michael, Intravascular stent having a coaxial polymer member and end sleeves.
Zenzon Wendy J. (39541 Gallaudet Dr. #1008 Fremont CA 94538) Chee Uriel H. (127 Dolton Ave. San Carlos CA 94030) Eder Joseph C. (364 Marich Way Los Altos CA 94022) Hergenrother Robert (171 Blaisdell , Lubricious flow directed catheter.
Wholey Mark H. (816 Woodland Ave. Pittsburgh PA 15139) Nagurka Mark L. (5370 Melvin St. Pittsburgh PA 15217) Katz Robert S. (33 Dinsmore Ave. ; Apt. 104 Framingham MA 01701), Method and apparatus for dilating blood vessels.
England Garry L. (9 Stone Camp Trail Winona Lake IN 45690) Higgins Joel C. (R.R. 1 ; Box 55 Claypool IN 46510), Method for forming biocompatible components using an isostatic press.
Amon Michael,DEX ; Bolz Armin,DEX ; Mussig Dirk,DEX, Method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants.
Gan-Moog Chow SG; Lynn K. Kurihara ; T. Danny Xiao ; Peter R. Strutt ; Christopher W. Strock ; Raymond A. Zatorski, Nanosize particle coatings made by thermally spraying solution precursor feedstocks.
Raad Isaam (Houston TX) Sherertz Robert (Winston-Salem NC), Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and.
Hoffman Allan S. (King County WA) Garfinkle Andrew (King County WA) Ratner Buddy D. (King County WA) Hanson Stephen R. (San Diego County CA), Plasma gas discharge treatment for improving the biocompatibility of biomaterials.
Tartaglia Joseph M. (Redwood City CA) Loeffler Joseph P. (Mountain View CA) Turnlund Todd H. (Mountain View CA), Polymer film for wrapping a stent structure.
Tartaglia Joseph M. (Redwood City CA) Loeffler Joseph P. (Mountain View CA) Turnlund Todd H. (Mountain View CA), Polymer film for wrapping a stent structure.
Balko Alexander B. (30 Red Barn La. East Greenwich RI 02818) Shah Dhiraj M. (R.D. #1 ; Rte. 43 Rensselaer NY 12144), Process for restoring patency to body vessels.
Vallana Franco (Turin ITX) Arru Pietro (Turin ITX) Santi Marco (Settimo Torinese ITX), Prosthesis of polymeric material coated with biocompatible carbon.
Pryor Raymond J. (Hamilton NZX) Pharoah James F. (Hamilton NZX) Duirs Graham F. (Hamilton NZX), Relates to devices for administering a substance such as a drug or chemical or the like.
Simpson John B. (Menlo Park CA) Robert Edward W. (Cupertino CA), Vascular guiding catheter assembly and vascular dilating catheter assembly and a combination thereof and methods for mak.
Miller, Steven A.; Kumar, Prabhat; Wu, Richard; Sun, Shuwei; Zimmermann, Stefan; Schmidt-Park, Olaf, Fine grained, non banded, refractory metal sputtering targets with a uniformly random crystallographic orientation, method for making such film, and thin film based devices and products made therefrom.
Volchko, Scott Jeffrey; Zimmermann, Stefan; Miller, Steven A.; Stawovy, Michael Thomas, Methods of manufacturing high-strength large-area sputtering targets.
Shekhter, Leonid N.; Miller, Steven A.; Haywiser, Leah F.; Wu, Rong-Chein R., Process for preparing metal powders having low oxygen content, powders so-produced and uses thereof.
Shekhter, Leonid N.; Miller, Steven A.; Haywiser, Leah F.; Wu, Rong-Chein Richard, Process for preparing metal powders having low oxygen content, powders so-produced and uses thereof.
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