Stabilizers for polymerizable biocompatible materials
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-024/06
A61L-024/00
A61L-024/04
A61K-006/08
A61K-006/02
A61K-006/083
출원번호
UP-0734453
(2007-04-12)
등록번호
US-7589133
(2009-09-24)
발명자
/ 주소
Pomrink, Gregory J.
출원인 / 주소
Orthovita, INc.
대리인 / 주소
Woodcock Washburn LLP
인용정보
피인용 횟수 :
7인용 특허 :
15
초록
The present invention provides polymerizable biocompatible materials stabilized by amino acids or reducing salts to improve shelf life. Methods of stabilizing a polymerizable biocompatible material that inhibit auto polymerization of the material over time are also provided.
대표청구항▼
What is claimed: 1. A sterile, free radical polymerizable biocompatible material for orthopedic applications comprising at least one monomer having an acrylate functional group, at least one filler, and a stabilizer, wherein the stabilizer is cysteine and is present in an amount of 0.3%-1% by weigh
What is claimed: 1. A sterile, free radical polymerizable biocompatible material for orthopedic applications comprising at least one monomer having an acrylate functional group, at least one filler, and a stabilizer, wherein the stabilizer is cysteine and is present in an amount of 0.3%-1% by weight of the polymerizable biocompatible material. 2. The polymerizable biocompatible material of claim 1 wherein the amino acid is L-cysteine. 3. The polymerizable biocompatible material of claim 1 wherein said monomer is bisphenol-A-diglycidyl methacrylate, triethyleneglycol dimethacrylate, diurethane dimethacrylate, bisphenol-A-ethoxy methacrylate, methylmethacrylate, or methacrylate. 4. The polymerizable biocompatible material of claim 1 wherein said filler is comprised of particles ranging from about 0.01 μm to 2-3 mm. 5. The polymerizable biocompatible material of claim 4 wherein said particles range from about 0.1 to 100 μm. 6. The polymerizable biocompatible material of claim 4 wherein said filler is bioactive. 7. The polymerizable biocompatible material of claim 1 further comprising a polymerization inhibitor, wherein said inhibitor is hydroquinone or a functional equivalent. 8. The polymerizable biocompatible material of claim 7 wherein said polymerization inhibitor, is butylatedhydroxytoluene, butylated hydroxyaniline, UV-9 (2hydroxy-4-methoxy benzophenone), methyl ether hydroquinone, 4-benzyloxy phenol, or 3,5-diisopropyl phenol. 9. The polymerizable biocompatible material of claim 8 wherein the polymerization inhibitor is butylatedhydroxytoluene. 10. The polymerizable biocompatible material of claim 1 wherein the material forms a liquid/powder or paste/paste system. 11. The polymerizable biocompatible material of claim 1 wherein the filler is barium glass, barium-boroaluminosilicate glass, sodium borosilicate, silica, 45S5 glass, bioactive glass ceramics, glass-ceramics, bioactive synthetic combeite glass-ceramic, e-glass, s-glass, iron phosphate, or combinations thereof. 12. A method of stabilizing a free radical polymerizable biocompatible material comprising: providing at least one monomer having an acrylate functional group, adding cysteine in an amount of 0.3%-1% by weight of the polymerizable biocompatible material to said monomer to form a pre-polymerization stabilizing mix, and adding a filler to said mix to form a stabilized paste. 13. The method of claim 12 wherein said monomer is bisphenol-A-diglycidyl methacrylate, triethyleneglycol dimethacrylate, diurethane dimethacrylate, bisphenol-A-ethoxy methacrylate, methylmethacrylate, or methacrylate. 14. The method of claim 12 wherein said filler is comprised of particles ranging from about 0.01 μm to 2-3 mm. 15. The method of claim 12 wherein said particles range from about 0.1 to 100 μm. 16. The method of claim 12 wherein said filler is bioactive. 17. The method of claim 12 further comprising at least one polymerization inhibitor. 18. The method of claim 12, wherein said polymerization inhibitor is hydroquinone or various functional equivalents. 19. The method of claim 18 wherein said functional equivalents are butylatedhydroxytoluene, butylated hydroxyaniline, UV-9 (2-hydroxy-4-methoxy benzophenone), methyl ether hydroquinone, 4-benzyloxy phenol, or 3,5-diisopropyl phenol. 20. The method of claim 17 wherein the polymerization inhibitor is butylatedhydroxytoluene. 21. The method of claim 12 wherein the filler is barium glass, barium-boroaluminosilicate glass, sodium borosilicate, silica, 45S5 glass, bioactive glass ceramics, glass-ceramics, bioactive synthetic combeite glass-ceramic, e-glass, s-glass, iron phosphate, or combinations thereof.
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