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Hydraulically actuated pump for long duration medicament administration

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61M-037/00
출원번호 UP-0831354 (2004-04-23)
등록번호 US-7530968 (2009-07-01)
발명자 / 주소
  • Gonnelli, Robert R.
출원인 / 주소
  • Valeritas, Inc.
대리인 / 주소
    Treannie, Esq., Lisa M.
인용정보 피인용 횟수 : 48  인용 특허 : 565

초록

Presently disclosed is a hydraulic pump device and use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or

대표청구항

I claim: 1. A hydraulically actuated fluid delivery system for delivery of a liquid medicament, comprising: (a) a fluid storage chamber for storing said liquid medicament, said fluid storage chamber having an output orifice through which said liquid medicament can be expelled; (b) a single expandab

이 특허에 인용된 특허 (565)

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  187. McConnell, Susan; Moberg, Sheldon B., Fluid reservoir piston.
  188. Yap, Darren Y. K.; Gulati, Poonam; Kovelman, Paul H.; Van Antwerp, William P.; Enegren, Bradley J.; Geismar, Eric P.; Hudak, Philip J.; McConnell, Susan; Moberg, Sheldon B., Fluid reservoir piston.
  189. Johnson Jay Gregory ; Hu Jia, Free-flow protection devices and methods.
  190. John J. Mastrototaro ; Todd M. Gross ; John J. Shin, Glucose monitor calibration methods.
  191. K. Collin McIvor ; James L. Cabernoch ; Kevin D. Branch ; Nannette M. Van Antwerp ; Edgardo C. Halili ; John J. Mastrototaro, Glucose sensor package system.
  192. McIvor, K. Collin; Cabernoch, James L.; Branch, Kevin D.; Van Antwerp, Nannette M.; Halili, Edgardo C.; Mastrototaro, John J., Glucose sensor package system.
  193. Marsh ; Jr. Henry C. (Reading MA) Smith Richard A. G. (Relgate Surrey MA GBX) Yeh Chang-Jing G. (Newton MA) Lifter John (Wellesley MA) Freeman Anne M. (Bucks MA GBX) Gosselin Michael L. (Chelsea MA), Glycoform fractions of recombinant soluble complement receptor 1 (sCR1) having extended half-lives in vivo.
  194. Causey, III, James D.; Purvis, Richard E.; Henke, James, Handheld personal data assistant (PDA) with a medical device and method of using the same.
  195. Causey, III, James D.; Purvis, Richard E.; Henke, James L., Handheld personal data assistant (PDA) with a medical device and method of using the same.
  196. Maus Daryl D. (3550 Smuggler Cir. Boulder CO 80303) Tibbitts Scott F. (8060 Niwot Rd. #298 Longmont CO 80503), Heat-activated drug delivery system and thermal actuators therefor.
  197. Maus Daryl D. ; Tibbitts Scott F., Heat-activated drug delivery system and thermal actuators therefor.
  198. Kamen Dean L. (Bedford NH) Faust Valentine (Bow NH), High flow valve.
  199. Shetler, Lance; Moberg, Sheldon B.; Kimball, Dave, Holster.
  200. Ni, Jian; Ruben, Steven M., Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2.
  201. Ni, Jian; Ruben, Steven M., Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2.
  202. Vachon, David J.; Cochran, Brooks B.; Ponder, Bill C., Hydrophilic polymeric material for coating biosensors.
  203. Van Antwerp, William Peter; Decker, Christian C.; Mastrototoro, John J., Hydrophilic, swellable coatings for biosensors.
  204. Ensminger William D., Implantable access devices.
  205. Arzbaecher Robert C. (Chicago IL), Implantable drug delivery apparatus.
  206. Haller Marcus,CHX ; Lammerink Theo S. J.,NLX ; Olij Niels,NLX, Implantable drug infusion device having an improved valve.
  207. Idriss Samir F. (Hyde Park MA), Implantable drug infusion reservoir having fluid impelling resilient foam member.
  208. Melsky Gerald S. (Lexington MA) Enegren Bradley J. (Norfolk MA), Implantable drug infusion system with safe bolus capability.
  209. Colvin, Michael S.; Schulman, Joseph H.; Canfield, Lyle Dean; Shah, Rajiv, Implantable enzyme-based monitoring systems adapted for long term use.
  210. Portner Peer M. (Kensington CA) Jassawalla Jal S. (San Francisco CA), Implantable infusion device.
  211. Portner Peer M. (Kensington CA) Jassawalla Jal S. (San Francisco CA), Implantable infusion device.
  212. Lord, Peter C.; Brandt, William A.; Gibson, Scott R., Implantable infusion device and reservoir for same.
  213. Hooper, Sandra Marie; Wigness, Bruce David; Blischak, Brian Russell, Implantable infusion pump.
  214. Slettenmark Bruno,SEX, Implantable infusion system with a neutral pressure medication container.
  215. Kramer George C. ; Jenkinson Joel P. ; Castaldo Domenico N., Implantable intraosseous device for rapid vascular access.
  216. Kramer George C. ; Jenkinson Joel P. ; Castaldo Domenico N., Implantable intraosseous device for rapid vascular access.
  217. Srisathapat Chad (Sun Valley CA) Indravudh Virote (Saugus CA), Implantable medication infusion pump with discharge side port.
  218. Crothall Katherine D., Implantable sensor and system for in vivo measurement and control of fluid constituent levels.
  219. Sun Xiaoguang ; Joseph Jeffrey I., Implantable sensor and system for measurement and control of blood constituent levels.
  220. Sun Xiaoguong ; Joseph Jeffrey I. ; Crothall Katherine D., Implantable sensor and system for measurement and control of blood constituent levels.
  221. Morgan, Wayne A.; Choy, David; Gord, John C.; Shah, Rajiv, Implantable sensor electrodes and electronic circuitry.
  222. Reinicke Robert H. (Mission Viejo CA) Yamato Lance M. (Rancho Palos Verdes CA), Implanted medication infusion device.
  223. Clyde Nason ; William H. Stutz, Jr., Incremental motion pump mechanisms powered by shape memory alloy wire or the like.
  224. Van Antwerp William P., Indwelling catheter with stable enzyme coating.
  225. Van Antwerp William P. (Westchester CA), Indwelling catheter with stable enzyme coating.
  226. Van Antwerp William P. (Westchester CA), Indwelling catheter with stable enzyme coating.
  227. Kamen Dean L. (46 Gage Rd. Bedford NH 03102), Infiltration detection system using pressure measurement.
  228. Kamen Dean L. (Bedford NH) Faust Valentine (Bow NH), Inflation control system.
  229. Sampson Edward J. (Concord MA), Infusate injection apparatus.
  230. Prosl Frank R. (Duxbury MA) Sampson Edward J. (Carlisle MA), Infusate pump.
  231. Tucker Elton M. (Medfield MA) Prosl Frank R. (Duxbury MA), Infusion apparatus and method.
  232. Tucker Elton M. (Medfield MA) Prosl Frank R. (Duxbury MA), Infusion apparatus and method.
  233. Gray, John F.; Bosley, Robert W., Infusion device and driving mechanism for same.
  234. Lorenzen, Eric; Gray, John; Bosley, Robert W, Infusion device and driving mechanism for same.
  235. Sheldon B. Moberg, Infusion pump for delivery of fluid.
  236. Sheldon B. Moberg ; Timothy J. Payne, Infusion pump for delivery of fluid.
  237. Das, Kusal K., Infusion pump syringe.
  238. Mern.o slashed.e Morton,DKX, Infusion pump system and an infusion pump unit.
  239. Das, Kusal K.; Shipway, Ian Maxwell, Infusion pump with a sealed drive mechanism and improved method of occlusion detection.
  240. Kusal K. Das ; Ian Maxwell Shipway, Infusion pump with a sealed drive mechanism and improved method of occlusion detection.
  241. Dextradeur, Alan J.; Konieczynski, David, Infusion pump with access regulator.
  242. McPhee Charles J. (Huntington Beach CA), Infusion pump with magnetic bag compression.
  243. William P. Van Antwerp ; Sheldon B. Moberg, Infusion site leak detection system and method of using the same.
  244. Epstein Paul (Brookline MA) Petschek Harry (Lexington MA) LaWhite Eric (South Royalton VT) Strohl Clair (Norfolk MA) Coyne Henry (Framingham MA) Kaleskas Edward (Jefferson MA) Adaniva George (Swampsc, Infusion system having plural fluid flow lines.
  245. Epstein Paul (Brookline MA) Petschek Harry (Lexington MA) LaWhite Eric (South Royalton VT) Strohl Clair (Norfolk MA) Coyne Henry (Framingham MA) Kaleskas Edward (Jefferson MA) Adaniva George (Swampsc, Infusion system having plural fluid input ports and at least one patient output port.
  246. McMullen Ray ; Kratoska Paul ; Gardner Anthony, Infusion systems with patient-controlled dosage features.
  247. Reinicke Robert H. (Mission Viego CA), Injectable infusion pump apparatus for implanting long-term dispensing module and medication in an animal and method the.
  248. Marano April A. ; Field Jeffrey F. ; Funderburk Jeffery V., Injector for a subcutaneous infusion set.
  249. Funderburk Jeffery V. ; Marano April A. ; Field Jeffrey F., Injector for a subcutaneous insertion set.
  250. Bobroff, Randa M.; Kiliszewski, Lawrence; Lickliter, Hans; Houghton, Frederick C.; Safabash, Jason H.; McConnell, Susan M.; Marano, April A., Insertion device for an insertion set and method of using the same.
  251. Safabash Jason H. ; McConnell Susan M. ; Adair Randy W. ; Funderburk Jeffery V. ; Marano April A. ; Field Jeffrey F., Insertion device for an insertion set and method of using the same.
  252. Konopka April A. (San Dimas CA), Insulin compatible infusion set.
  253. Siposs George G. (2855 Velasco La. Costa Mesa CA 92626), Insulin delivery system.
  254. Schneider Philip H. (2939A Cowley Way San Diego CA 92117) Weber William J. (520 W. Ellis Ave. Inglewood CA 90302) Massaro Thomas A. (1339 Hill Top Rd. Charlottesville VA 22903), Insulin infusion pump.
  255. Blomquist Michael L., Intermittent fluid delivery apparatus and method.
  256. Jacobs Michael W. (Surrey CAX), Intraosseous infusion device.
  257. Kamen Dean L. (Bedford NH) Faust Valentine (Bow NH), Intravenous fluid delivery system with air elimination.
  258. Larkins William T. (Manchester NH) Beavis Russell (Manchester NH) Kamen Dean L. (Bedford NH), Intravenous-line air-detection system.
  259. Manning Robert ; Larkins William T. ; Houle Philip ; Kamen Dean L. ; Faust Valentine, Intravenous-line air-elimination system.
  260. Manning Robert ; Larkins William T. ; Houle Philip ; Kamen Dean L. ; Faust Valentine, Intravenous-line air-elimination system.
  261. Sage Burton H. ; Bock Carl Randolph ; Green Philip G., Iontophoretic delivery of cell adhesion inhibitors.
  262. Flaherty, J. Christopher; Garibotto, John T., Laminated patient infusion device.
  263. Palasis, Maria; Rosenthal, Arthur, Lateral needle-less injection apparatus and method.
  264. Van Antwerp, William P.; Moberg, Sheldon B.; Talbot, Cary D., Leak detection system and method of using the same.
  265. Danby, Hal C.; Hawker, John, Linearly motile infusion pump.
  266. Nelson Timothy S. (Elk River MN), Lined infusion catheter.
  267. Bryant Robert J. (Manchester NH) Bouchard Clement D. (Pembroke NH) Kamen Dean (Bedford NH) Lanigan Richard (Concord NH) Miller Bradley D. (Londonderry NH) Spencer Geoffrey P. (Manchester NH) Vincent , Liquid pumping mechanisms for peritoneal dialysis systems employing fluid pressure.
  268. Bryant Robert J. (Manchester NH) Bouchard Clement D. (Pembroke NH) Kamen Dean (Bedford NH) Lanigan Richard (Concord NH) Miller Bradley D. (Londonderry NH) Spencer Geoffrey P. (Manchester NH) Vincent , Liquid pumping mechanisms for peritoneal dialysis systems employing fluid pressure.
  269. Abrahamson, Kent D., Load cell pressure sensor for pump cassette.
  270. Berg Harvey F. (Stacy MN), Locking mechanism for a drug delivery system.
  271. Rubsamen Reid M. (Berkeley CA) Lloyd Lester J. (Orinda CA) Johansson Eric T. (Dublin CA), Lockout device for controlled release of drug from patient-activated dispenser.
  272. Rubsamen Reid M. ; Lloyd Lester John ; Johansson Eric T., Lockout device for controlled release of drug from patient-activated dispenser.
  273. Rubsamen Reid M. (Berkeley CA) Lloyd Lester J. (Orinda CA) Johansson Eric T. (Dublin CA), Lockout device for controlled release of drug from patient-activateddispenser.
  274. Bridon Dominique P.,CAX ; L'Archeveque Benoit,CAX ; Ezrin Alan M. ; Holmes Darren L.,CAX ; Leblanc Anouk,CAX ; St. Pierre Serge,CAX, Long lasting insulinotropic peptides.
  275. Bridon, Dominique P.; L'Archeveque, Benoit; Ezrin, Alan M.; Holmes, Darren L.; Leblanc, Anouk; St. Pierre, Serge, Long lasting insulinotropic peptides.
  276. Bridon, Dominique P.; L'Archeveque, Benoit; Ezrin, Alan M.; Holmes, Darren L.; Leblanc, Anouk; St. Pierre, Serge, Long lasting synthetic glucagon like peptide {GLP-!}.
  277. Bridon, Dominique P.; L'Archeveque, Benoit; Ezrin, Alan M.; Holmes, Darren L.; Leblanc, Anouk; St. Pierre, Serge, Long lasting synthetic glucagon-like peptide (GLP-1).
  278. Walsh, Joseph C.; Heiss, Aaron M.; Noronha, Glenn; Vachon, David J.; Lane, Stephen M.; Satcher, Jr., Joe H.; Peyser, Thomas A.; Van Antwerp, William Peter; Mastrototaro, John Joseph, Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers.
  279. Wojcik, Steven E., Low profile infusion set.
  280. Sage Burton H. ; Connelly Robert I., Low-profile automatic injection device with self-emptying reservoir.
  281. Sage Burton H. ; Connelly Robert I., Low-profile automatic injection device with self-emptying reservoir.
  282. Collins, Sean; Moberg, Sheldon B.; Kimball, Dave S.; Payne, Timothy, Low-profile mounting clip for personal device.
  283. Funderburk Jeffery V. (Granada Hills CA) Jordan Matthew (Los Angeles CA) McIntyre Deborah C. (Agoura Hills CA), Mated infusion pump and syringe.
  284. Flaherty, J. Christopher; Garibotto, John T., Medical apparatus remote control and method.
  285. Neftel, Frederic, Medical device for injecting liquid.
  286. Lemelson Jerome H., Medical devices using electrosensitive gels.
  287. Lemelson Jerome H., Medical devices using electrosensitive gels.
  288. Lemelson, Jerome H., Medical devices using electrosensitive gels.
  289. Kamen Dean L. (Bedford NH) Grant Kevin L. (Dover NH) Faust Valentine (Bow NH) Lanigan Richard J. (Concord NH), Medical fluid pump.
  290. Zaias, Nardo; Gilbert, Gregory F., Medical infusion and aspiration system.
  291. Strowe Robert J. (Ramsey NJ) Edwards Floyd V. (Cedarville OH) Stern Carl M. (Lawrenceville NJ), Medical infusion device.
  292. Gibson, Scott R.; Lord, Peter C.; Lorenzen, Eric M.; McConnell, Susan M.; Gray, John F.; Bosley, Robert W., Medical infusion device with a source of controlled compliance.
  293. Karen E. Kullas ; Glen French ; Stephen Albrecht ; Joan Kinniburgh ; Augustus Felix ; Nancy Drainville ; Dean L. Kamen ; Bradley Miller ; Kevin Grant, Medical irrigation pump and system.
  294. Kullas Karen E. ; French Glen ; Kinniburgh Joan ; Felix Augustus ; Tessier Philip ; Kamen Dean L. ; Miller Bradley ; Grant Kevin, Medical irrigation pump and system.
  295. Jan Willum Nielsen DK; Bjorn Gullak Larsen DK; Orla Mathiasen DK; Marc Delzac DK; Claude Teisen-Simony DK, Medical puncturing device.
  296. Nielsen, Jan Willum; Larsen, Bjørn Gullak; Mathiasen, Orla; Delzac, Marc; Teisen-Simony, Claude, Medical puncturing device.
  297. Zumschlinge Rolf,DEX, Medical puncturing set.
  298. Rapheal John R., Medical reservoir bag and system.
  299. Sten-Olof Elver SE; Jan Skansen SE, Medical system.
  300. Kovelman Paul H., Medication cartridge for an electronic pen-type injector, infusion pump, electronic delivery device, or the like, and method of making the same.
  301. Bobby E. Rogers ; Marc S. Lieberman ; Marc C. Doyle, Medication delivery apparatus.
  302. Kleeman, Michael W.; Brengle, David R.; Lieberman, Marc S., Medication delivery pump.
  303. William Peter Van Antwerp ; Poonam S. Gulati ; Gerald E. Adomian, Medication device with protein stabilizing surface coating.
  304. Colman Fredric C. (Granada Hills CA) Lord Peter C. (Santa Clarita CA), Medication infusion device with blood glucose data input.
  305. Nason Clyde K. (Valencia CA) Livingston John H. (Los Angeles CA) Schnabel Nannette M. (Valencia CA), Medication infusion pump with flexible drive plunger.
  306. VanAntwerp William P. (Los Angeles CA) Indravudh Virote (Saugus CA), Medication infusion pump with fluoropolymer valve seat.
  307. Srisathapat Chad (Sun Valley CA) Lord Peter C. (Valencia CA), Medication infusion pump with improved liquid-vapor pressure reservoir.
  308. Srisathapat Chad (Sun Valley CA) Indravudh Virote (Saugus CA), Medication infusion pump with improved pressure reservoir.
  309. Funderburk Jeffery V. ; Bowman Leif N., Medication infusion set.
  310. Funderburk, Jeffery V.; Bowman, Leif N., Medication infusion set.
  311. Onwumere Fidelis C. (Miamisberg OH) Solomon Donald D. (Spring Valley OH), Melt processable polyurethaneurea copolymers and method for their preparation.
  312. McCusker David R. (Shingle Springs CA), Membrane dome switch with tactile feel regulator shim.
  313. Scanlon David A. (Minneapolis MN), Method and apparatus for a fluid infusion system with linearized flow rate change.
  314. Starkweather, Timothy J.; Lebel, Ronald J.; Villegas, Daniel H.; Weiss, Philip T.; Armstrong, John T.; Richert, John D., Method and apparatus for communicating between an ambulatory medical device and a control device via telemetry using randomized data.
  315. Moberg, Sheldon, Method and apparatus for detection of occlusions.
  316. Sheldon Moberg, Method and apparatus for detection of occlusions.
  317. Jhuboo Nasser (St. Etienne de St. Geoirs FRX) Rondelet Jean-Claude (St. Etienne de Crossey FRX), Method and apparatus for determining pressure and detecting occlusions in a syringe pump.
  318. Heruth Kenneth T., Method and apparatus for drug infusion.
  319. Kenneth T. Heruth, Method and apparatus for drug infusion.
  320. Mann, Alfred E., Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device.
  321. Glantz Jerald, Method and apparatus for location of a catheter tip.
  322. Glantz Jerald, Method and apparatus for location of a catheter tip.
  323. Hammarberg Bjoern (Solna SEX) Rosen Jan (Grillby SEX) Slettenmark Bruno (Jaerfaella SEX), Method and apparatus for measuring the flow resistance of a catheter in an implanted medication infusion system.
  324. Demers, Jason A.; McGill, David, Method and apparatus for non-invasive breathing assist.
  325. Abreu Marcio Marc, Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions.
  326. Abreu Marcio Marc, Method and apparatus for signal transmission and detection using a contact device.
  327. Marcio Marc Abreu, Method and apparatus for signal transmission and detection using a contact device.
  328. Cheikh Roland Cherif,FRX, Method and apparatus for the delivery of elongate solid drug compositions.
  329. Levin, Howard R.; Gelfand, Mark; Bernard, Steve, Method and apparatus for ultrafiltration utilizing a long peripheral access venous cannula for blood withdrawal.
  330. Hartlaub, Jerome T; Bourget, Duane L, Method and apparatus to control drug therapy dosages in an implantable pump.
  331. Dean L. Kamen ; Charles M. Grinnell ; Marc A. Mandro ; Dennis Gilbreath ; Kevin Grant ; Jason A. Demers ; William T. Larkins ; Robert Manning ; Richard Lanigan, Method and cassette for delivering intravenous drugs.
  332. Slettenmark Bruno (Jaerfaella SEX), Method and device for internal cleaning of an implanted infusion system.
  333. Mann Alfred E. ; Mastrototaro John J. ; Hague Clifford W., Method and kit for supplying a fluid to a subcutaneous placement site.
  334. Kamen Dean L. (Bedford NH) Seale Joseph B. (Gorham ME) Briggs Joseph (Manchester NH) Arnold Finn (Sutton MA), Method and system for measuring volume and controlling flow.
  335. Jacobsen Stephen C. ; Zentner Gaylen M., Method for automatic dosing of drugs.
  336. Natwick Vernon R. (Los Altos CA) Lawless Michael W. (Poway CA) Doll Joseph E. (Saratoga CA) Wu Chung-You C. (San Francisco CA), Method for monitoring fluid flow from a volumetric pump.
  337. Gray, Larry; Bryant, Robert, Method for regulating fluid pump pressure.
  338. Ahnell Joseph E. (Hydes MD) Perks H. Mark (Baltimore MD) Sussman Mark L. (Baltimore MD) Tice Gregory (Lutherville MD), Method for the detection of biologically active agents.
  339. Srisathapat Chad (Sun Valley CA) Indravudh Virote (Saugus CA), Method of cleaning an implanted medication infusion pump with discharge side port.
  340. Nelson Timothy S., Method of making a lined infusion catheter.
  341. Houben Richard P. M.,NLX ; Renirie Alexis C. M.,NLX ; Weijand Koen J.,NLX, Method of obtaining a measure of blood glucose.
  342. Bonutti, Peter M.; Hawkins, James S., Method of using expandable cannula.
  343. Peter M. Bonutti ; James S. Hawkins, Method of using expandable cannula.
  344. Groshong Leroy E. (6446 SW. Raab Rd. Portland OR 97221) Brawn Ronald J. (5712 SW. 52nd Portland OR 97221), Methods and apparatus for intravenous therapy and hyperalimentation.
  345. Cheikh Roland Cherif (Issy-les-Moulineaux FRX), Methods and apparatus for the delivery of solid drug compositions.
  346. Cheikh Roland Cherif,FRX, Methods and apparatus for the delivery of solid drug compositions.
  347. Fei Rui G. (Seattle WA) Heimfeld Shelly (Woodinville WA) Minshall Billy W. (Mill Creek WA) Berenson Ronald J. (Mercer Island WA), Methods and device for culturing human hematopoietic cells and their precursors.
  348. Chick William L. ; Wolf David E. ; Cardullo Richard A., Methods and device for detecting and quantifying substances in body fluids.
  349. Quay, Steven C., Methods and devices for collecting, handling and processing mammary fluid samples for evaluating breast diseases, including cancer.
  350. Quay Steven C. ; Quay Debra L., Methods and devices for obtaining and assaying mammary fluid samples for evaluating breast diseases, including cancer.
  351. Constantz, Brent R., Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue.
  352. Brent R. Constantz, Methods and devices for reducing the mineral content of vascular calcified lesions.
  353. Constantz, Brent R., Methods and devices for reducing the mineral content of vascular calcified lesions.
  354. Herman, Heath H.; Herman, Tod M.; Andrews, Sr., Arlan K., Methods and devices for remediation and fermentation.
  355. Herman, Heath H.; Herman, Tod M.; Cuneo, Robert A.; Osborne, Gerard W., Methods and devices for remediation and fermentation.
  356. Van Antwerp William P. ; Van Antwerp Nannette, Methods and devices for the delivery of monomeric proteins.
  357. Bryant Robert J. ; Gray Lawrence B. ; Spencer Geoff P., Methods and systems for detecting the presence of a gas in a pump and preventing a gas from being pumped from a pump.
  358. Bryant, Robert J.; Gray, Lawrence B.; Spencer, Geoff P., Methods and systems for pulsed delivery of fluids from a pump.
  359. Bryant, Robert J.; Gray, Lawrence B.; Spencer, Geoff P., Methods for controlling a pump's flow rate by pulsed discharge.
  360. Kim, Seonyoung; Van Antwerp, William P.; Gross, Todd M.; Gulati, Poonam S., Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom.
  361. Ferber, Sarah, Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues.
  362. Wands, Jack R.; Carlson, Rolf I.; Maggio, Paul, Methods of inhibiting metastases.
  363. Tang Peng C. (Moraga CA) McMahon Gerald (Kenwood CA), Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and deri.
  364. Tang Peng C. (Moraga CA) McMahon Gerald (Kenwood CA), Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and deri.
  365. Tarara, Thomas E.; Weers, Jeffry G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Methods of spray drying pharmaceutical compositions.
  366. Vanessa Hsei ; Iphigenia Koumenis ; Steven Leong ; Leonard Presta ; Zahra Shahrokh ; Gerardo Zapata, Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates.
  367. Vanessa Hsei ; Iphigenia Koumenis ; Steven Leong ; Leonard Presta ; Zahra Shahrokh ; Gerardo Zapata, Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates.
  368. Sheldon B. Moberg ; James D. Causey, III ; Rex O. Bare ; Andrew J. Scherer ; Bradley J. Sargent, Methods, apparatuses, and uses for infusion pump fluid pressure and force detection.
  369. Douglas, Joel; Hugo, Jr., Robert, Micro infusion drug delivery device.
  370. Connelly, Robert I.; Pettis, Ronald J., Microdevice and method of delivering or withdrawing a substance through the skin of an animal.
  371. Prausnitz, Mark R.; Allen, Mark G.; McAllister, Devin V.; Henry, Sebastien, Microneedle device for transport of molecules across tissue.
  372. Mark G. Allen ; Mark R. Prausnitz ; Devin V. McAllister ; Florent Paul Marcel Cros, Microneedle devices and methods of manufacture and use thereof.
  373. Eppstein Jonathan A. ; Hatch Michael R. ; Yang Difei, Microporation of human skin for drug delivery and monitoring applications.
  374. Eppstein, Jonathan A., Microporation of tissue for delivery of bioactive agents.
  375. Lebel, Ronald J.; Shahmirian, Varaz; Bowman, IV, Sam W.; Starkweather, Timothy J.; Morgan, Wayne A., Microprocessor controlled ambulatory medical apparatus with hand held communication device.
  376. Lebel, Ronald J.; Shahmirian, Varaz; Bowman, IV, Sam W.; Starkweather, Timothy J.; Morgan, Wayne A., Microprocessor controlled ambulatory medical apparatus with hand held communication device.
  377. Lebel, Ronald J.; Shahmirian, Varaz; Bowman, IV, Sam W.; Starkweather, Timothy J.; Villegas, Daniel H.; Choy, David Y.; Weiss, Philip T., Microprocessor controlled ambulatory medical apparatus with hand held communication device.
  378. Lebel, Ronald J.; Shahmirian, Varaz; Starkweather, Timothy J.; Villegas, Daniel H.; Weiss, Philip T., Microprocessor controlled ambulatory medical apparatus with hand held communication device.
  379. Van Antwerp, William Peter; Gulati, Poonam S., Mixed buffer system for stabilizing polypeptide formulations.
  380. Flaherty, J. Christopher, Modular infusion device and method.
  381. Field Jeffrey F. (North Hills CA) Savage Heather M. (Ventura CA), Mounting clip for a medication infusion pump.
  382. Sims Nathaniel M. ; Wollowitz Michael H. ; Wrightson David M., Multi-dose syringe driver.
  383. Sims Nathaniel M. ; Wollowitz Michael H. ; Wrightson David M., Multi-dose syringe driver.
  384. Eppstein Jonathan A., Multiple mechanical microporation of skin or mucosa.
  385. Johnson Steven W. ; Davis Bryan G., Multiple sheath catheter using multiple stages and method of use.
  386. Kaelin, Jr., William G.; Ivan, Mircea, Muteins of hypoxia inducible factor alpha and methods of use thereof.
  387. Joseph Gross IL; Haim Danon IL, Needle and method for delivery of fluids.
  388. Gross Joseph,ILX ; Danon Haim,ILX, Needle for subcutaneous delivery of fluids.
  389. Jason H. Safabash, Needle safe transfer guard.
  390. Safabash Jason Hossein, Needle safe transfer guard.
  391. Safabash, Jason H., Needle safe transfer guard.
  392. Weston Terence Edward,GBX, Needle-less injector.
  393. Dy Norman ; Van Antwerp William P., Negative pressure pump.
  394. Kollias, Nikiforos; Tian, Wei Dong; Freeman, Jenny E., Non-invasive tissue glucose level monitoring.
  395. Kollias, Nikiforos; Tian, Wei Dong; Freeman, Jenny E., Non-invasive tissue glucose level monitoring.
  396. Trepagnier, Pierre; Freeman, Jenny; Mansfield, James; Brand, Derek; Hopmeier, Michael J.; Kollias, Nikiforos, Non-invasive tissue glucose level monitoring.
  397. Abreu, Marcio Marc, Noninvasive measurement of chemical substances.
  398. Olsen James M., Occlusion detection system for an infusion pump.
  399. Olsen James M. (Plymouth MN), Occlusion detection system for an infusion pump.
  400. Olsen James M. (Plymouth MN), Optical reflection systems and methods for cassette identification fordrug pumps.
  401. Olsen James M., Overfill protection systems for implantable drug delivery devices.
  402. Stocker, Penny J.; Steimel-Crespi, Dorothy T.; Crespi, Charles L., P-glycoproteins and uses thereof.
  403. Stocker, Penny J.; Steimel-Crespi, Dorothy T.; Crespi, Charles L.; Reif, Timothy C.; Patten, Christopher J., P-glycoproteins and uses thereof.
  404. Alchas Paul G. (Montclair NJ), Parenteral fluid administration set.
  405. Alchas Paul G. (Montclair NJ), Parenteral fluid administration set.
  406. Idriss Samir F. (Hyde Park MA) Makower Joshua (Nanuet NY), Passive shuttle metering device for implantable drug delivery system.
  407. O'Neil Alexander George Brian,AUX, Patient controllable drug delivery system flow regulating means.
  408. Young Joe W. (Laguna Hills CA), Patient controlled analgesia conversion.
  409. Kriesel Marshall S. ; Kazemzadeh Farhad ; Feng William W. ; Thompson Thomas N., Patient controlled fluid delivery device.
  410. Gorton Lanny A. (Sunland CA), Patient-controlled analgesia security attachment for a medication infusion system.
  411. Neftel Frederic (Paris FRX) Bouvier Bernard (Eragny-Sur-Oise FRX), Peristaltic pump cassette.
  412. Neftel Frederic,CHX ; Bouvier Bernard,FRX, Peristaltic pump device having an insert cassette of reduced complexity.
  413. Kamen Dean (Bedford OH) Spencer Geoffrey P. (Manchester NH), Peritoneal dialysis methods that emulate gravity flow.
  414. Kamen Dean (Bedford NH) Lanigan Richard (Concord NH) Vincent Douglas E. (Manchester NH), Peritoneal dialysis systems and methods employing a liquid distribution and pump cassette with self-contained air isolat.
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  427. Van Antwerp, William P., Polymer compositions containing bioactive agents and methods for their use.
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  429. Van Antwerp William P., Polyurethane/polyurea compositions containing silicone for biosensor membranes.
  430. Edge, Albert; Gunsalus, J. Ryan; Afdhal, Nezam H., Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function.
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  438. Johnson Jay G. (Maple Plain MN), Pressure plate for pump and reservoir enclosure.
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  445. Luther Ronald B. ; Overton Richard A. ; Dickerson Charles W. ; Keith Lane ; Roth Ron ; Nichols Bruce, Process of making a catheter.
  446. Livingston John H. (Los Angeles CA) Frye Ward K. (San Luis Obispo CA) Field Jeffrey F. (Northridge CA), Proctective case for a medication infusion pump.
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  463. Arison Byron H. ; Baillie Thomas A. ; Balani Suresh K. ; Dufresne Claude,CAX, Quinoline leukotriene antagonists.
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  474. Johnson Jay Gregory, Reusable cassette housings and methods.
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  484. Van Antwerp William Peter, Silicon-containing biocompatible membranes.
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  520. Houben Richard P. M.,NLX ; Renirie Alexis C. M.,NLX ; Weijand Koen J.,NLX, System for pancreatic stimulation and glucose measurement.
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  533. Tran Loi H. (Wheaton IL), Therapeutic agent delivery system and method.
  534. Veech Richard L., Therapeutic compositions.
  535. Veech Richard L., Therapeutic compositions.
  536. Veech Richard Lewis, Therapeutic compositions.
  537. Marsh ; Jr. Henry C. ; Smith Richard A.G.,GBX ; Yeh Chang-Jing Grace ; Lifter John ; Freeman Anne Mary,GBX ; Gosselin Michael L., Therapeutic methods employing sialylated glycoforms of soluble complement receptor 1 (SCR 1).
  538. Streeter James M. (Highland UT), Thermoelectric chiller and automatic syringe.
  539. Streeter, James M., Thermoelectric chiller and automatic syringe.
  540. Flaherty, J. Christopher; Garibotto, John T., Transcutaneous delivery means.
  541. Thorn, Richard M.; Lanser, Marc E.; Moses, Marsha A.; Wiederschain, Dmitri G., Troponin subunit I fragment and homologs thereof.
  542. Devine Terrence M., Ultrasonic needle for surgical emulsification.
  543. Dennis A. Briggs, Uninterrupted flow pump apparatus and method.
  544. Deckert Clinton L. ; Maerzke James T. ; Brown Jeffrey P., Unitary molded elastomer conduit for use with a medical infusion pump.
  545. Filvaroff, Ellen H.; Okumu, Franklin W., Use of insulin for the treatment of cartilagenous disorders.
  546. Bryant Robert J. (Manchester NH) Finkelstein Jeffrey (Shelburne VT) Kamen Dean (Bedford NH) Lanigan Richard (Concord NH) Miller Bradley D. (Londonderry NH) Spencer Geoffrey P. (Manchester NH), User interface and monitoring functions for automated peritoneal dialysis systems.
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  551. Kamen Dean L. (Bedford NH), Valve system with removable fluid interface.
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  14. Gonnelli, Robert R.; McAllister, Devin V.; Levesque, Steven F., Hydraulically actuated pump for fluid administration.
  15. Gonnelli, Robert R.; McAllister, Devin V.; Levesque, Steven F., Hydraulically actuated pump for fluid administration.
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  23. Burnett, Daniel R.; Hermanson, Christopher; Ahlman, James H.; Strul, Bruno, Method and apparatus for electrical stimulation therapy.
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  29. Gonnelli, Robert R., Methods and devices for delivering GLP-1 and uses thereof.
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  34. Burnett, Daniel R., Methods and devices for performing electrical stimulation to treat various conditions.
  35. Burnett, Daniel R., Methods and devices for performing electrical stimulation to treat various conditions.
  36. Hegde, Anant V.; Rajguru, Amit; Burnett, Daniel Rogers; Hermanson, Christopher, Microneedle electrode.
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  42. Metzmaker, Thomas; Saint, Sean; Michaud, Michael; Rosinko, Michael J.; Swanson, Vance, Pump device with multiple medicament reservoirs.
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  46. Rosinko, Michael J.; Kruse, Geoffrey A.; Harris, Paul, System and method for detecting occlusions in an infusion pump.
  47. Metzmaker, Thomas; Saint, Sean; Michaud, Michael; Rosinko, Michael J.; Swanson, Vance, Systems including vial adapter for fluid transfer.
  48. DiPerna, Paul M., Two chamber pumps and related methods.
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