IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
UP-0425096
(2006-06-19)
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등록번호 |
US-7572610
(2009-08-25)
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발명자
/ 주소 |
- Laszlo, Joseph A.
- Compton, David L.
- DeFilippi, Louis J.
- Grall, Steven
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출원인 / 주소 |
- Biotechnology Research & Development Corporation
- The United States of America as represented by the Department of Agriculture
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
2 인용 특허 :
10 |
초록
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A method of making a compound having the structural formula: wherein at least two of R1, R2, and R3 are non-fatty acid carboxylates, and the other of R1, R2, and R3 are each either a C2-C24 fatty acid moiety, OH, or a non-fatty acid carboxylate, wherein the first and second non-fatty acid carboxy
A method of making a compound having the structural formula: wherein at least two of R1, R2, and R3 are non-fatty acid carboxylates, and the other of R1, R2, and R3 are each either a C2-C24 fatty acid moiety, OH, or a non-fatty acid carboxylate, wherein the first and second non-fatty acid carboxylates, when present, are the same or different, comprising (a) partially deacylating a triacylglycerol so as to provide a mono-or diacylglycerol, (b) reacting in a reaction mixture an acyl ester of the phytochemical with said mono-or diacylglycerol in the presence of a esterase catalyst under conditions that permit transesterification of said ester with said mono-or diacylglycerol, and (c) recovering said compound from said reaction mixture.
대표청구항
▼
What is claimed is: 1. A method of making a compound having the structural formula: wherein at least two of R1, R2, and R3 are non-fatty acid carboxylates; and the other of R1, R2, and R3 are each either a C2-C24 fatty acid moiety, OH, or a non-fatty acid carboxylate, wherein the first and second
What is claimed is: 1. A method of making a compound having the structural formula: wherein at least two of R1, R2, and R3 are non-fatty acid carboxylates; and the other of R1, R2, and R3 are each either a C2-C24 fatty acid moiety, OH, or a non-fatty acid carboxylate, wherein the first and second non-fatty acid carboxylates are the same or different and wherein at least one R1, R2, and R3 comprises a phytochemical, comprising: (a) partially deacylating a triacylglycerol so as to provide a mono-or diacylglycerol wherein the triglycerol is a vegetable oil selected from the group consisting of soybean oil, corn oil, sunflower seed oil, high-oleic sunflower seed oil, canola oil, safflower oil, cuphea oil, coconut oil, olive oil, palm kernel oil and combinations thereof; (b) reacting in a reaction mixture an acyl ester of the phytochemical with said mono-or diacylglycerol in the presence of a esterase catalyst under conditions that permit transesterification of said ester with said mono-or diacylglycerol; (c) recovering said compound from said reaction mixture; and (d) removing volatile compounds from the reaction mixture prior to or following recovering said compound from said reaction mixture. 2. The method of claim 1 wherein (a) is carried out in the presence of an esterase catalyst. 3. The method of claim 1 wherein said reaction mixture is substantially free of water. 4. The method of claim 1 wherein the two non-fatty acid carboxylates absorb UV radiation. 5. The method of claim 1 wherein the two non-fatty acid carboxylates have at least one property selected from the group consisting of anti-aging properties, anti-bacterial, anti-viral, anti-neoplastic properties, and antioxidant properties. 6. The method of claim 1 wherein the two non-fatty acid carboxylates are compounds comprising at least one UV-absorbing chromophore. 7. The method of claim 6 wherein the compound comprising at least one UV-absorbing chromophore is the phytochemical. 8. The method of claim 7 wherein the phytochemical is selected from the group consisting of a flavonoid, an isoflavone (phytoestrogen), an isothiocyanate, an organosulfur compound, a saponin, capsaicin, and combinations thereof. 9. The method of claim 7 wherein the phytochemical is selected from the group consisting of an aromatic species, an unsaturated isoprenoid, an unsaturated terpenoid, a hindered hydroxy-substituted cinnamic acid, an unhindered hydroxy-substituted cinnamic acid, and combinations thereof. 10. The method of claim 9 wherein the hydroxy-substituted cinnamic acid is substituted at positions 2, 3, 4, 5, 6 or combinations thereof. 11. The method of claim 7 wherein the phytochemical comprises maleanilic acid, homovanillic acid, folic acid, crocetin, coumaric acid, caffeic acid, ferulic acid, sinapic acid (sinapinic acid), derivatives thereof or combinations thereof. 12. The method of claim 1 wherein the compound has the formula: wherein R4=H or OCH3 and either of R2, or R3 or both R2 and R3 are non-fatty acid carboxylates comprising compounds comprising a UV-absorbing chromophore and wherein the compounds comprising at least one UV-absorbing chromophore comprises the phytochemical. 13. The method of claim 1 wherein the acyl ester is ethyl ferulate. 14. The method of claim 1 wherein (a) is carried out prior to (b). 15. The method of claim 1 wherein (a) comprises an alcoholysis or glycerolysis reaction. 16. The method of claim 1 wherein (a) comprises partial hydrolysis of a triacylglycerol. 17. A method of making a compound comprising a triacylglycerol esterified with at least a first carboxylate, comprising: (a) providing a mono-or diacylglycerol; (b) reacting in a reaction mixture an acyl ester of the first carboxylate with said mono-or diacylglycerol in the presence of a esterase catalyst under conditions that permit transesterification of said ester with said mono-or diacylglycerol; and (c) recovering the compound from said reaction mixture wherein (a) comprises partial transesterification of glycerol with free fatty acids and wherein (b) is carried out in the substantial absence of a solvent. 18. The method of claim 17 wherein the first carboxylate is a phytochemical. 19. The method of claim 17 wherein (b) is carried out in the substantial absence of water. 20. A method of making a compound having the structural formula: wherein at least two of R1, R2, and R3 are non-fatty acid carboxylates; and the other of R1, R2, and R3 are each either a C2-C24 fatty acid moiety, OH, or a non-fatty acid carboxylate, wherein the first and second non-fatty acid carboxylates, are the same or different and wherein at least one of the non-fatty acid carboxylates comprises a phytochemical, comprising: (a) partially deacylating a triacylglycerol so as to provide a mono-or diacylglycerol wherein the triglycerol is a vegetable oil; (b) reacting in a reaction mixture an acyl ester of the phytochemical with said mono-or diacylglycerol in the presence of a esterase catalyst under conditions that permit transesterification of said ester with said mono-or diacylglycerol; (c) recovering said compound from said reaction mixture; and (d) removing at least a portion of the vegetable oil from the reaction mixture prior to or following recovery of the compound from said reaction mixture. 21. The method of claim 20 wherein the vegetable oil is selected from the group consisting of soybean oil, corn oil, sunflower seed oil, high-oleic sunflower seed oil, canola oil, safflower oil, cuphea oil, coconut oil, olive oil, palm kernel oil and combinations thereof. 22. The method of claim 20 wherein the phytochemical is selected from the group consisting of a flavonoid, a isoflavone (phytoestrogen), an isothiocyanate, an organosulfur compound, a saponin, capsaicin, or combinations thereof. 23. The method of claim 20 wherein the phytochemical is selected from the group consisting of an aromatic specie, an unsaturated isoprenoid, an unsaturated terpenoid, a hindered hydroxy-substituted cinnamic acid, an unhindered hydroxy-substituted cinnamic acid, or combinations thereof. 24. The method of claim 20 wherein the C2-C24 fatty acid moiety has a degree of saturation of from saturated to hexaunsaturated.
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