IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0512028
(2003-04-24)
|
등록번호 |
US-7604936
(2009-11-10)
|
국제출원번호 |
PCT/US03/013015
(2003-04-24)
|
§371/§102 date |
20050721
(20050721)
|
국제공개번호 |
WO03/090694
(2003-11-06)
|
발명자
/ 주소 |
- Wohlgemuth, Jay
- Fry, Kirk E.
- Woodward, Robert
- Ly, Ngoc
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
1 인용 특허 :
164 |
초록
▼
Methods of diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monito
Methods of diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.
대표청구항
▼
We claim: 1. A method of diagnosing or monitoring an autoimmune or chronic inflammatory disease in a patient, comprising detecting the expression level of a gene in said patient to diagnose or monitor said auto immune or chronic inflammatory disease in said patient wherein said gene comprises the n
We claim: 1. A method of diagnosing or monitoring an autoimmune or chronic inflammatory disease in a patient, comprising detecting the expression level of a gene in said patient to diagnose or monitor said auto immune or chronic inflammatory disease in said patient wherein said gene comprises the nucleotide sequence of SEQ ID NO:739. 2. The method of claim 1, wherein said auto immune or chronic inflammatory disease is selected from the group consisting of: Rheumatoid Arthritis, Cholecystitis, Systemic Lupus Erythematosis, Sjogrens Disease, CREST syndrome, Scleroderma, Ankylosing Spondylitis, Crohn's, Ulcerative Colitis, Primary Sclerosing Cholangitis, Appendicitis, Diverticulitis, Primary Biliary Sclerosis, Wegener's Granulomatosis, Polyarteritis nodosa, Whipple's Disease, Psoriasis, Microscopic Polyanngiitis, Takayasu's Disease, Kawasaki's Disease, Autoimmune hepatitis, Asthma, Churg-Strauss Disease, Beurger's Disease, Raynaud's Disease, and Cholecystitis. 3. The method of claim 1 wherein said disease is Systemic Lupus Erythematosis. 4. The method of claim 1 wherein said disease is Rheumatoid Arthritis. 5. The method of claim 1 wherein said expression level is detected by measuring the RNA level expressed by said gene. 6. The method of claim 5, further including isolating RNA from said patient prior to detecting said RNA level expressed by said gene. 7. The method of claim 6 wherein said RNA level is detected by PCR. 8. The method of claim 6 wherein said RNA level is detected by hybridization. 9. The method of claim 6 wherein said RNA level is detected by hybridization to an oligonucleotide. 10. The method of claim 9 wherein said oligonucleotide comprises DNA, RNA, cDNA, PNA, genomic DNA, or synthetic oligonucleotides. 11. The method of claim 1, wherein said expression level detected is expression level in the patient's bodily fluid. 12. The method of claim 11, wherein said bodily fluid is peripheral blood.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.