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Targeted and high density drug loaded polymeric materials

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/14
  • C07K-014/00
  • C07H-021/00
출원번호 UP-0170817 (2005-06-30)
등록번호 US-7534449 (2009-07-01)
발명자 / 주소
  • Saltzman, William Mark
  • Fahmy, Tarek
  • Fong, Peter
출원인 / 주소
  • Yale University
대리인 / 주소
    Pabst Patent Group LLP
인용정보 피인용 횟수 : 65  인용 특허 : 7

초록

Polymeric delivery devices have been developed which combine high loading/high density of molecules to be delivered with the option of targeting. As used herein, "high density" refers to microparticles having a high density of ligands or coupling agents, which is in the range of 1000-10,000,000, mor

대표청구항

We claim: 1. Polymeric microparticles or nanoparticles for delivery of a therapeutic, nutritional, diagnostic or prophylactic agent incorporated in a high density on or within the microparticles, the microparticles or nanoparticles comprising targeting ligands present in a density of between about

이 특허에 인용된 특허 (7)

  1. Klemm Klaus (Darmstadt DEX) Wahlig Helmut (Darmstadt DEX), Antibacterial wound dressing.
  2. Grandfils Christian,BEX ; Jerome Robert,BEX ; Nihant Nicole,BEX ; Teyssie Philippe,BEX, Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery.
  3. Sankaram, Mantripragada, Biodegradable compositions for the controlled release of encapsulated substances.
  4. Gref Ruxandra (Nancy FRX) Minamitake Yoshiharu (Brookline MA) Langer Robert S. (Newton MA), Biodegradable injectable nanoparticles.
  5. Haynes Duncan H. ; Bodeker Ben H. ; Kline Mark D., Drug releasing surgical implant or dressing material.
  6. Lanza, Gregory M.; Wickline, Samuel A., Ligand-targeted emulsions carrying bioactive agents.
  7. Giachelli, Cecilia M.; Steitz, Susie, Methods of inhibiting ectopic calcification.

이 특허를 인용한 특허 (65)

  1. Ducharme, Richard W.; Sugg, David E., Apparatus and methods for containing and delivering therapeutic agents.
  2. Ducharme, Richard W., Apparatus and methods for delivering therapeutic agents.
  3. Andreas, Bernard; French, Ronald; Deem, Mark E.; Gifford, III, Hanson S.; Will, Allan, Apparatus and methods for delivery of braided prostheses.
  4. Acosta, Pablo; Andreas, Bernard; Landreville, Steve; Snow, David W., Apparatus and methods for delivery of multiple distributed stents.
  5. Acosta, Pablo; Andreas, Bernard; Landreville, Steve; Snow, David W., Apparatus and methods for delivery of multiple distributed stents.
  6. Chew, Sunmi; Andreas, Bernard; Gifford, III, Hanson S.; French, Ron; Deem, Mark E.; Will, Allan, Apparatus and methods for delivery of multiple distributed stents.
  7. Andreas, Bernard; Chew, Sunmi; Dittmer, Jeremy; Grainger, Jeff; Kao, Stephen; Lowe, David; Mao, Bryan; Olson, Stephen; Snow, David; Welk, Craig, Apparatus and methods for deployment of linked prosthetic segments.
  8. Andreas, Bernard; Chew, Sunmi; Dittmer, Jeremy; Grainger, Jeff; Kao, Stephen; Lowe, David; Mao, Bryan; Olson, Steve; Snow, David; Welk, Craig, Apparatus and methods for deployment of linked prosthetic segments.
  9. Will, Allan; Andreas, Bernard; Chew, Sunmi, Apparatus and methods for deployment of vascular prostheses.
  10. Lowe, David; Bonsignore, Craig; Snow, David W.; Robinson, Timothy; Wiesman, Joshua P.; Henderson, Dawn; Maier, Nathan, Apparatus having variable strut length and methods of use.
  11. Heller, Phillip F., Coacervate microparticles useful for the sustained release administration of therapeutic agents.
  12. Castillo, Gerardo M.; Bolotin, Elijah, Composition for long-acting peptide analogs.
  13. Castillo, Gerardo M.; Bolotin, Elijah M., Composition for long-acting peptide analogs.
  14. Castillo, Gerardo M.; Bolotin, Elijah M., Composition for long-acting peptide analogs.
  15. Popov, Alexey; Enlow, Elizabeth M.; Chen, Hongming; Bourassa, James, Compositions and methods for ophthalmic and/or other applications.
  16. Bolotin, Elijah M.; Castillo, Gerardo M., Compositions for delivery of therapeutics and other materials.
  17. Bolotin, Elijah M.; Castillo, Gerardo M., Compositions for delivery of therapeutics and other materials.
  18. Bolotin, Elijah M.; Castillo, Gerardo M., Compositions for delivery of therapeutics and other materials.
  19. Bolotin, Elijah M., Compositions for delivery of therapeutics and other materials, and methods of making and using the same.
  20. Enlow, Elizabeth; Nguyen, Minh Ngoc; Ong, Winston Z., Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof.
  21. Enlow, Elizabeth; Nguyen, Minh Ngoc; Ong, Winston Z., Crystalline forms of therapeutic compounds and uses thereof.
  22. Enlow, Elizabeth; Nguyen, Minh Ngoc; Ong, Winston Z., Crystalline forms of therapeutic compounds and uses thereof.
  23. Enlow, Elizabeth; Nguyen, Minh Ngoc; Ong, Winston Zapanta, Crystalline forms of therapeutic compounds and uses thereof.
  24. Nguyen, Minh Ngoc; Ong, Winston Zapanta, Crystalline forms of therapeutic compounds and uses thereof.
  25. George, Robert; Snow, David W.; Carrison, Harold F.; Acosta, Pablo, Custom length stent apparatus.
  26. Andreas, Bernard; Karratt, Joseph; Flom, James R.; Blackwood, Bradley, Devices and methods for controlling and indicating the length of an interventional element.
  27. Andreas, Bernard; Karratt, Joseph; Flom, James R.; Blackwood, Bradley, Devices and methods for controlling and indicating the length of an interventional element.
  28. Snow, David W.; Demarais, Denise; Lin, Stuart, Devices and methods for controlling expandable prostheses during deployment.
  29. Snow, David W.; Demarais, Denise; Lin, Stuart, Devices and methods for controlling expandable prostheses during deployment.
  30. Snow, David W.; Karratt, Joseph; Grainger, Jeffry J.; Demarais, Denise, Devices and methods for controlling expandable prostheses during deployment.
  31. Snow, David W.; Robinson, Timothy W.; Davila, Dawn M.; Lin, Stuart, Devices and methods for controlling expandable prostheses during deployment.
  32. Snow, David W.; Robinson, Timothy W.; Henderson, Dawn M.; Lin, Stuart, Devices and methods for controlling expandable prostheses during deployment.
  33. Hanes, Justin; Dawson, Michelle Rose; Wirtz, Denis; Fu, Jie; Krauland, Eric Mark, Drugs and gene carrier particles that rapidly move through mucous barriers.
  34. Andersen, Erik; Wen, Ning, Expandable stent.
  35. Castillo, Gerardo M.; Bolotin, Elijah M., Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same.
  36. Krieg, Arthur M.; Klinman, Dennis; Steinberg, Alfred D., Immunostimulatory nucleic acid molecules.
  37. Lee, Jeoung Soo, Multi-functional particles and methods of using the same.
  38. Popov, Alexey; Enlow, Elizabeth M.; Bourassa, James; Gardner, Colin R.; Chen, Hongming; Ensign, Laura M.; Lai, Samuel K.; Yu, Tao; Hanes, Justin; Yang, Ming, Nanocrystals, compositions, and methods that aid particle transport in mucus.
  39. Popov, Alexey; Enlow, Elizabeth M.; Bourassa, James; Gardner, Colin R.; Chen, Hongming; Ensign, Laura M.; Lai, Samuel K.; Yu, Tao; Hanes, Justin; Yang, Ming, Nanocrystals, compositions, and methods that aid particle transport in mucus.
  40. Popov, Alexey; Enlow, Elizabeth M.; Bourassa, James; Gardner, Colin R.; Chen, Hongming; Ensign, Laura M.; Lai, Samuel K.; Yu, Tao; Hanes, Justin; Yang, Ming, Nanocrystals, compositions, and methods that aid particle transport in mucus.
  41. Popov, Alexey; Enlow, Elizabeth; Bourassa, James; Gardner, Colin R; Chen, Hongming; Ensign, Laura M; Lai, Samuel K; Yu, Tao; Hanes, Justin; Yang, Ming, Nanocrystals, compositions, and methods that aid particle transport in mucus.
  42. Popov, Alexey; Enlow, Elizabeth; Bourassa, James; Gardner, Colin R; Chen, Hongming; Ensign, Laura M; Lai, Samuel K; Yu, Tao; Hanes, Justin; Yang, Ming, Nanocrystals, compositions, and methods that aid particle transport in mucus.
  43. Sosin, Howard B.; Caplan, Michael J., Nanoparticle compositions.
  44. Sosin, Howard; Caplan, Michael; Fahmy, Tarek, Nanoparticle compositions.
  45. Sung, Hsing-Wen; Chen, Mei-Chin; Tu, Hosheng, Nanoparticles for targeting hepatoma cells and delivery means.
  46. Caplan, Michael J., Nanoparticles for treatment of allergy.
  47. Castillo, Gerardo M.; Bolotin, Elijah M.; Bogdanov, Jr., Alexei A., Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same.
  48. Decuzzi, Paolo; Ferrari, Mauro, Particles for cell targeting.
  49. Andreas, Bernard; Grainger, Jeffry J., Rapid exchange interventional devices and methods.
  50. Castillo, Gerardo M.; Bolotin, Elijah, Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same.
  51. Castillo, Gerardo M.; Bolotin, Elijah M., Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same.
  52. Andreas, Bernard, Stent delivery apparatus and method.
  53. Ducharme, Richard W, Systems and methods for delivering therapeutic agents.
  54. Ducharme, Richard W.; Sugg, David E.; Skelton, Eugene E.; Bruggemann, Martin; Bryce, Lyndsey, Systems and methods for delivering therapeutic agents.
  55. Ducharme, Richard W.; Sugg, David E.; Skelton, Eugene; Bruggemann, Martin; Bryce, Lyndsey, Systems and methods for delivering therapeutic agents.
  56. Ducharme, Richard W.; Sugg, David E.; Skelton, Eugene; Bruggemann, Martin; Bryce, Lyndsey, Systems and methods for delivering therapeutic agents.
  57. Gittard, Shaun D., Therapeutic agents for delivery using a catheter and pressure source.
  58. Ong, Winston Zapanta; Nowak, Pawel Wojciech; Askew, Ben C.; Kim, Jinsoo, Therapeutic compounds and uses thereof.
  59. Ong, Winston Zapanta; Nowak, Pawel Wojciech; Askew, Ben C.; Kim, Jinsoo, Therapeutic compounds and uses thereof.
  60. Ong, Winston Zapanta; Nowak, Pawel Wojciech; Askew, Ben C.; Kim, Jinsoo, Therapeutic compounds and uses thereof.
  61. Ong, Winston Zapanta; Nowak, Pawel Wojciech; Askew, Ben C.; Kim, Jinsoo, Therapeutic compounds and uses thereof.
  62. Ong, Winston Zapanta; Nowak, Pawel Wojciech; Askew, Ben C.; Kim, Jinsoo, Therapeutic compounds and uses thereof.
  63. Ong, Winston Zapanta; Nowak, Pawel Wojciech; Askew, Ben C.; Kim, Jinsoo, Therapeutic compounds and uses thereof.
  64. Ruane, Patrick H.; Wilson, Cameron L., Thermo-mechanically controlled implants and methods of use.
  65. Ruane, Patrick H.; Wilson, Cameron L., Thermo-mechanically controlled implants and methods of use.
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