Aerosol formulation for inhalation comprising an anticholinergic
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/00
A61K-031/46
C07D-007/02
C07D-007/00
A61M-015/00
A61M-015/08
A61K-009/00
A61K-009/12
A61K-009/14
출원번호
UP-0935502
(2004-09-07)
등록번호
US-7579358
(2009-09-08)
우선권정보
DE-103 45 065(2003-09-26)
발명자
/ 주소
Boeck, Georg
Schmidt, Friedrich
출원인 / 주소
Boehringer Ingelheim International GmbH
대리인 / 주소
Morris, Michael P.
인용정보
피인용 횟수 :
15인용 특허 :
36
초록
A pharmaceutical composition comprising: (a) an active substance consisting of a compound of formula 1 wherein X- is an anion; (b) ethanol or a mixture of ethanol and water; (c) a pharmacologically acceptable acid.
대표청구항▼
What is claimed is: 1. A pharmaceutical composition comprising: (a) an active substance consisting of a compound of formula 1 wherein X- is an anion; (b) ethanol or a mixture of ethanol and water; and (c) a pharmacologically acceptable acid, wherein the composition is propellant-free and has a p
What is claimed is: 1. A pharmaceutical composition comprising: (a) an active substance consisting of a compound of formula 1 wherein X- is an anion; (b) ethanol or a mixture of ethanol and water; and (c) a pharmacologically acceptable acid, wherein the composition is propellant-free and has a pH from 2.5 to 6.5. 2. The pharmaceutical composition according to claim 1, further comprising a pharmacologically acceptable excipient or complexing agent. 3. The pharmaceutical composition according to claim 1, wherein X- is chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate, or p-toluenesulfonate. 4. The pharmaceutical composition according to claim 1, wherein X- is chloride, bromide, p-toluenesulfonate, or methanesulfonate. 5. The pharmaceutical composition according to claim 1, wherein component (b) is a mixture of ethanol and water. 6. The pharmaceutical composition according to claim 5, wherein the proportion by mass of ethanol in component (b) is in the range from 5% to 99%. 7. The pharmaceutical composition according to claim 5, wherein the proportion by mass of ethanol in component (b) is in the range from 10% to 96%. 8. The pharmaceutical composition according to one of claims 1 to 7, wherein the pharmacologically acceptable acid is hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid, phosphoric acid, ascorbic acid, citric acid, malic acid, tartaric acid, maleic acid, succinic acid, fumaric acid, acetic acid, formic acid, or propionic acid. 9. The pharmaceutical composition according to one of claims 1 to 7, wherein the content of 1' is about 4 mg to 2000 mg per 100 mL of the composition. 10. The pharmaceutical composition according to claim 1, further comprising a complexing agent. 11. The pharmaceutical composition according to claim 10, wherein the amount of complexing agent is 1 mg to 100 mg per 100 mL of solution. 12. The pharmaceutical composition according to claim 1, further comprising benzalkonium chloride. 13. The pharmaceutical composition according to claim 10, wherein the amount of benzalkonium chloride is 1 mg to 50 mg per 100 mL of solution. 14. The pharmaceutical composition according to claim 1, wherein the composition has a pH from 3.0 to 5.0. 15. The pharmaceutical composition according to claim 14, wherein the composition has a pH from 3.5 to 4.5. 16. A nebulizer containing the pharmaceutical composition according to one of claims 1 to 7.
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