Topical compositions containing extracellular products and uses thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/74
A61K-035/00
A61K-039/00
A61K-039/38
A61K-039/07
A61K-035/12
A61K-035/66
A61K-035/68
A61K-035/74
A61K-035/76
A01N-063/00
A01N-025/34
A01N-063/02
C12N-001/12
C12N-001/20
출원번호
UP-0974427
(2007-10-12)
등록번호
US-7544363
(2009-07-01)
발명자
/ 주소
Farmer, Sean
출원인 / 주소
Ganeden Biotech, Inc.
대리인 / 주소
Mintz, Levin, Cohn, Ferris, Glovsky and Popeo PC
인용정보
피인용 횟수 :
8인용 특허 :
21
초록▼
The present invention discloses compositions derived from an isolated Bacillus species spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a
The present invention discloses compositions derived from an isolated Bacillus species spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain, suitable for topical application to the skin or mucosal membranes of a mammal, which are utilized to inhibit the growth of bacterium, yeast, fungi, virus, and combinations thereof. The present invention also discloses methods of treatment and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, by topical application of therapeutic compositions which are comprised, in part, of isolated Bacillus species, spores, or an extracellular product of Bacillus coagulans comprising a supernatant or filtrate of a culture of said Bacillus coagulans strain. In addition, the present invention also discloses compositions, methods of treatment, and therapeutic systems for inhibiting the growth of bacterium, yeast, fungi, virus, and combinations thereof, comprising an extracellular product of Pseudomonas lindbergii comprising a supernatant or filtrate of a culture of said Pseudomonas lindbergii strain.
대표청구항▼
What is claimed is: 1. A method of inhibiting growth of bacteria, yeast, fungus, or a virus, comprising applying to skin or a mucous membrane of a mammal in need thereof, an effective amount of a composition comprising: an extracellular product of a Bacillus coagulans strain, and an anti-fungal age
What is claimed is: 1. A method of inhibiting growth of bacteria, yeast, fungus, or a virus, comprising applying to skin or a mucous membrane of a mammal in need thereof, an effective amount of a composition comprising: an extracellular product of a Bacillus coagulans strain, and an anti-fungal agent selected from the group consisting of Amphotericin B, Carbol-Fuchsin, Ciclopirox, Clotrimzole, Econazole, Haloprogin, Ketoconazole, Mafenide, Miconazole, Naftifine, Nystatin, Oxiconazole, Silver Sulfadiazine, Sulconazole, Terbinafine, Tioconazole, Tolnafiate, and Undecylenic acid, and allowing the composition to contact said skin or mucous membrane for sufficient time to inhibit growth of bacteria, yeast, fungus, or virus. 2. The method of claim 1, wherein said composition comprises approximately 0.5% to approximately 99.9% of said Emu oil, by weight. 3. The method of claim 1, wherein said Bacillus coagulans strain is Bacillus coagulans hammer. 4. The method of claim 1, wherein said Bacillus coagulans strain comprises Bacillus coagulans hammer ATCC Accession Number 31284. 5. The method of claim 1, wherein said composition is in the form of an emulsion, cream, lotion, gel, oil, ointment, aerosol spray, or semi-solid formulation. 6. The method of claim 1, wherein said extracellular product of said Bacillus coagulans strain is a culture supematant or filtrate. 7. The method of claim 1, wherein said composition further comprises a carrier, wherein said carrier is selected from the group consisting of trehalose, malto-dextrin, rice flour, micro-crystalline cellulose, magnesium sterate, inositol, fructo-oligosaccharide, gluco-oligosaccharide, dextrose, sucrose, talc, water, physiological salt solution, urea, methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, white pertrolatum, isopropyl myristate, lanolin, lanolin alcohol, mineral oil, lavender oil, nasturtium extract oil, sorbitan mono-oleate, cetylstearyl alcohol, hydroxypropyl cellulose, detergent, sucrose stearate, sucrose cocoate, sucrose distearate, 2-ethyl-1,3-hexanediol, polyoxypropylene-15-stearyl ether, glycerol stearate, glycerin, synthetic spermaceti, cetyl alcohol, butylparaben, propylparaben and methylparaben. 8. The method of claim 1, wherein said extracellular product is a culture supematant fractionated using a method selected from the group consisting of filtration, liquid chromatography, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC). 9. A method of inhibiting growth of bacteria, yeast, fungus, or a virus, comprising applying to skin or a mucous membrane of a mammal in need thereof, an effective amount of a composition comprising: an extracellular product of a Bacillus coagulans strain, and an anti-fungal agent selected from the group consisting of Mafenide and Silver Sulfadiazine, and allowing the composition to contact said skin or mucous membrane for sufficient time to inhibit growth of bacteria, yeast, fungus, or virus. 10. The method of claim 9, wherein said composition comprises approximately 0.5% to approximately 99.9% of said Emu oil, by weight. 11. The method of claim 9, wherein said Bacillus coagulans strain is Bacillus coagulans hammer. 12. The method of claim 9, wherein said Bacillus coagulans strain comprises Bacillus coagulans hammer ATCC Accession Number 31284. 13. The method of claim 9, wherein said composition is in the form of an emulsion, cream, lotion, gel, oil, ointment, aerosol spray, or semi-solid formulation. 14. The method of claim 9, wherein said extracellular product of said Bacillus coagulans strain is a culture supernatant or filtrate. 15. The method of claim 9, wherein said composition further comprises a carrier, wherein said carrier is selected from the group consisting of trehalose, malto-dextrin, rice flour, micro-crystalline cellulose, magnesium sterate, inositol, fructo-oligosaccharide, gluco-oligosaccharide, dextrose, sucrose, talc, water, physiological salt solution, urea, methanol, ethanol, propanol, butanol, ethylene glycol, propylene glycol, white pertrolatum, isopropyl myristate, lanolin, lanolin alcohol, mineral oil, lavender oil, nasturtium extract oil, sorbitan mono-oleate, cetylstearyl alcohol, hydroxypropyl cellulose, detergent, sucrose stearate, sucrose cocoate, sucrose distearate, 2-ethyl-1,3-hexanediol, polyoxypropylene-15-stearyl ether, glycerol stearate, glycerin, synthetic spermaceti, cetyl alcohol, butylparaben, propylparaben and methylparaben. 16. The method of claim 9, wherein said extracellular product is a culture supernatant fractionated using a method selected from the group consisting of filtration, liquid chromatography, ion exchange chromatography, and High Performance Liquid Chromatography (HPLC).
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