IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
UP-0835359
(2004-04-28)
|
| 등록번호 |
US-7575739
(2009-08-31)
|
|
발명자
/ 주소 |
- Tamarkin, Dov
- Friedman, Doron
- Eini, Meir
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
Wilmer Cutler Pickering Hale and Dorr LLP
|
| 인용정보 |
피인용 횟수 :
59 인용 특허 :
194 |
초록
▼
The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolve
The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolves into foam, which is effective in the topical treatment and prevention of various skin disorders.
대표청구항
▼
What is claimed is: 1. A foamable composition comprising a. about 0.1% to about 5% by weight iodine; b. about 80% to about 99.6% by weight of at least one solvent; c. about 0.1% to about 5% by weight of at least one foam adjuvant comprising at least one fatty alcohol, at least one fatty acid, or a
What is claimed is: 1. A foamable composition comprising a. about 0.1% to about 5% by weight iodine; b. about 80% to about 99.6% by weight of at least one solvent; c. about 0.1% to about 5% by weight of at least one foam adjuvant comprising at least one fatty alcohol, at least one fatty acid, or a mixture thereof; and d. about 0.1% to about 5% by weight of at least one surface active agent; and e. a liquefied or compressed gas propellant, wherein the weight ratio of the propellant to the remainder of the composition is about 3:97 to about 25.75, said composition housed in a pressurized container comprising a valve configured to release said composition as breakable foam. 2. The composition claim 1, having specific gravity of about 0.02 gr/ml to about 0.35 gr/ml. 3. The composition of claim 1, wherein the iodine is selected from native iodine and complexed iodine. 4. The composition of claim 3, wherein the complexed iodine is selected from cadexomer-iodine, diiodhydrin, domiodol, hydriodic acid, iodinated glycerol, iodoform, and povidone-iodine. 5. The composition of claim 1, wherein the at least one solvent comprises water. 6. The composition of claim 5, further comprising a water miscible organic solvent. 7. The composition of claim 6, wherein the water miscible organic solvent is selected from the group consisting of a polyhydroxy solvent and a poly-ethoxylated compound. 8. The composition of claim 7, wherein the polyhydroxy solvent is selected from the group consisting of ethylene glycol, propylene glycol, glycerol, butanediols and isomers thereof, pentaerythritol, sorbitol, mannitol, dimethyl isosorbide, polyethylene glycol, polypropylene glycol, diethylene glycol monoethyl ether and mixtures thereof. 9. The composition of claim 7, wherein the poly-ethoxylated compound is selected from the group consisting of polyethylene glycol, tetrahydrofurfuryl alcohol and polyethyleneglycol. 10. The composition of claim 6, wherein the water to water miscible organic solvent ratio is in the range of about 1:10 to about 10:1. 11. The composition of claim 1, wherein the at least one surface active agent is selected from the group consisting of anionic surface active agents, cationic surface active agents, nonionic surface active agents, zwitterionic surface active agents, amphoteric surface active agents, ampholytic surface active agents and mixtures thereof. 12. The composition of claim 11, wherein the at least one surface-active agent is a mixture of a non-ionic surface-active agent and an ionic surface-active agent. 13. The composition of claim 12, wherein the non-ionic surface active agent to ionic surface active agent weight ratio is in the range of about 4:1 to about 1:4. 14. The composition of claim 12, wherein the non-ionic surface acting agent to ionic surface acting agent weight ratio is in the range of about 2:1 to about 1:2. 15. The composition of claim 11, wherein the at least one surface-active agent has a HLB value higher than about 8. 16. The composition of claim 1, wherein the at least one foam adjuvant is selected from a fatty alcohol, a fatty acid and a hydroxy fatty acid and mixtures thereof. 17. The composition of claim 1, wherein the at least one foam adjuvant comprises between about 0.4% and about 2.5% of the composition. 18. The composition of claim 1, wherein the at least one surface active agent is a nonionic surface active agent. 19. The composition of claim 12, wherein the ratio of non-ionic to ionic surface active agent is about 3:2. 20. The composition of claim 12, wherein the ionic surface active agent comprises a zwitterionic surface active agent and the ratio of zwitterionic to non-ionic surface active agent is about 1:2. 21. The composition of claim 12, wherein the ionic surface active agent comprises an anionic surface active agent and the amount of anionic surface active agent is about the same as or is less than the amount of non-ionic surface active agent. 22. The composition of claim 1, further comprising about 0.1% to about 5% by weight of at least one gelling agent. 23. The composition of claim 22, wherein the at least one gelling agent comprises naturally-occurring polymeric materials, chemically modified starches, semi-synthetic polymeric materials, synthetic polymeric materials, acrylic acid/ethyl acrylate copolymers and carboxyvinyl polymers. 24. The composition of claim 22, wherein the at least one gelling agent comprises locust bean gum, guar gum, sodium alginate, sodium caseinate, egg albumin, gelatin agar, carrageenin gum, sodium alginate, xanthan gum, quince seed extract, tragacanth gum, starch, a cellulose ether, hydroxypropyl guar gum, soluble starch, cationic cellulose, cationic guar, a carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, a polyacrylic acid polymer, a polymethacrylic acid polymer, a polyvinyl acetate polymer a, a polyvinyl chloride polymer, a polyvinylidene chloride polymer, a polyalkenyl polyether cross-linked polymer of acrylic acid, or a mixture thereof. 25. The composition of claim 22, wherein the at least one gelling agent comprises hydroxypropylmethyl cellulose, hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, or a mixture thereof.
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