Methods for uniform metal impregnation into a nanoporous material
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B05D-001/18
출원번호
UP-0436489
(2006-05-18)
등록번호
US-7608305
(2009-11-10)
발명자
/ 주소
Chan, Selena
Kwon, Sunghoon
Sundararajan, Narayan
출원인 / 주소
Intel Corporation
대리인 / 주소
Pillsbury Winthrop Shaw Pittman LLP
인용정보
피인용 횟수 :
7인용 특허 :
53
초록▼
The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210. Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of me
The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210. Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.
대표청구항▼
What is claimed is: 1. A method comprising: a) obtaining a porous membrane; b) inserting the porous membrane into a microfluidic pathway between a solvent reservoir and a waste reservoir connected through cross-paths, wherein the porous membrane is placed between the cross-paths; c) introducing a m
What is claimed is: 1. A method comprising: a) obtaining a porous membrane; b) inserting the porous membrane into a microfluidic pathway between a solvent reservoir and a waste reservoir connected through cross-paths, wherein the porous membrane is placed between the cross-paths; c) introducing a metal salt solution into the porous membrane to form a metal coated porous membrane; and d) incorporating the metal-coated porous membrane in a system for analysis and/or separation of polymer molecules. 2. The method of claim 1, wherein the porous membrane is a porous silicon membrane, a porous polysilicon membrane, a porous aluminum membrane, a porous alumina membrane or a porous metal grid. 3. The method of claim 1, wherein the porous membrane is a porous silicon membrane. 4. The method of claim 1, further comprising electropolishing the porous membrane. 5. The method of claim 1, wherein two or more different metal salt solutions are introduced into the porous membrane. 6. The method of claim 1, wherein the metal-coated porous membrane comprises at least one Raman active metal selected from the group consisting of silver, gold, platinum, copper and aluminum. 7. The method of claim 1, further comprising incorporating the metal-coated porous membrane in a Raman detection system. 8. The method of claim 7, further comprising introducing a sample comprising a target molecule into the metal-coated porous membrane, exciting the target molecule with an excitatory light, and detecting a Raman signal by a Raman detector. 9. The method of claim 8, further comprising removing the sample from the metal-coated porous membrane. 10. The method of claim 8, wherein the method is configured to detect a single molecule. 11. The method of claim 10, wherein the single molecule is a single molecule of a nucleotide. 12. The method of claim 8, further comprising introducing a chemical enhancer to enhance the Raman signal.
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