Compact system for packaging injectable liquid products into containers in a sterile environment
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B65B-055/02
A61L-002/00
출원번호
UP-0795133
(2006-01-11)
등록번호
US-7581367
(2009-09-16)
우선권정보
IT-B02005A000010(2005-01-12)
국제출원번호
PCT/EP06/000167
(2006-01-11)
§371/§102 date
20070712
(20070712)
국제공개번호
WO06/074904
(2006-07-20)
발명자
/ 주소
Bechini, Claudio
출원인 / 주소
IMA Industria Macchine Automatiche S.p.A.
대리인 / 주소
Nixon & Vanderhye P.C.
인용정보
피인용 횟수 :
3인용 특허 :
18
초록▼
A compact system for packaging sterile pharmaceutical liquid products injectable into suitable containers in a sterile environment comprises a plurality of operative packaging stations connected together and arranged in succession along an advancing path of said containers; the plurality of stations
A compact system for packaging sterile pharmaceutical liquid products injectable into suitable containers in a sterile environment comprises a plurality of operative packaging stations connected together and arranged in succession along an advancing path of said containers; the plurality of stations comprises at least a washing station intended for cleaning and decontaminating each of the said containers, at least a sterilizing station for sterilizing the containers exiting said washing station, and at least a filling and sealing station for filling said containers with said liquids and for sealing said containers; said stations and a connecting arrangement thereof are mounted in an operating configuration on a sole work platform; the washing station and the sterilizing station being arranged parallel and alongside one another, and connected together by a first conveyor of the containers arranged transversely to the washing station and to the sterilizing station to define a first substantially "U"-shaped portion of said path; the filling and sealing station being arranged aligned on said washing station and connected, in a staggered position, to the sterilizing station by a second conveyor of said containers arranged transversely to the sterilizing station, to define a second substantially "L"-shaped portion of the advancing path.
대표청구항▼
The invention claimed is: 1. Compact system for packaging liquid products in a sterile environment, in particular pharmaceutical liquids injectable into suitable containers, the system comprising a plurality of operative packaging stations connected together and arranged in succession along an adva
The invention claimed is: 1. Compact system for packaging liquid products in a sterile environment, in particular pharmaceutical liquids injectable into suitable containers, the system comprising a plurality of operative packaging stations connected together and arranged in succession along an advancing path of said containers; said plurality of stations comprising at least a washing station intended for cleaning and decontaminating each of the said containers, at least a sterilising station for sterilising the containers exiting said washing station, and at least a filling and sealing station for filling said containers with said liquids and for sealing the containers; wherein said stations and a connecting arrangement thereof are mounted in an operating configuration on a sole work platform; said washing station and said sterilising station being arranged parallel to one another and placed alongside and connected together by a first conveyor of the containers arranged transversely to the washing station and the sterilising station to define a first substantially "U"-shaped portion of said path; said filling and sealing station being arranged aligned on said washing station and connected, in a staggered position, to said sterilising station by a second conveyor of said containers arranged transversely to the sterilising station to define a second substantially "L"-shaped portion of said advancing path; wherein said sterilising station comprises a two-stage sterilising/depyrogenating unit; said two-stage sterilising/depyrogenating unit being enclosed inside an insulated covering structure. 2. System according to claim 1, wherein said work platform defines a work area with an extent substantially the same as that of a loading plane of a standard road transport vehicle, so as to be compatible with loading and conveying of the entire system mounted on the loading plane. 3. System according to claim 1, wherein said washing station comprises a conveying plane for supporting and advancing in an orderly manner said containers to a grasping, moving and washing device; said grasping, moving and washing device comprises at least a conveyor provided with a grasping arrangement for grasping in succession groups of said containers from said conveying plane at a first operating position, and at least a bank of dispensing and diffusing nozzles for dispensing and diffusing liquid washing substances inside the containers; the station further comprising an actuating arrangement for moving with reciprocating motion to each other said conveyor and said bank of nozzles to cause the insertion of the nozzles inside groups of said containers at a second operating position. 4. System according to claim 3, wherein said conveyor comprises a belt that is movable in step mode around corresponding pulleys and is provided with grasping grippers for grasping the containers; grasping one of said groups of containers from said conveying plane by said grippers in the first operating position being achieved simultaneously and during said inserting of said nozzles inside containers of a successive group of containers into said second operating position. 5. System according to claim 1, wherein said sterilising/depyrogenating unit comprises at least two sterilising/depyrogenating modules which are actuatable independently of one another according to hot and/or cold sterilising modes of the containers. 6. System according to claim 5, wherein said two sterilising/depyrogenating modules are substantially identical to each other. 7. System according to claim 5, wherein each of said sterilising/depyrogenating modules comprises a heating device, suitable for heating an air flow intended for being blown towards said containers inside a sterilising chamber to take said containers to a preset sterilising and depyrogenating temperature; a generating device of said air flow suitable for generating and conveying the same flow to said containers along a heating path crossing said heating device; a filtering element suitable for filtering said air flow up to a preset degree of purity; flow-switching members arranged along said air flow and switchable to define said heating path. 8. System according to claim 7, wherein said flow-switching members comprise at least a pair of butterfly switches switchable in push-pull mode between the respective open/closed positions. 9. System according to claim 7, wherein each of said sterilising/depyrogenating modules comprises an evacuation fan suitable for conveying part of said air flow to the external environment; a corresponding mixing valve being associated with said evacuation fan. 10. System according to claim 5, wherein each of said sterilising/depyrogenating modules comprises a refrigerating device, suitable for refrigerating an air flow intended for being blown towards said containers inside a sterilising chamber to take said containers to a preset sterilising and depyrogenating temperature; a generating device of said air flow, suitable for generating and conveying the same flow to said containers along a cooling path crossing said refrigerating device; a filtering element suitable for filtering said air flow up to a preset degree of purity; flow-switching members arranged along said air flow and switchable to define said cooling path. 11. System according to claim 10, wherein said flow-switching members comprise at least a pair of butterfly switches switchable in push-pull mode between the respective open/closed positions. 12. System according to claim 10, wherein each of said sterilising/depyrogenating module comprises an evacuation fan suitable for conveying part of said air flow to the external environment; a corresponding mixing valve being associated with said evacuation fan. 13. Compact system for packaging liquid products in a sterile environment, in particular pharmaceutical liquids injectable into suitable containers, the system comprising a plurality of operative packaging stations connected together and arranged in succession along an advancing path of said containers; said plurality of stations comprising at least a washing station intended for cleaning and decontaminating each of the said containers, at least a sterilising station for sterilising the containers exiting said washing station, and at least a filling and sealing station for filling said containers with said liquids and for sealing the containers; wherein said stations and a connecting arrangement thereof are mounted in an operating configuration on a sole work platform; said washing station and said sterilising station being arranged parallel to one another and placed alongside and connected together by a first conveyor of the containers arranged transversely to the washing station and the sterilising station to define a first substantially "U"-shaped portion of said path; said filling and sealing station being arranged aligned on said washing station and connected, in a staggered position, to said sterilising station by a second conveyor of said containers arranged transversely to the sterilising station to define a second substantially "L" shaped portion of said advancing path; wherein the system further comprises a sterile chamber, that extends above, by covering it, the portion of the system arranged downstream of said sterilising station along said "L"-shaped portion of said advancing path, and that said portion comprises said second conveyor and said filling and sealing station. 14. Compact system for packaging liquid products in a sterile environment, in particular pharmaceutical liquids injectable into suitable containers, the system comprising a plurality of operative packaging stations connected together and arranged in succession along an advancing path of said containers; said plurality of stations comprising at least a washing station intended for cleaning and decontaminating each of the said containers, at least a sterilising station for sterilising the containers exiting said washing station, and at least a filling and sealing station for filling said containers with said liquids and for sealing the containers; wherein said stations and a connecting arrangement thereof are mounted in an operating configuration on a sole work platform; said washing station and said sterilising station being arranged parallel to one another and placed alongside and connected together by a first conveyor of the containers arranged transversely to the washing station and the sterilising station to define a first substantially "U"-shaped portion of said path; said filling and sealing station being arranged aligned on said washing station and connected, in a staggered position, to said sterilising station by a second conveyor of said containers arranged transversely to the sterilising station to define a second substantially "L" shaped portion of said advancing path; wherein said filling and sealing station substantially comprises at least a filling unit having at least a bank of filling nozzles, at least a supplying and applying device of closing caps arranged along a filling line defined between two star conveyors; the station also being provided with weighing devices for weighing said containers and with a locking unit for locking the containers. 15. Compact system for packaging liquid products in a sterile environment, in particular pharmaceutical liquids injectable into suitable containers, the system comprising a plurality of operative packaging stations connected together and arranged in succession along an advancing path of said containers; said plurality of stations comprising at least a washing station intended for cleaning and decontaminating each of the said containers, at least a sterilising station for sterilising the containers exiting said washing station, and at least a filling and sealing station for filling said containers with said liquids and for sealing the containers; wherein said stations and a connecting arrangement thereof are mounted in an operating configuration on a sole work platform; wherein said sterilising station comprises a two-stage sterilising/depyrogenating unit; said two-stage sterilising/depyrogenating unit being enclosed inside an insulated covering structure. 16. Compact system for packaging liquid products in a sterile environment, in particular pharmaceutical liquids injectable into suitable containers, the system comprising a plurality of operative packaging stations connected together and arranged in succession along an advancing path of said containers; said plurality of stations comprising at least a washing station intended for cleaning and decontaminating each of the said containers, at least a sterilising station for sterilising the containers exiting said washing station, and at least a filling and sealing station for filling said containers with said liquids and for sealing the containers; wherein said stations and a connecting arrangement thereof are mounted in an operating configuration on a sole work platform; said filling and sealing station being connected to said sterilising station by a conveyor of said containers arranged transversely to said sterilising station; the system further comprising a sterile chamber, that extends above, by covering it, a portion of said system arranged downstream of said sterilising station, said portion comprising said conveyor and said filling and sealing station. 17. Compact system for packaging liquid products in a sterile environment, in particular pharmaceutical liquids injectable into suitable containers, the system comprising a plurality of operative packaging stations connected together and arranged in succession along an advancing path of said containers; said plurality of stations comprising at least a washing station intended for cleaning and decontaminating each of the said containers, at least a sterilising station for sterilising the containers exiting said washing station, and at least a filling and sealing station for filling said containers with said liquids and for sealing the containers; wherein said stations and a connecting arrangement thereof are mounted in an operating configuration on a sole work platform; said filling and sealing station substantially comprising at least a filling unit having at least a bank of filling nozzles, at least a supplying and applying device of closing caps arranged along a filling line defined between two star conveyors; the station also being provided with weighing devices for weighing said containers and with a locking unit for locking the containers.
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이 특허에 인용된 특허 (18)
Thomas D. Taggart, Apparatus and method for providing sterilization zones in an aseptic packaging sterilization tunnel.
Duffey Craig L. (Galena OH) Estadt Charles A. (Groveport OH) Gerdeman Roger J. (Columbus OH), Method and apparatus for automatically filling and sterilizing containers.
Andersson Jan (Ystad SEX) Martensson Lars (MalmSEX) Bjerborn Thomas (Lund SEX) Smith Gran (Lund SEX), Method of producing a gaseous hydrogen peroxide-containing sterilization fluid.
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