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Methods for drug discovery, disease treatment, and diagnosis using metabolomics 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/00
출원번호 UP-0728827 (2007-03-27)
등록번호 US-7550260 (2009-07-01)
발명자 / 주소
  • Kaddurah Daouk, Rima
  • Kristal, Bruce S.
출원인 / 주소
  • Metabolon, Inc.
  • Cornell Research Foundation, Inc.
대리인 / 주소
    McCarter & English, LLP
인용정보 피인용 횟수 : 10  인용 특허 : 31

초록 ▼

The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are a

대표청구항

대표청구항이 없습니다.

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  1. Chace Donald H., Clinical method for the genetic screening of newborns using tandem mass spectrometry.
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  5. Dasseux, Jean-Louis H.; Newton, Roger S.; Rea, Thomas J.; Bisgaier, Charles L.; Pape, Michael E., Fourier transform mass spectrometry of complex biological samples.
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  6. Ward Eric R. (Durham NC) Volrath Sandra (Durham NC) Koizumi Shinichi (Nishinomiya JPX) Tada Sachiyo (Osaka JPX) Mori Ichiro (Hyogo JPX) Iwasaki Genji (Hyogo JPX), Herbicide resistant plants.
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  8. Matson Wayne R. (Ayer MA), Liquid chromatograph with electrochemical detector and method.
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  9. Matson Wayne R. (Ayer MA), Method for biological testing and/or developing pharmaceuticals for treatment of disorders.
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  10. Matson Wayne R. (Ayer MA), Method for biological testing and/or developing pharmaceuticals for treatment of disorders using electrochromatography.
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  11. McLeod Malcolm N., Method for facilitating diagnosis of a psychiatric disorder.
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  12. Nova Michael P. ; Potash Hanan ; Xiao Xiao-Yi ; Parandoosh Zahra ; David Gary S., Method for tagging and screening molecules.
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  13. Forssmann Wolf-Georg,DEX ; Raida Manfred,DEX ; Brenner Bernhard,DEX ; Nier Volker,DEX, Method for the direct diagnostic detection of genetically caused pathogenic point mutations.
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  14. Burcoglu Arsinur, Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states.
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  15. Martin William Frank,DEX ; Hain Ruediger,DEX ; Tietjen Klaus-Guenther,DEX ; Busch Marco,DEX ; Kloti Andreas S., Method of determining activity of 1-deoxy-D-xylulose-5-phosphate reductoisomerase and 1-deoxy-D-xylulose-5-phosphate synthase.
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  16. Matson Wayne R., Method of diagnosing or categorizing disorders from biochemical profiles.
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  17. Matson Wayne R., Method of diagnosing or categorizing disorders from biochemical profiles.
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  18. Kristal, Bruce S.; Matson, Wayne R.; Milbury, Paul E., Methodology for predicting and/or diagnosing disease.
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  19. Chong-Sheng Yuan, Methods and compositions for assaying analytes.
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  20. Stockman, Brian J.; Farley, Kathleen A.; Dalvit, Claudio, Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules.
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  21. Siman Robert, Methods for detecting calpain activation and identifying calpain inhibitors.
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  22. Rice John W. ; Kloti Andreas S. ; Crawford ; Jr. John M. ; Lanning Beth ; Stewart Sandy J., Methods for determining deoxyxylulose 5-phosphate synthase activity.
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  23. Kaddurah Daouk,Rima; Kristal,Bruce, Methods for drug discovery, disease treatment, and diagnosis using metabolomics.
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  24. Kaddurah Daouk,Rima; Kristal,Bruce, Methods for drug discovery, disease treatment, and diagnosis using metabolomics.
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  25. Mascarenhas Desmond, Methods for predicting drug response.
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  27. Kaser Matthew R. ; Hillman Jennifer L. ; Baughn Mariah R., Phospholipid transfer protein.
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  28. Wang Bruce, Quantitative microarray hybridizaton assays.
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  29. Kornelia Polyak ; Bert Vogelstein ; Kenneth W. Kinzler, Subtle mitochondrial mutations as tumor markers.
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  30. Geoffrey N. Roth ; Jonathan N. Roth, Test media and quantitative or qualitative method for identification and differentiation of biological materials in a test sample.
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  31. Lelievre Sophie ; Bissell Mina, Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders.
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