IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0555413
(2006-11-01)
|
등록번호 |
US-7611542
(2009-11-16)
|
발명자
/ 주소 |
- Bourne, George
- Buiser, Marcia S.
- Casey, II, Thomas V.
- Keenan, Steve
- Lanphere, Janel L.
- Li, Jianmin
- McKenna, Erin P.
- Minasian, Zarouhi
- Rao, Doreen
|
출원인 / 주소 |
- Boston Scientific SciMed, Inc.
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
14 인용 특허 :
305 |
초록
A method of treating tissue includes placing substantially spherical polymer particles in the tissue. The particles include an interior region having relatively large pores and a first region substantially surrounding the interior having fewer relatively large pores than the interior region.
대표청구항
▼
What is claimed is: 1. A method of treating tissue, the method comprising: placing substantially spherical polymer particles in the tissue, the particles having an interior region comprising pores having a predominant pore size in the range of about 20 to 35 microns, a first region substantially su
What is claimed is: 1. A method of treating tissue, the method comprising: placing substantially spherical polymer particles in the tissue, the particles having an interior region comprising pores having a predominant pore size in the range of about 20 to 35 microns, a first region substantially surrounding the interior region comprising pores having a predominant pore size in the range of about 2 to 18 microns, and a third region surrounding the second region comprising pores having a predominant pore size of about 2 microns or less, wherein the polymer comprises crosslinked polyvinyl alcohol. 2. The method of claim 1, wherein the particles are injected into the tissue. 3. The method of claim 2, wherein the particles are injected percutaneously. 4. The method of claim 1, wherein the particles are delivered through a catheter. 5. The method of claim 1, comprising forming a cavity in the tissue, and placing the particles in the cavity. 6. The method of claim 1, wherein the tissue is adjacent to a body passageway. 7. The method of claim 6, wherein the passageway is defined by a ureter. 8. The method of claim 1, wherein the tissue is adjacent to a body passageway, the particles being placed in an amount effective to narrow the passageway. 9. The method of claim 1, wherein the polyvinyl alcohol is 1,3 diol acetalized. 10. The method of claim 1, wherein the particles comprise a polysaccharide. 11. The method of claim 1, wherein the polysaccharide comprises alginate. 12. The method of claim 1, wherein the particles comprise a therapeutic agent. 13. A method of treating an individual, the method comprising: placing a therapeutically effective amount of substantially spherical particles comprising polyvinyl alcohol in a tissue of the individual, the particles having an interior region comprising pores having a predominant pore size in the range of about 20 to 35 microns, a first region substantially surrounding the interior region comprising pores having a predominant pore size in the range of about 2 to 18 microns, and a third region surrounding the second region comprising pores having a predominant pore size of about 2 microns or less, wherein the polymer comprises crosslinked polyvinyl alcohol. 14. The method of claim 13, further comprising selecting the individual diagnosed with gastroesophageal reflux disease. 15. The method of claim 14, wherein the tissue is adjacent to a gastrointestinal tract. 16. The method of claim 13, further comprising selecting the individual diagnosed with vesicoureteral reflux. 17. The method of claim 16, wherein the tissue is adjacent to a ureter. 18. The method of claim 13, further comprising selecting the individual diagnosed with urinary incontinence. 19. The method of claim 13, further comprising selecting the individual diagnosed with fecal incontinence. 20. The method of claim 13, wherein the particles are placed percutaneously. 21. The method of claim 13, wherein the particles are placed through a catheter. 22. The method of claim 13, further comprising selecting the individual diagnosed with instrinsic sphincteric deficiency. 23. The method of claim 13, further comprising selecting the individual diagnosed with vocal cord paralysis. 24. The method of claim 13, further comprising selecting the individual in need of a reconstructive or cosmetic procedure. 25. The method of claim 1, wherein, for at least some of the plurality of particles, each particle has a different radius. 26. The method of claim 13, wherein, for at least some of the therapeutically effective amount of particles, each particle has a different radius.
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