A lubricious composition suitable for use on medical device, the composition including at least one alkoxylated acrylate compound having at least two acrylate groups per molecule and at least one second component which provides lubricity.
대표청구항▼
The invention claimed is: 1. A lubricious composition suitable for use on medical device comprising at least one polymerizable alkoxylated (meth)acrylate compound having at least two acrylate groups per molecule of the compound and a water solubility of about 15% or greater, said polymerizable alko
The invention claimed is: 1. A lubricious composition suitable for use on medical device comprising at least one polymerizable alkoxylated (meth)acrylate compound having at least two acrylate groups per molecule of the compound and a water solubility of about 15% or greater, said polymerizable alkoxylated (meth)acrylate is a member selected from the group consisting of alkoxylated trimethylol alkane tri(meth)acrylates, alkoxylated neopentyl glycol di(meth)acrylates, alkoxylated pentaerythritol tetra(meth)acrylates, trimethylolpropane ethoxylate (1 EO/OH) methyl ether di(meth)acrylate, aromatic alkoxylated (meth) acrylates having a water solubility of about 15% or greater, and mixtures thereof, and at least one second component which provides lubricity when wet. 2. The lubricious composition of claim 1 wherein said at least one polymerizable. alkoxylated (meth)acrylate compound has a water solubility of about 50% or greater. 3. The lubricious composition of claim 1 wherein said at least one polymerizable alkoxylated (meth)acrylate compound is a monomer. 4. The lubricious composition of claim 1 wherein said at least one polymerizable alkoxylated (meth)acrylate compound has a molecular weight of about 1000 g/mole or less. 5. The lubricious composition of claim 1 wherein said at least one polymerizable alkoxylated (meth)acrylate compound has at least three (meth)acrylate groups per molecule. 6. The lubricious composition of claim 1 wherein said at least one polymerizable alkoxylated (meth)acrylate compound has about 1 to about 20 moles alkoxylate. 7. The lubricious composition of claim 1 wherein said at least one polymerizable alkoxylated (meth)acrylate compound has about 2 to about 18 moles alkoxylate. 8. The lubricious composition of claim 1 wherein said at least one polymerizable alkoxylated (meth)acrylate compound has 3 to about 15 moles alkoxylate. 9. The lubricious composition of claim 1 wherein said at least one polymerizable alkoxylated (meth)acrylate compound is a non-aromatic alkoxylated (meth)acrylate compound. 10. The lubricious composition of claim 1 wherein said at least one polymerizable alkoxylated (meth)acrylate compound is an alkoxylated trimethylol propane triacrylate. 11. The lubricious composition of claim 1 wherein said alkoxylated trimethylol propane triacrylate is an ethoxylated trimethylol propane triacrylate. 12. The lubricious composition of claim 1 further comprising at least one photoinitiator. 13. The lubricious composition of claim 12 wherein said at least one photoinitiator is a member selected from the group consisting of benzophenones, aromatic-aliphatic ketones, α-amino ketones, benzil ketals, derivatives thereof, and mixtures thereof. 14. The lubricious composition of claim 13 wherein said at least one photoinitiator is 2, 2-dimethoxy-2-phenyl acetophenone. 15. The lubricious composition of claim 13 wherein said at least one photoinitiator is 2-methyl1-[4-methylthio)phenyl]2-morpholinopropan-1-one, 2-benzyl-2-(dimethylamine)-1-[4morpholinyl)phenyl]-1-butanone or mixture thereof. 16. The lubricious composition of claim 13 further comprising an acrylated amine synergist. 17. The lubricious composition of claim 1 wherein said at least one second component is hydrophilic. 18. The lubricious composition of claim 1 wherein said at least one second component is selected from the group consisting of polyalkylene glycols, alkoxy polyalkylene glycols, poly((meth)acrylic acids), polyvinylalcohols, poly(meth)acrylamides, polyurethanes, polyvinylsulfonic acids, poly(sodium styrenesulfonates), poly (sodium vinylsulfonates), poly(3-hydroxybutyric acids), polyvinylpyrrolidones, polymers of hydroxyl-substituted lower alkyl (meth)acrylates, polyamides, polyethyleneirnines, copolymers thereof, and mixtures thereof. 19. The composition of claim 18 wherein said at least one second component is a polyurethane. 20. The composition of claim 19 wherein said at least one second component is an aliphatic polyether polyurethane. 21. The composition of claim 20 wherein said aliphatic polyether polyurethane is capable of absorbing about 5 times to about 21 times its own weight in water. 22. The lubricious composition of claim 17 wherein said at least one second component is polyethylene oxide, polyvinylalcohol, polyvinylpyrrolidone, polyurethane, or mixtures thereof. 23. The lubricious composition of claim 1 wherein said at least one second component has a molecular weight of about 50,000 to about 1,500,000 g/mole. 24. The lubricious composition of claim 1 wherein said at least one second component has a weight-average molecular weight of about 75,000 to about 1,000,000 g/mole. 25. The lubricious composition of claim 1 further comprising at least one member selected from the group consisting of fillers, flow modifiers, antioxidants, coupling agents, adhesion promoters, surfactants, and mixtures thereof. 26. The lubricious composition of claim 25 further comprising at least one flow modifier which is an acrylic flow modifier. 27. The lubricious composition of claim 25 further comprising at least one coupling agent which is a silane. 28. The composition of claim 1 crosslinked by actinic radiation. 29. A lubricious composition that has been cured by actinic radiation, said lubricious composition comprising: a) at least one lubricious hydrophilic polymer; and b) at least one polymerizable alkoxylated (meth)acrylate having two or more acrylate groups wherein said at least one polymerizable alkoxylated (meth)acrylate has about 15 wt-% water solubility or greater; said polymerizable alkoxylated (meth)acrylate is a member selected from the group consisting of alkoxylated trimethylol alkane tri(meth)acrylates, alkoxylated neopentyl glycol di(meth)acrylates, alkoxylated pentaerythritol tetra(meth)acrylates, trimethylolpropane ethoxylate (1 EO/OH) methyl ether di(meth)acrylate, aromatic alkoxylated (meth) acrylates, wherein said composition is cured by actinic radiation. 30. The lubricious composition of claim 29 wherein said at least one polymerizable alkoxylated (meth)acrylate is non-aromatic. 31. The lubricious composition of claim 29 wherein said at least one polymerizable alkoxylated (meth)acrylate has greater than about 50 wt-% water solubility. 32. The lubricious composition of claim 29 wherein said at least one polymerizable alkoxylated (meth)acrylate has about 1 to about 20 moles of alkoxylation. 33. The lubricious composition of claim 32 wherein said alkoxylation is ethoxylation. 34. The lubricious composition of claim 29 wherein said at least one polymerizable alkoxylated (meth)acrylate is an ethoxylated trimethylol propane triacrylate. 35. The lubricious composition of claim 29 wherein said at least one lubricious polymer is a hydrogel. 36. The lubricious composition of claim 29 wherein said at least one lubricious polymer is selected from the group consisting of polyalkylene glycols, alkoxy polyalkylene glycols, polyalkylene oxides, poly((meth)acrylic acids), polyvinylalcohols, poly(meth)acrylamides, polyurethanes, polyvinylsulfonic acids, poly(sodium styrenesulfonates), poly (sodium vinylsulfonates), poly(3-hydroxybutyric acids), polyvinylpyrrolidones, polymers of hydroxyl-substituted lower alkyl (meth)acrylates, polyamides, polyethyleneimines, copolymers thereof, and mixtures thereof. 37. The lubricious composition of claim 29 wherein said composition is curable by ultraviolet radiation, said composition further comprising at one free radical photoinitiator. 38. The lubricious composition of claim 37 wherein said at least one photoinitiator is a benzophenone, aromatic-aliphatic ketones, α-amino ketones, benzil ketals, derivatives thereof, and mixtures thereof. 39. The lubricious composition of claim 38 wherein said at least one photoinitiator is 2-dimethoxy-2-phenyl acetophenone. 40. The lubricious composition of claim 38 wherein said at least one photoinitiator is 2-methyl 1-[4-methylthio) phenyl]2-morpholinopropan-1-one, 2-benzyl-2-(dimethylamine)-1-[4-morpholinyl)phenyl]-1-butanone or mixture thereof. 41. The lubricious composition of claim 38 further comprising an acrylated amine synergist. 42. The lubricious composition of claim 29 further comprising at least one additive selected from the group consisting of flow modifiers, coupling agents, antioxidants, surfactants and mixtures thereof. 43. The lubricious composition of claim 29 wherein said composition is admixed in a solvent or cosolvent blend. 44. The lubricious composition of claim 29 disposed on the surface of a medical device or on the surface of a component thereof said composition is cured. 45. The lubricious composition of claim 44 wherein said medical device or component thereof is a catheter shaft, dilatation balloon, guide wire lumen, guide wire or a stent retaining sleeve.
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