[특허]Synergistic treatment of cancer using immunomers in conjunction with therapeutic agents

Synergistic treatment of cancer using immunomers in conjunction with therapeutic agents 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-039/395 A61K-031/7105 A61K-031/7115 A61K-031/7125
출원번호	UP-0846167 (2004-05-14)
등록번호	US-7569554 (2009-08-24)
발명자 / 주소	Kandimalla, Ekambar R. Agrawal, Sudhir Wang, Daqing Bhagat, Lakshmi Yu, Dong
출원인 / 주소	Idera Pharmaceuticals, Inc.
대리인 / 주소	Keown, Wayne A.
인용정보	피인용 횟수 : 8 인용 특허 : 9

초록

The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers in combination with chemotherapeutic agents to provide a synergistic therapeutic effect.

대표청구항 ▼

What is claimed is: 1. A method for treating cancer comprising administering to a patient an immunomer in combination with a monoclonal antibody selected from Panorex® (edrecolomab), Rituxan® (rituximab), Mylotarg® (gemtuzumab ozogamicin), Campath® (alemtuzumab), Zevalin® (ibritumomab tiuxetan), Bexxar® (tositumomab), Erbitux® (cetuximab), Avastin® (bevacizumab or Herceptin® (trastuzumab), wherein the immunomer comprises the structure 5'-TCGTTGX-Y-XGTTGCT-5' wherein X is a C3 linker and Y is a glycerol linker or comprises the structure (SEQ ID NO 18): and wherein the anti-tumor effects of the monoclonal antibody are enhanced when administered in combination with the immunomer. 2. A pharmaceutical formulation comprising an immunomer, wherein the immunomer comprises the structure 5 '-TCGTTGX-Y-XGTTGCT-5' wherein X is a C3 linker and Y is a glycerol linker or comprises the structure (SEQ ID NO 18): a monoclonal antibody selected from Panorex® (edrecolomab), Rituxan® (rituximab), Mylotarg® (gemtuzumab ozogamicin), Campath® (alemtuzumab), Zevalin® (ibritumomab tiuxetan), Bexxar® (tositumomab), Erbitux® (cetuximab), Avastin® bevacizumab or Herceptin® (trastuzumab) and a physiologically acceptable carrier.

이 특허에 인용된 특허 (9)

Agrawal Sudhir ; Habus Ivan ; Kandimalla Ekambar R., Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides.
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Metelev Valeri (Shrewsbury MA) Agrawal Sudhir (Shrewsbury MA), Hybrid oligonucleotide phosphorothioates.
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Metelev Valeri,RUX ; Agrawal Sudhir, Hybrid oligonucleotide phosphorothioates.
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Valeri Metelev RU; Sudhir Agrawal, Hybrid oligonucleotide phosphorothioates.
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Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
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Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
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Agrawal,Sudhir; Kandimalla,Ekambar R.; Yu,Dong; Bhagat,Lakshmi, Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends.
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Sudhir Agrawal ; Qiuyan Zhao, Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal.
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Heather L. Davis CA; Joachim Schorr DE; Arthur M. Krieg, Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant.
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이 특허를 인용한 특허 (8)

Epstein, David; Grate, Dilara; Stanton, Martin; Diener, John L.; Wilson, Charles; McCauley, Thomas Greene; Desouza, Errol, Aptamers comprising CPG motifs.
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Agrawal, Sudhir; Kandimalla, Ekambar R.; Yu, Dong; Bhagat, Lakshmi, Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends.
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Agrawal, Sudhir; Kandimalla, Ekambar R.; Yu, Dong; Bhagat, Lakshmi, Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends.
상세보기
Agrawal, Sudhir; Kandimalla, Ekambar R.; Yu, Dong; Bhagat, Lakshmi, Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends.
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Agrawal, Sudhir; Kandimalla, Ekambar R.; Yu, Dong; Bhagat, Lakshmi, Short immunomodulatory oligonucleotides.
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McCauley, Dilara; Diener, John L.; Wilson, Charles; McCauley, Thomas Greene, Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics.
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Hlavinka, Mark L.; Yang, Qing; Murph, Mandi Michelle, Use of metallocene compounds for cancer treatment.
상세보기
Hlavinka, Mark L.; Yang, Qing; Murph, Mandi Michelle, Use of metallocene compounds for cancer treatment.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Synergistic treatment of cancer using immunomers in conjunction with therapeutic agents 원문보기