최소 단어 이상 선택하여야 합니다.
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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | UP-0335212 (2002-12-31) |
등록번호 | US-7547287 (2009-07-01) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 115 인용 특허 : 1020 |
A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configure
A tissue penetrating system has a housing member. A plurality of penetrating members are positioned in the housing member. A tissue stabilizing member is coupled to the housing. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.
What is claimed is: 1. A tissue penetrating system, comprising: a housing member; an electrically driven drive force generator; a plurality of penetrating members positioned in the housing member, wherein each of the penetrating members is coupled to the drive force generator; a tissue stabilizing
What is claimed is: 1. A tissue penetrating system, comprising: a housing member; an electrically driven drive force generator; a plurality of penetrating members positioned in the housing member, wherein each of the penetrating members is coupled to the drive force generator; a tissue stabilizing member coupled to the housing and configured to stabilize tissue prior to a lancing event; a penetrating member position sensor coupled to the plurality of penetrating members and measures actual depth of penetration by a penetrating member based on a penetrating member contact point that is measured prior to a lancing event, a processor coupled to the penetrating member sensor and the drive force generator, operatively programmed with software that has control instructions for the electronically driven drive force generator to keep a wound tract created by a penetrating member open for a sufficient time to provide for spontaneous flow of blood for sample capture into an associated sample with a controlled blood volume of no more than 1 μL, wherein the control instructions are selected from at least one of, velocity of a penetrating member, velocity of a penetrating member in or out of target tissue and a dwell time of a penetrating member in the tissue site; and wherein a time and position of tissue contact and depth of penetration is determined in response to the processor knowing, a distance of the penetrating member tip from a target tissue, acceleration and displacement of a penetrating member, and a start position of the penetrating member. 2. The system of claim 1, wherein the tissue stabilizer member is configured to enhance fluid flow from a target tissue. 3. The system of claim 1, wherein the tissue stabilizer member creates a stretching of a skin surface. 4. The system of claim 1, wherein the tissue stabilizer member includes a plurality of protrusions. 5. The system of claim 1, wherein the tissue stabilizer member applies a vacuum to a target tissue. 6. The system of claim 1, wherein the tissue stabilizer member is configured to apply a force to a target tissue and cause the target tissue to press in an inward direction relative to the housing member. 7. The system of claim 1, wherein the tissue stabilizing device applies a stimulation to a target tissue. 8. The system of claim 1, wherein the depth of penetration is 100 to 2500 microns. 9. The system of claim 1, wherein the depth of penetration is 500 to 750 microns. 10. The system of claim 1, wherein the penetrating member sensor is further configured to provide an indication of velocity of a penetrating member. 11. The system of claim 1, further comprising: a second penetrating member sensor configured to provide an indication of velocity of a penetrating member. 12. The system of claim 1, further comprising: a feedback loop coupled to the penetrating member position sensor. 13. The system of claim 1, wherein a penetrating member driver is a voice coil drive force generator. 14. The system of claim 1, wherein the processor includes a memory for storage and retrieval of a set of penetrating member profiles utilized with the penetrating member driver. 15. The system of claim 1, wherein the processor is utilized to monitor position and speed of a penetrating member as the penetrating member moves in a first direction. 16. The system of claim 1, wherein the processor is utilized to adjust an application of force to a penetrating member to achieve a desired speed of the penetrating member. 17. The system of claim 1, wherein the processor is utilized to adjust an application of force to a penetrating member when the penetrating member contacts a target tissue so that the penetrating member penetrates the target tissue within a desired range of speed. 18. The system of claim 1, wherein the processor is utilized to monitor position and speed of a penetrating member as the penetrating member moves in the first direction toward a target tissue, wherein the application of a launching force to the penetrating member is controlled based on position and speed of the penetrating member. 19. The system of claim 1, wherein the processor is utilized to control a withdraw force to the penetrating member so that the penetrating member moves in a second direction away from a target tissue. 20. The system of claim 1, wherein in the first direction the penetrating member moves toward the target tissue at a speed that is different than a speed at which the penetrating member moves away from a target tissue. 21. The system of claim 1, wherein in a first direction the penetrating member moves toward the target tissue at a speed that is greater than a speed at which the penetrating member moves away from a target tissue. 22. The system of claim 20, wherein a speed of a penetrating member in the first direction is the range of 0.05 to 60 m/sec. 23. The system of claim 20, wherein a speed of a penetrating member in the first direction is the range of 0.1 to 20.0 m/sec. 24. The system of claim 20, wherein a speed of a penetrating member in the first direction is the range of 1.0 to 10.0 m/sec. 25. The system of claim 20, wherein a speed of a penetrating member in the first direction is the range of 3.0 to 8.0 m/sec. 26. The system of claim 20, wherein a dwell time of the penetrating member in a target tissue below a skin surface is in the range of 1 microsecond to 2 seconds. 27. The system of claim 1, wherein a dwell time of the penetrating member in a target tissue below a skin surface is in the range of 500 milliseconds to 1.5 second. 28. The system of claim 1, wherein a dwell time of the penetrating member in a target tissue below a skin surface is in the range of 100 milliseconds to 1 second. 29. The system of claim 1, further comprising: a plurality of disposables integrated in a cassette. 30. The system of claim 29, wherein each disposable has an exit port, and upon launch each penetrating member exists from the exit port. 31. The system of claim 1, wherein the penetrating member position sensor includes a capacitive incremental encoder. 32. The system of claim 1, wherein the penetrating member position sensor includes an incremental encoder. 33. The system of claim 1, wherein the penetrating member position sensor includes an optical encoder. 34. The system of claim 1, wherein the penetrating member position sensor includes an interference encoder. 35. The system of claim 1, further comprising: an analyte detecting member. 36. The system of claim 1, further comprising: a plurality of analyte detecting members each coupled to a penetrating member. 37. The system of claim 1, wherein the sample chamber is sized to receive no more than 0.75 μL of the body fluid. 38. The system of claim 1, wherein the sample chamber is sized to receive no more than 0.5 μL of the body fluid. 39. The system of claim 1, wherein the sample chamber is sized to receive no more than 0.25 μL of the body fluid. 40. The system of claim 1, wherein the sample chamber is sized to receive no more than 0.1 μL of the body fluid. 41. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 1 μL of a body fluid disposed in the sample chamber. 42. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.75 μL of a body fluid disposed in the sample chamber. 43. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.5 μL of a body fluid disposed in the sample chamber. 44. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.25 μL of a body fluid disposed in the sample chamber. 45. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.1 μL of a body fluid disposed in the sample chamber. 46. The system of claim 1, wherein each of a penetrating member of the plurality of penetrating members has a packing density of no more than 1.0 cm3/penetrating member. 47. The system of claim 1, wherein each of a penetrating member of the plurality of penetrating members has a packing density of no more than 0.75 cm3/penetrating member. 48. The system of claim 1, wherein the each of a penetrating member of the plurality of penetrating members has a packing density of no more than 0.5 cm3/penetrating member. 49. The system of claim 1, wherein each of a penetrating member of the plurality of penetrating members has a packing density of no more than 0.25 cm3/penetrating member. 50. The system of claim 1, wherein each of a penetrating member of the plurality of penetrating members has a packing density of no more than 0.1 cm3/penetrating member. 51. The system of claim 1, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 1.0 cm3. 52. The system of claim 1, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 0.75 cm3. 53. The system of claim 1, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 0.5 cm3. 54. The system of claim 1, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 0.25 cm3. 55. The system of claim 1, wherein each of a penetrating member and an associated sample chamber have a combined packing density of no more than 0.1 cm3. 56. The system of claim 1, further comprising: a seal formed by a fracturable material between the penetrating member and a disposable, the seal being positioned at least one of a distal port or a proximal port of the disposable. 57. The system of claim 56, further comprising a second fracturable seal located at least one of the distal port or proximal port of disposable. 58. The system of claim 1, wherein each penetrating member is an elongated member without molded attachments. 59. The system of claim 1, further comprising: a penetrating member transport device for moving each of a penetrating member into a position aligned with the penetrating member driver. 60. The system of claim 1, further comprising, a belt for holding the penetrating members in an array configuration. 61. The system of claim 1, further comprising: a tape device configured to hold the penetrating members in an array configuration. 62. The system of claim 1, further comprising: a support channel configured to hold the penetrating members in an array configuration. 63. The system of claim 1, further comprising: a cog configured to hold the penetrating members in an array configuration. 64. The system of claim 1, further comprising: a plurality of connectors between penetrating members for holding the penetrating members in an array configuration. 65. The system of claim 1 further comprising: a support structure for receiving the penetrating members. 66. The system of claim 65, wherein the support structure is a bandolier. 67. The system of claim 65, wherein the support structure is a drum. 68. The system of claim 65, wherein the support structure is a disc.
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