Pyrimidine compounds as serotonin receptor modulators
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/519
C07D-071/04
C07D-071/00
C07D-087/04
C07D-087/00
C07D-091/04
C07D-091/00
C07D-039/28
C07D-039/00
C07D-039/72
C07D-039/42
C07D-087/08
C07D-001/04
C07D-001/00
C07D-003/04
C07D-003/00
C07D-013/04
C07D-013/00
C07D-017/04
C07D-017/00
C07D-019/04
C07D-019/00
출원번호
UP-0460294
(2006-07-27)
등록번호
US-7598255
(2009-10-20)
발명자
/ 주소
Dvorak, Curt A.
출원인 / 주소
Janssen Pharmaceutica NV
대리인 / 주소
Atkins, Michael J.
인용정보
피인용 횟수 :
6인용 특허 :
16
초록
Certain pyrimidine-containing compounds are serotonin receptor modulators useful in the treatment of serotonin-mediated diseases.
대표청구항▼
What is claimed is: 1. A compound that is 4-(4-fluoro-phenyl)-2-isopropyl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidine or a pharmaceutically acceptable salt thereof. 2. A compound of claim 1 isotopically-labelled to be detectable by PET or SPECT. 3. The compound of claim 1 wherein said pharmaceut
What is claimed is: 1. A compound that is 4-(4-fluoro-phenyl)-2-isopropyl-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidine or a pharmaceutically acceptable salt thereof. 2. A compound of claim 1 isotopically-labelled to be detectable by PET or SPECT. 3. The compound of claim 1 wherein said pharmaceutically acceptable salt is selected from the group consisting of hydrobromide, hydrochloride, sulfate, bisulfate, nitrate, acetate, oxalate, valerate, oleate, palmitate, stearate, laurate, borate, benzoate, lactate, phosphate, tosylate, citrate, maleate, fumarate, succinate, tartrate, naphthylate, mesylate, glucoheptonate, lactiobionate, and laurylsulfonate. 4. The compound of claim 3 wherein said pharmaceutically acceptable salt is hydrochloride. 5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound that is 4-(4-fluoro-phenyl)-2-isopropyl-5,6,7,8-tetrahydro-pyrido [4,3-d]pyrimidine or a pharmaceutically acceptable salt thereof. 6. The composition of claim 5 wherein said pharmaceutically acceptable salt is selected from the group consisting of hydrobromide, hydrochloride, sulfate, bisulfate, nitrate, acetate, oxalate, valerate, oleate, palmitate, stearate, laurate, borate, benzoate, lactate, phosphate, tosylate, citrate, maleate, fumarate, succinate, tartrate, naphthylate, mesylate, glucoheptonate, lactiobionate, and laurylsulfonate. 7. The composition of claim 6 wherein said pharmaceutically acceptable salt is hydrochloride. 8. The compound of claim 3 wherein said pharmaceutically acceptable salt is citrate. 9. The composition of claim 6 wherein said pharmaceutically acceptable salt is citrate. 10. A compound which is a citric acid salt of 4-(4-fluoro-phenyl)-2-isopropyl-5,6,7,8-tetrahydro-pyrido [4,3-d]pyrimidine. 11. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound that is a citric acid salt of 4-(4-fluoro-phenyl)-2-isopropyl-5,6,7,8-tetrahydro-pyrido [4,3-d]pyrimidine.
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이 특허에 인용된 특허 (16)
Christensen Jorgen Anders (Virum DK) Squires Richard Felt (Gl. Olstykke DK), 4-Phenylpiperidine compounds.
Welch, Jr., Willard M.; Harbert, Charles A.; Koe, B. Kenneth; Kraska, Allen R., Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine.
Stephens Sally I. (Mountain View CA) Hamel Lawrence G. (Sunnyvale CA) Barclay Glen E. (Sunnyvale CA) Wong Patrick S. L. (Hayward CA), Chlorpheniramine therapy.
Guittard George V. (Cupertino CA) Deters Joseph C. (Mountain View CA) Theeuwes Felix (Los Altos CA) Cortese Richard (San Jose CA), Osmotic system with instant drug availability.
Guittard George V. (Cupertino CA) Deters Joseph C. (Mountain View CA) Theeuwes Felix (Los Altos CA) Cortese Richard (San Jose CA), Osmotic system with instant drug availability.
Sanfilippo Pauline J. (Chester Springs PA) Bonner Mary P. (Warrington PA) McNally James J. (Souderton PA), Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful as platelet aggregation inhibitors.
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