최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | UP-0831354 (2004-04-23) |
등록번호 | US-7530968 (2009-07-01) |
발명자 / 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 48 인용 특허 : 565 |
Presently disclosed is a hydraulic pump device and use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or
Presently disclosed is a hydraulic pump device and use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may thence flow through any suitable infusion set into a patient removeably attached thereto.
I claim: 1. A hydraulically actuated fluid delivery system for delivery of a liquid medicament, comprising: (a) a fluid storage chamber for storing said liquid medicament, said fluid storage chamber having an output orifice through which said liquid medicament can be expelled; (b) a single expandab
I claim: 1. A hydraulically actuated fluid delivery system for delivery of a liquid medicament, comprising: (a) a fluid storage chamber for storing said liquid medicament, said fluid storage chamber having an output orifice through which said liquid medicament can be expelled; (b) a single expandable pump chamber functionally connected to said fluid storage chamber by a moveable barrier, wherein the rate of movement of said moveable barrier caused by expansion of said pump chamber is adjustable to produce variable dosing under patient control; (c) a hydraulic fluid reservoir functionally connected to a first actuator and having a high viscosity fluid stored therein, said hydraulic fluid reservoir fluidly connected to said pump chamber by a fixed aperture; (d) a second actuator which physically acts on said pump chamber, wherein said second actuator is controlled independently of said first actuator; and (e) a needle functionally connected to the output orifice for delivery of liquid medicament expelled from said fluid storage chamber to an individual, wherein said pump chamber continuously expands upon actuation of said system with said first actuator; wherein operating said first actuator causes said high viscosity fluid to flow into said pump chamber through said fixed aperture at a constant rate, thereby displacing said moveable barrier to compress said fluid storage chamber and causing a quantity of said liquid medicament to be expelled through said orifice; wherein operating said second actuator independently causes displacement of said moveable barrier to compress said fluid storage chamber, thereby causing a quantity of said liquid medicament to be expelled; and wherein concurrently operating both of said first and second actuators causes displacement of the moveable barrier to compress said fluid storage chamber at an increased rate relative to operating either actuator alone. 2. The fluid delivery system of claim 1 wherein said pump chamber and said fluid storage chamber are both within a compartment. 3. The fluid delivery system of claim 1 wherein said moveable barrier is a piston or plunger plate. 4. The fluid delivery system of claim 1 wherein said moveable barrier is one or more deformable membranes separating said pump and fluid storage chambers. 5. The fluid delivery system of claim 1 wherein the wall of said fluid storage chamber is composed of bio-inert materials. 6. The fluid delivery system of claim 1 wherein said quantity of said liquid medicament is expelled at a rate selected from: about 100 nl-1 μl per minute, about 1-10 μl per minute, about 10-100 μl per minute, and about 100 μl-100 milliters per hour. 7. The fluid delivery system of claim 1 wherein said first actuator comprises a miniaturized bellows crank, paired rollers, one or more piezoelectric elements, a ratchet or stepper motor driven unit, a two-plate hinged peristaltic mechanism, an electrically driven or piezoelectric mechanism. 8. The fluid delivery system of claim 1 wherein said second actuator comprises a miniaturized bellows crank, paired rollers, one or more piezoelectric elements, a ratchet or stepper motor driven unit, a two-plate hinged peristaltic mechanism, an electrically driven or piezoelectric mechanism. 9. The fluid delivery system of claim 1 wherein said first actuator employs one or more springs. 10. The fluid delivery system of claim 1 wherein said second actuator employs one or more springs. 11. The fluid delivery system of claim 1 wherein said medicament is insulin, an opiate, a hormone, or a psychotropic therapeutic composition. 12. The fluid delivery system of claim 1 wherein said system is latex-free and is suitable for use in a latex-intolerant patient. 13. The fluid delivery system of claim 1 wherein said system is capable of delivering said liquid medicament over a period of more than 5 hours, more than 24 hours, more than 3 days, or more than one week. 14. The fluid delivery system of claim 1 further comprising a connective passage linking said first hydraulic fluid reservoir to said pump chamber through said aperture. 15. The fluid delivery system of claim 1 wherein the viscosity of said high viscosity fluid is about ISO VG 1500 or more. 16. The fluid delivery system of claim 1 wherein said first actuator causes constant delivery of said liquid medicament, and said second actuator causes a bolus delivery of said liquid medicament under patient control. 17. The fluid delivery system of claim 1 wherein said first actuator generates a force of from about 0.001 lbs to about 10 lbs. 18. A hydraulically actuated pump system comprising: (a) a single expandable pump chamber functionally connected to a moveable barrier, wherein the rate of movement of said moveable barrier caused by expansion of said pump chamber is adjustable to produce variable dosing under patient control; (b) a hydraulic fluid reservoir functionally connected to a first actuator and having a high viscosity fluid stored therein, said hydraulic fluid reservoir fluidly connected to said pump chamber by a fixed aperture; and (c) a second actuator which physically acts on said pump chamber, wherein said second actuator is controlled independently of said first actuator, wherein said pump chamber continuously expands upon actuation of said pump with said first actuator; wherein operating said first actuator causes said high viscosity fluid to flow into said pump chamber through said fixed aperture at a constant rate, thereby displacing said moveable barrier; wherein operating said second actuator independently causes displacement of said moveable barrier; and wherein concurrently operating both of said first and second actuators causes displacement of the moveable barrier at an increased rate relative to operating either actuator alone. 19. The pump system of claim 18 wherein said moveable barrier is a piston or plunger plate. 20. The pump system of claim 18 wherein said moveable barrier is one or more deformable membranes. 21. The pump system of claim 18 wherein said first actuator comprises a miniaturized bellows crank, paired rollers, one or more piezoelectric elements, a ratchet or stepper motor driven unit, a two-plate hinged peristaltic mechanism, an electrically driven or piezoelectric mechanism. 22. The pump system of claim 18 wherein said second actuator comprises a miniaturized bellows crank, paired rollers, one or more piezoelectric elements, a ratchet or stepper motor driven unit, a two-plate hinged peristaltic mechanism, an electrically driven or piezoelectric mechanism. 23. The pump system of claim 18 wherein said first actuator employs one or more springs. 24. The pump system of claim 18 wherein said system is latex-free and is suitable for use in a latex-intolerant patient. 25. The pump system of claim 18 further comprising a connective passage linking said first hydraulic fluid reservoir to said pump chamber through said aperture. 26. The pump system of claim 18 wherein the viscosity of said high viscosity fluid is about ISO VG 1500 or more. 27. The pump system of claim 18 wherein said first actuator generates a force of from about 0.001 lbs to about 10 lbs. 28. A hydraulically actuated fluid delivery system for delivery of a liquid medicament, comprising: (a) a single fluid storage chamber for storing said liquid medicament, said fluid storage chamber having an output orifice through which said liquid medicament can be expelled; (b) a single expandable pump chamber functionally connected to said fluid storage chamber by a moveable barrier, wherein the rate of movement of said moveable barrier caused by expansion of said pump chamber is adjustable to produce variable dosing under patient control; (c) a hydraulic fluid reservoir functionally connected to a first actuator employing one or more springs, said hydraulic fluid reservoir having a high viscosity fluid stored therein, and said hydraulic fluid reservoir fluidly connected to said pump chamber by a connective passage terminating in a fixed aperture; (d) a second actuator which physically acts on said pump chamber, wherein said second actuator is controlled independently of said first actuator; (e) a needle functionally connected to the output orifice for delivery of liquid medicament expelled from said fluid storage chamber to an individual; and (f) an adhesive means for affixing said delivery system to the skin of a patient, wherein said pump chamber continuously expands upon actuation of said system with said first actuator; wherein operating said first actuator causes said high viscosity fluid to flow into said pump chamber through said fixed aperture at a constant rate, thereby displacing said moveable barrier to compress said fluid storage chamber and causing a quantity of said liquid medicament to be expelled through said orifice; wherein operating said second actuator independently causes displacement of said moveable barrier to compress said fluid storage chamber, thereby causing a quantity of said liquid medicament to be expelled; wherein concurrently operating both of said first and second actuators causes displacement of the moveable barrier to compress said fluid storage chamber at an increased rate relative to operating either actuator alone; and wherein operating said first actuator causes constant delivery of said liquid medicament and operating said second actuator cause a bolus delivery of said liquid medicament under patient control. 29. The fluid delivery system of claim 28 wherein said moveable barrier is a piston or plunger plate. 30. The fluid delivery system of claim 28 wherein said moveable barrier is one or more deformable membranes separating said pump and fluid storage chambers. 31. The fluid delivery system of claim 28 wherein the wall of said fluid storage chamber is composed of bio-inert materials. 32. The fluid delivery system of claim 28 wherein said quantity of said liquid medicament is expelled at a rate selected from: about 100 nl-1 μl per minute, about 1-10 μl per minute, about 10-100 μl per minute, and about 100 μl-100 milliters per hour. 33. The fluid delivery system of claim 28 wherein said system is latex-free and is suitable for use in a latex-intolerant patient. 34. The fluid delivery system of claim 28 wherein said system is capable of delivering said liquid medicament over a period of more than 5 hours, more than 24 hours, more than 3 days, or more than one week. 35. The fluid delivery system of claim 28 wherein the viscosity of said high viscosity fluid is about ISO VG 1500 or more. 36. The fluid delivery system of claim 28 wherein said first actuator generates a force of from about 0.001 lbs to about 10 lbs.
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