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Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/355
  • A61K-031/352
  • C07D-011/24
  • C07D-011/00
  • C07D-011/72
출원번호 UP-0876612 (2007-10-22)
등록번호 US-7608638 (2009-11-10)
발명자 / 주소
  • Sanders, Bob G.
  • Kline, Kimberly
  • Hurley, Daurence
  • Gardner, Robb
  • Menchaca, Marla
  • Yu, Weiping
  • Ramanan, Puthucode N.
  • Liu, Shenquan
  • Israel, Karen
출원인 / 주소
  • Research Development Foundation
대리인 / 주소
    Fulbright & Jaworski LLP
인용정보 피인용 횟수 : 0  인용 특허 : 35

초록

The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein when Y is oxygen or nitrogen, n is 1 and when Y is sulfur, n is 0. Also provided is a

대표청구항

What is claimed is: 1. A compound of the formula: wherein: R1 is hydroxy or methoxy; R2 and R3 are independently hydrogen or methyl. 2. The compound of claim 1, wherein R1 is hydroxy. 3. The compound of claim 1, wherein R1 is methoxy. 4. The compound of claim 1, wherein R2 is hydrogen.

이 특허에 인용된 특허 (35)

  1. Lee Sijoon,KRX ; Cheong Heui-young,KRX, Alpha-tocopherol cyclopropylates, the new vitamin E derivatives and method for producing the same.
  2. Beard Richard L. ; Jeon Raok ; Colon Diana F. ; Chandraratna Roshantha A., Amines substituted with a tetrahydroquinolinyl group an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity.
  3. Komatsu Yasuhiro (c/o Nisshin Flour Milling Co. ; Ltd. Central Research Institute ; 177-3 Ohaza-Tsurugaoka ; Ohi-machi ; Iruma-gun ; Saitama-ken JPX) Nagai Michiko (c/o Nisshin Flour Milling Co. ; Lt, Antitumor agent.
  4. Le Baut Guillaume (Saint Sebastien Sur Loire FRX) Babingui Jean-Paul (Nantes FRX) Courant Jacqueline (Nantes FRX) Robert Jean-Michel (Nantes FRX) Renard Pierre (Versailles FRX) Caignard Daniel-Henri , Benzopyran compounds.
  5. Le Baut Guillaume (Saint Sebastien Sur Loire FRX) Babingui Jean-Paul (Nantes FRX) Robert-Piessard Sylvie (Nantes FRX) Renard Pierre (Versailles FRX) Caignard Daniel-henri (Paris FRX) Renaud de la Fav, Benzopyran compounds.
  6. Robinson Keith M. (Glendale OH) Heineke Eric W. (Cincinnati OH), Cholesterol-lowering tocopherol analogs.
  7. Walser Armin (West Caldwell NJ), Chromanes and their pharmaceutical compositions and methods.
  8. Wirth Ronald P. (Minneapolis MN), Diester derivatives of tocopherol.
  9. Holick Michael F. (Sudbury MA) Holick Sally A. (Sudbury MA), Glycosides of vitamins A, E and K.
  10. Grisar J. Martin (Wissembourg FRX) Petty Margaret A. (Strasbourg FRX) Bolkenius Frank (Kehl DEX), Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans.
  11. Della Valle Francesco (Padova ITX) Lorenzi Silvana (Padova ITX) Marcolongo Gabriele (Carrara S. Giorgio ITX), Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with p.
  12. Tazawa Masashi,JPX ; Suzuki Maki,JPX, Image input apparatus.
  13. Fariss Marc W. (Manakin-Sabot VA), Ionizable congeners of aromatic and aliphatic alcohols as anti-leukemia agents.
  14. Mayhew Eric (South Wales NY) Ehrke M. Jane (Lancaster NY) Mace Kenneth (Buffalo NY) Szoka Francis (San Francisco CA) Olson Fred C. (Helena MT), Liposome drug delivery method and composition.
  15. Radhakrishnan Ramachandran (Fremont CA) Mihalko Paul J. (Fremont CA) Abra Robert M. (San Francisco CA), Method and apparatus for administering dehydrated liposomes by inhalation.
  16. Voorhees John J. (Ann Arbor MI) Hammarstrom Sven R. (Djursholm SEX) Hamberg Mats A. (Lidingo SEX) Samuelsson Bengt I. (Danderyd SEX), Method for alleviating psoriasis.
  17. Fariss Marc W. (Manakin-Sabot VA), Method for protecting animals against tacrine induced cytotoxic injury using sterol compounds.
  18. Elson Charles E., Method of suppressing tumor growth with combinations of isoprenoids and statins.
  19. Bennet Justin D. (4803 Hart Dr. San Diego CA 92116), Method of treating ulcerative colitis.
  20. Gehrken Henning-Peter (Lambsheim DEX) Ernst Hansgeorg (Ludwigshafen DEX) Paust Joachim (Neuhofen DEX), Novel optically active chroman derivatives, their preparation and novel intermediates.
  21. Makishima Makoto,JPX ; Kanatani Yasuhiro,JPX ; Honma Yoshio,JPX ; Inomata Kohei,JPX ; Kishiye Takao,JPX, Pharmaceutical composition for the treatment of leukemia containing 9-cis-retinoic acid-.alpha.-tocopherol ester.
  22. Yazdi Parvin T. ; Pruss Thaddeus P., Pharmaceutical compositions, novel uses, and novel form of .alpha.-tocopherylphosphocholine.
  23. Rosenau Thomas,DEX ; Habicher Wolf-Dieter,DEX, Preparation of chromanyl derivatives.
  24. Temple Chester S. ; Parrinello Luciano M., Substrates coated with antioxidant compositions and method for inhibiting the oxidation of such compositions applied to.
  25. Malfroy-Camine Bernard (Arlington MA) Baudry Michel (Long Beach CA), Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease.
  26. Ogata Kazumi (Toyonaka JPX) Sakaue Takahiro (Itami JPX) Ogino Shinya (Itami JPX) Matsuura Sachiko (Osaka JPX) Nagao Rie (Neyagawa JPX), Therapeutic composition for pancreatitis.
  27. Sanders,Bob G.; Kline,Kimberly; Yu,Weiping; Liu,Hui; Hantash,Feras, Tocopherol associated protein and uses thereof.
  28. Hendler Sheldon S. (La Jolla CA) Sanchez Robert (Carlsbad CA), Tocopherol-based antiviral agents and method of using same.
  29. Sanders, Bob G.; Kline, Kimberly; Hurley, Laurence; Gardner, Robb; Menchaca, Marla; Yu, Weiping; Ramanan, Puthucode N.; Liu, Shenquan; Israel, Karen, Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof.
  30. Sanders, Bob G.; Kline, Kimberly; Hurley, Laurence; Gardner, Robb; Menchaca, Marla; Yu, Weiping; Ramanan, Puthucode N.; Liu, Shenquan; Israel, Karen, Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof.
  31. Sanders,Bob G.; Kline,Kimberly; Hurley,Laurence; Gardner,Robb; Menchaca,Marla; Yu,Weiping; Ramanan,Puthucode N.; Liu,Shenquan; Israel,Karen, Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof.
  32. Sanders,Bob G.; Kline,Kimberly; Yu,Weiping, Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof.
  33. Bob G. Sanders ; Kimberly Kline ; Laurence Hurley ; Robb Gardner ; Marla Menchaca ; Weiping Yu ; Puthucode N. Ramanan ; Shenquan Liu ; Karen Israel, Tocopherols, tocotrienols, other chroman and side chain derivatives and uses therof.
  34. Schneider Gunther,DEX ; Thiem Joachim,DEX ; Lahmann Martina,DEX, Tocopheryl glycosides, their preparation, and their use as surfactants, as antioxidants and as the active substance prev.
  35. Lane Ronald H. ; Qureshi Asaf A. ; Salser Winston A., Tocotrienols and tocotrienol-like compounds and methods for their use.
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