초록 ▼

An iontophoresis device includes: an active electrode element operable to provide an electrical potential; an inner active agent reservoir comprising: a first compartment having a diluent; a second compartment having an active agent; and a polymer complex layer disposed between the first compartment

An iontophoresis device includes: an active electrode element operable to provide an electrical potential; an inner active agent reservoir comprising: a first compartment having a diluent; a second compartment having an active agent; and a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding. The polymer complex is electrically responsive and disintegrates when an electrical field is applied. The active agent and the diluent become mixed to form a transient solution or dispersion prior to administration of the active agent

대표청구항 ▼

I claim: 1. An iontophoresis device for delivering active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including: an active electrode element operable to provide an electric

I claim: 1. An iontophoresis device for delivering active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including: an active electrode element operable to provide an electrical potential; and an inner active agent reservoir comprising: a first compartment having a diluent; a second compartment having an active agent; and a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding, wherein, when the electrical potential is applied to the active electrode, the polymer complex layer disintegrates to allow the active agent and the diluent to mix. 2. The iontophoresis device of claim 1 wherein the first hydrophilic polymer comprising a plurality of electron-deficient groups. 3. The iontophoresis device of claim 1 wherein the second hydrophilic polymer comprising a plurality of electron-rich groups. 4. The iontophoresis device of claim 1 where the polymer complex is a complex of poly((meth)acrylic acid) and poly(acrylamide), a complex of poly((meth)acrylic acid) and poly(vinyl alcohol), a complex of poly((meth)acrylic acid) and poly(ethylene glycol), a complex of poly((meth)acrylic acid) and poly(N-vinylpyrrolidone) or a complex of poly((meth)acrylic acid) and poly(ethyloxazoline). 5. The iontophoresis device of claim 4 wherein the polymer complex forms at a critical pH value. 6. The iontophoresis device of claim 5 wherein, when the electrical potential is applied to the active electrode, hydroxide ions migrate toward the polymer complex layer to increase a local pH value, and the polymer complex layer disintegrates when the local pH reaches above the critical pH value. 7. The iontophoresis device of claim 1 wherein the polymer complex is in solid form. 8. The iontophoresis device of claim 1 wherein the polymer complex is in gel form. 9. The iontophoresis device of claim 1 wherein the diluent is aqueous. 10. The iontophoresis device of claim 1 wherein the active agent is in solid form. 11. The iontophoresis device of claim 1 wherein the active agent is in a stable solution form. 12. The iontophoresis device of claim 1 wherein the active agent is more stable in the second compartment than when it is mixed with the diluent. 13. The iontophoresis device of claim 1, further comprising: an electrolyte reservoir disposed between the active electrode element and the inner active agent reservoir. 14. The iontophoresis device of claim 1, further comprising: an inner ion selective membrane disposed between said electrolyte reservoir and said inner active agent reservoir. 15. The iontophoresis device of claim 1, further comprising: an outermost ion selective membrane having an outer surface, the outer surface being proximate the biological interface when in use. 16. The iontophoresis device of claim 15, further comprising: a second active agent cached in the outermost ion selective membrane. 17. The iontophoresis device of claim 15, further comprising: a third active agent deposited on the out surface of the outermost ion selective membrane. 18. The iontophoresis device of claim 15, further comprising: an outer release liner underlying said outer surface, said outer release liner being proximate the biological interface when in use. 19. The iontophoresis device of claim 1, further comprising: a microneedle array contacting an outer surface of the iontophoresis device. 20. A method for transdermal administration of an active agent by iontophoresis, comprising: positioning an active electrode assembly and a counter electrode assembly of an iontophoresis device on a biological interface of a subject, the active electrode assembly further including an active electrode element operable to provide an electrical potential; and an inner active agent reservoir comprising a first compartment having a diluent, a second compartment having an active agent, and a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding; and applying a sufficient amount of electrical current to cause the polymer complex layer to disintegrate such that the diluent and the active agent are mixed, and to administer a therapeutically effective amount of the active agent in the subject for a limited period of time. 21. The method of claim 20 wherein applying the sufficient amount of current includes electrochemically reducing water to produce hydroxide ions. 22. The method of claim 21 wherein the hydroxide ions weaken the hydrogen bonding and cause the polymer complex layer to disintegrate. 23. The method of claim 21 wherein the active agent is more stable in the second compartment than when it is mixed with the diluent. 24. The method of claim 21 where the polymer complex is a complex of poly((meth)acrylic acid) and poly(acrylamide), a complex of poly((meth)acrylic acid) and poly(vinyl alcohol), a complex of poly((meth)acrylic acid) and poly(ethylene glycol), a complex of poly((meth)acrylic acid) and poly(N-vinylpyrrolidone) or a complex of poly((meth)acrylic acid) and poly(ethyloxazoline).