IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0142542
(2005-06-01)
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등록번호 |
US-7618592
(2009-11-27)
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발명자
/ 주소 |
- Burnham, Richard T.
- Lane, Joseph P.
- Scott, Christopher A.
- Sheridan, Steven D.
- Shafner, Richard J.
|
출원인 / 주소 |
|
인용정보 |
피인용 횟수 :
1 인용 특허 :
11 |
초록
▼
A plate liner detachably engageable onto a microarray plate (or underdrain plate component thereof), suited for preventing or confining pendant drop formation. It is provided either as a stand-alone item, or--preferably--in kit form, within a sanitary package, together with other pre-matched microar
A plate liner detachably engageable onto a microarray plate (or underdrain plate component thereof), suited for preventing or confining pendant drop formation. It is provided either as a stand-alone item, or--preferably--in kit form, within a sanitary package, together with other pre-matched microarray filtration components.
대표청구항
▼
The invention claimed is: 1. A sterile microarray kit comprising, within packaging, the following: (a) a sample plate comprising an array of wells; (b) a drain plate comprising an array of underdrains, each underdrain comprising an upstream end and a downstream end, with a spout provided at said do
The invention claimed is: 1. A sterile microarray kit comprising, within packaging, the following: (a) a sample plate comprising an array of wells; (b) a drain plate comprising an array of underdrains, each underdrain comprising an upstream end and a downstream end, with a spout provided at said downstream end that enables fluid to flow out of said underdrain, and the drain plate being engaged onto said sample plate such that the array of underdrains are in register with said wells, and whereby fluid placed in said wells flow into said underdrains when the drain plate is engaged onto said sample plate; and (c) a single continuous plate liner comprising an array of hermetic spout isolators, the plate liner being detachably engaged or engageable manually onto said drain plate such that the hermetic spout isolators are in register with said underdrains, wherein a hermetic seal is formed at or around the underdrain spouts when the plate liner is engaged onto the drain plate, and wherein: (i) the flow of fluid placed in said wells and passing into said underdrains is hermetically blocked from flowing past the hermetic spout isolators when the plate liner is engaged onto said drain plate, wherein the hermetic spout isolators are capable of either prevention of pendant drop formation or containment of pendant drop formation is a pendant drop is formed, such that any appreciable amount of fluid placed in the wells is prevented from leaving the wells or the underdrains when the plate liner is engaged onto the drain plate, and if any fluid leaves the wells, the volume of such fluid is substantially less or negligible compared to the fluid volume of said wells, and (ii) the force required to disengage the plate liner from said drain plate is substantially less than the force required to disengage said drain plate from said sample plate. 2. The sterile microarray kit of claim 1, wherein said plate liner is detachably engaged or engageable onto said drain plate by means of individual friction-fitted couplings of said hermetic spout isolators with said spouts. 3. The sterile microarray kit of claim 1, wherein said plate liner is detachably engaged or engageable onto said drain plate by means of friction-fitted coupling of said plate liner onto the periphery of said drain plate; and. 4. The sterile microarray kit of claim 3, wherein: hermetic spout isolators are optically configured to enable automated optical interrogation of fluid captured therein. 5. A single continuous plate liner suited for controlling pendant drop formation in a specific pre-defined microarray, wherein said microarray comprises an array of wells in a sample plate and an array of underdrains in a drain plate, wherein each underdrain of said drain plate has an upstream end and a downstream end, with a spout provided at said downstream end that enables fluid to flow out of said underdrain and wherein said drain plate is engaged to a bottom surface of said sample plate, and wherein: (a) the plate liner engages detachably onto said microarray, such that the force required to manually disengage the plate liner from said microarray is substantially less than the force required to separate said sample plate from said drain plate; and (b) the plate liner comprises an array of hermetic spout isolators that are in register with said underdrains, and wherein a hermetic seal is formed at or around the underdrain spouts when the plate liner is engaged onto said specific pre-defined microarray, wherein the hermetic spot isolators are capable of either preventing pendant drop formation or containment of pendant drop formation, if a pendant drop is formed. 6. The plate liner of claim 5, wherein said detachable engagement of said plate liner onto said microarray is effected by means of individual friction-fitted couplings of said hermetic spout isolators with said spouts. 7. The plate liner of claim 5, wherein said detachable engagement of said plate liner onto said microarray is effected by means of friction-fitted coupling of said plate liner onto a periphery of the microarray. 8. The plate liner of claim 5, wherein the spout isolators are optically configured to enable automated optical interrogation of fluid captured therein. 9. The sterile microarray kit of claim 1, wherein: (a) said plate liner is detachably engaged or engageable onto said drain plate by means of friction-fitted coupling of said plate liner onto the periphery of said drain plate; (b) hermetic spout isolators are optically configured to enable automated optical interrogation of fluid captured therein; and (c) at least a web area of the plate liner between the hermetic spout isolators is formed of a light opaque material. 10. The sterile microarray kit of claim 1, wherein: (a) said plate liner is detachably engaged or engageable onto said drain plate by means of friction-fitted coupling of said plate liner onto the periphery of said drain plate; (b) the hermetic spout isolators are optically configured to enable automated optical interrogation of fluid captured therein; and (c) a web area of the plate liner between the hermetic spout isolators and sidewalls of the hermetic spout isolators are formed of a light opaque material. 11. The sterile microarray kit of claim 1 wherein the spout isolators are optically configured to enable automated optical interrogation of fluid captured therein. 12. The plate liner of claim 5, wherein said hermetic spout isolators are capable of hermetically capturing fluid drops expressed out of said spouts in a volume substantially less than the volume of said wells and are optically configured to enable automated optical interrogation of fluid captured therein. 13. The plate liner of claim 5, wherein said hermetic spout isolators are capable of hermetically capturing fluid drops expressed out of said spouts in a volume substantially less than the volume of said wells, are optically configured to enable automated optical interrogation of fluid captured therein and at least a web area between the isolators is formed of a light opaque material. 14. The plate liner of claim 5 wherein said hermetic spout isolators are capable of hermetically capturing fluid drops expressed out of said spouts in a volume substantially less than the volume of said wells, are optically configured to enable automated optical interrogation of fluid captured therein and a web area between the isolators and sidewalls of the isolators are formed of a light opaque material.
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