The United States of America as represented by the Secretary of the Army
대리인 / 주소
Morgan, Lewis & Bockius LLP
인용정보
피인용 횟수 :
6인용 특허 :
225
초록▼
A vaccine delivered by transcutaneous immunization provides an effective treatment against infections by pathogens such as, for example, enterotoxigenic Escherichia coli (ETEC) and/or for symptoms of diarrheal disease caused thereby. For example, one, two, three, four, five or more antigens derived
A vaccine delivered by transcutaneous immunization provides an effective treatment against infections by pathogens such as, for example, enterotoxigenic Escherichia coli (ETEC) and/or for symptoms of diarrheal disease caused thereby. For example, one, two, three, four, five or more antigens derived from ETEC and capable of inducing an antigen-specific immune response (e.g., toxins, colonization or virulence factors) and one or more optional adjuvant (e.g., whole bacterial ADP-ribosylating exotoxins, B subunits or toxoids thereof, detoxified mutants and derivatives thereof) are used to manufacture vaccines or to induce systemic and/or mucosal immunity.
대표청구항▼
We claim: 1. A method of preventing traveler's diarrhea in a human that is to be subjected to exposure to pathogens causing traveler's diarrhea comprising applying a vaccine transcutaneously to the skin of the human, prior to exposure to pathogens causing traveler's diarrhea, wherein the vaccine co
We claim: 1. A method of preventing traveler's diarrhea in a human that is to be subjected to exposure to pathogens causing traveler's diarrhea comprising applying a vaccine transcutaneously to the skin of the human, prior to exposure to pathogens causing traveler's diarrhea, wherein the vaccine comprises an effective amount of heat-labile enterotoxin of E. coli (LT) to prevent traveler's diarrhea. 2. A method of preventing traveler's diarrhea in a human that is to be subjected to exposure to pathogens causing traveler's diarrhea comprising applying a vaccine transcutaneously to the skin of the human, prior to exposure to pathogens causing traveler's diarrhea, wherein the vaccine comprises an effective amount of heat-labile enterotoxin of E. coli (LT) to treat traveler's diarrhea. 3. The method of claim 1 or 2, wherein the vaccine comprises LT and an adjuvant. 4. The method of claim 3, wherein the adjuvant is an ADP-ribosylating exotoxin or a derivative thereof having adjuvant activity. 5. The method of claim 1 or 2, wherein the vaccine comprises LT and an E. coli colonization factor antigen (CFA). 6. The method of claim 5, wherein the E. coli colonization factor antigen is selected from the group consisting of CFA/I, CS1, CS2, CS 4, CS5, CS6, CS17 and PCF 0166. 7. The method of claim 1, wherein the vaccine comprises LT and heat stable enterotoxin of E. coli (ST). 8. The method of claim 7, wherein the vaccine comprises a carrier or an excipient. 9. The method of claim 7, wherein LT is conjugated to ST. 10. The method of claim 1, wherein the method comprises pretreating the skin prior to administering the vaccine. 11. The method of claim 10, wherein pretreating comprises chemical penetration enhancement, physical penetration enhancement, or both. 12. The method of claim 1 or 2, wherein the vaccine is applied using a patch. 13. The method of claim 12 wherein the vaccine comprises a carrier or an excipient. 14. The method of claim 1, wherein LT is genetically detoxified. 15. The method of claim 1 or 2, wherein LT is a mutant form of the enterotoxin. 16. The method of claim 1 or 2, wherein LT is both an antigen and an adjuvant. 17. The method of claim 16, wherein LT is a mutant form of the enterotoxin.
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이 특허에 인용된 특허 (225)
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