IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0908584
(2005-05-18)
|
등록번호 |
US-7591806
(2009-10-20)
|
발명자
/ 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
16 인용 특허 :
28 |
초록
▼
High-aspect-ratio microdevices comprising microneedles, microknives and microblades and their manufacturing methods are disclosed. These devices can be used for the delivery of therapeutic agents across the skin or other tissue barriers to allow chemical and biological molecules getting into the ci
High-aspect-ratio microdevices comprising microneedles, microknives and microblades and their manufacturing methods are disclosed. These devices can be used for the delivery of therapeutic agents across the skin or other tissue barriers to allow chemical and biological molecules getting into the circulation systems. The microneedles can also be used to withdraw body fluids for analysis of clinically relevant species when the device has an integrated body fluid sensor or sensor array in the vicinity of microneedles.
대표청구항
▼
What is claimed is: 1. A method of making a microfabricated device for delivery of an active agent comprising: performing a first isotropic etch to define microneedle tips, microblade edge, or microknife edge of the device, performing a second anisotropic Bosch etch to define microneedle shaft, mic
What is claimed is: 1. A method of making a microfabricated device for delivery of an active agent comprising: performing a first isotropic etch to define microneedle tips, microblade edge, or microknife edge of the device, performing a second anisotropic Bosch etch to define microneedle shaft, microblade body, or microknife body of the device, thereby forming the device, and forming the device, wherein the microfabricated device comprises a structure formed of a material selected from the group consisting of metals, ceramics, silicon, glass, polymers, and combinations thereof, wherein the structure is selected from the group consisting of solid microneedles, solid microblades, solid microknives, and a combination thereof, wherein the microneedles, microblades, or microknives have and aspect ration of about 10:1 or higher. 2. A method of making a microfabricated device for delivery of an active agent comprising: performing an anisotropic etch first to define the body of microneedle, microblade or microknife device, and performing orientation dependent etch of Si using potassium hydroxide or tetramethyl ammonium hydroxide or sodium hydroxide solution, thereby forming the device, wherein the microfabricated device comprises a structure formed of a material selected from the group consisting of metals, ceramics, silicon, glass, polymers, and combinations thereof, wherein the structure is selected from the group consisting of solid microneedles, solid microblades, solid microknives, and a combination thereof, wherein the microneedles, microblades, or microknives have and aspect ration of about 10:1 or higher. 3. A method of making a microfabricated device for delivery of an active agent comprising moving one or two electrodes comprising a working electrode which is a cathode and a counter electrode which is an anode during an electrochemical etch to define the body of the microneedle, microblade, or microknife of the device, and forming the device, wherein the microfabricated device comprises a structure formed of a material selected from the group consisting of metals, ceramics, silicon, glass, polymers, and combinations thereof, wherein the structure is selected from the group consisting of solid microneedles, solid microblades, solid microknives, and a combination thereof, wherein the microneedles, microblades, or microknives have and aspect ration of about 10:1 or higher. 4. A microfabricated device for delivery of an active agent produced by a process comprising: performing a first isotropic etch to define microneedle tips, microblade edge, or microknife edge, performing a second anisotropic Bosch etch to define microneedle shaft, microblade body, or microknife body, thereby forming the device, and forming the microfabricated device, wherein the microfabricated device comprises a structure formed of a material selected from the group consisting of metals, ceramics, silicon, glass, polymers, and combinations thereof, wherein the structure is selected from the group consisting of solid microneedles, solid microblades, solid microknives, and a combination thereof, wherein the microneedles, microblades, or microknives have and aspect ration of about 10:1 or higher. 5. A microfabricated device for delivery of an active agent produced by a process comprising: performing an anisotropic etch first to define the body of a microneedle, microblade, or microknife, and performing orientation dependent etch of Si using potassium hydroxide or tetramethyl ammonium hydroxide or sodium hydroxide solution, thereby forming the microfabricated device, wherein the microfabricated device comprises a structure formed of a material selected from the group consisting of metals, ceramics, silicon, glass, polymers, and combinations thereof, wherein the structure is selected from the group consisting of solid microneedles, solid microblades, solid microknives, and a combination thereof, wherein the microneedles, microblades, or microknives have and aspect ration of about 10:1 or higher. 6. A microfabricated device for delivery of an active agent produced by a process comprising: moving one or two electrodes comprising a working electrode which is a cathode and a counter electrode which is a patterned anode during electrochemical etch, and forming the microfabricated device, wherein the microfabricated device comprises a structure formed of a material selected from the group consisting of metals, ceramics, silicon, glass, polymers, and combinations thereof, wherein the structure is selected from the group consisting of solid microneedles, solid microblades, solid microknives, and a combination thereof, wherein the microneedles, microblades, or microknives have and aspect ration of about 10:1 or higher.
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