Biomimetic compounds and synthetic methods therefor
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08F-016/14
C08F-016/00
출원번호
UP-0834651
(2007-08-06)
등록번호
US-7622533
(2009-12-02)
발명자
/ 주소
Lee, Bruce P.
출원인 / 주소
Nerites Corporation
대리인 / 주소
Casimir Jones S.C.
인용정보
피인용 횟수 :
38인용 특허 :
92
초록▼
Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical
Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.
대표청구항▼
What is claimed is as follows: 1. A DHPD-modified linear polymer (DHPp) according to Formula (I): wherein LG is an optional linking group, DHPD is a dihydroxyphenyl derivative selected from 3,4-dihydroxyphenylalanine or 3,4-dihydroxyhydrocinnamic acid, and pB is a linear polymeric back bone. 2
What is claimed is as follows: 1. A DHPD-modified linear polymer (DHPp) according to Formula (I): wherein LG is an optional linking group, DHPD is a dihydroxyphenyl derivative selected from 3,4-dihydroxyphenylalanine or 3,4-dihydroxyhydrocinnamic acid, and pB is a linear polymeric back bone. 2. A polymer of claim 1 wherein the DHPD comprises at least about 1 to about 100 weight percent of the DHPp. 3. A polymer of claim 1 wherein the DHPD comprises at least about 2 to about 65 weight percent of DHPp. 4. A polymer of claim 1 wherein DHPD comprises about 3 to about 55 weight percent of DHPp. 5. A polymer of claim 1 wherein the pB consists essentially of polyalkylene oxide. 6. A polymer according to claim 1 wherein pB is substantially a homopolymer. 7. A DHPD-modified linear polymer DHPp according to Formula (II): wherein R1 is a monomer or prepolymer linked or polymerized to form a linear polymeric backbone (pB), DHPD is a dihydroxyphenyl derivative selected from 3,4-dihydroxyphenylalanine or 3,4-dihydroxyhydrocinnamic acid, and LG is an optional linking group. 8. A polymer according to claim 7 wherein R1 is selected from the group consisting of polyether, polyester, polyamide, polyacrylate, and polyalkyl. 9. A polymer according to claim 7 wherein R1 is linked through urethane, urea, amide, ester, carbonate, or carbon-carbon bond formation. 10. The polymer of claim 1, wherein the pB comprises a polyacrylate, a polymethacrylate, a polyacrylamide, a polymethacrylamide, a polyacrylate ester, a polymethacrylate ester, a polyvinylic or a polyallylic polymeric backbone. 11. A polymer of claim 10, wherein the DHPD comprises at least about 1 to about 100 weight percent of the DHPp. 12. A polymer of claim 10, wherein the DHPD comprises at least about 2 to about 65 weight percent of DHPp. 13. A polymer of claim 10, wherein DHPD comprises about 3 to about 55 weight percent of DHPp. 14. The polymer of claim 10, wherein the polyacrylate, polymethacrylate, polyacrylamide, polymethacrylamide, polyacrylate ester, polymethacrylate ester, polyvinylic or polyallylic polymeric backbone is selected from poly(ethylene glycol) methyl ether methacrylate, poly(ethylene glycol) methyl ether acrylamide, poly(ethylene glycol) methyl ether methacrylamide, acrylamide, N-acryloylmorpholine, 2-hydroxymethacrylate, N-isopropylacrylamide, 2-methoxyethyl acrylate, 3-methacryloylaminopropyldimethyl(3-sulfopropyl)ammonium hydroxide, vinylpyrrolidone, 3-acrylamidopropyl trimethylammonium, allylamine, 1,4-diaminobutane methacrylamide, 2-acrylamido-2-methyl-1-propanesulfonic acid, ethylene glycolmethacrylate phosphate and 2,2,2-trifluoroethyl methacrylate. 15. A polymer of claim 14, wherein the DHPD comprises at least about 1 to about 100 weight percent of the DHPp. 16. A polymer of claim 14, wherein the DHPD comprises at least about 2 to about 65 weight percent of DHPp. 17. A polymer of claim 14, wherein DHPD comprises about 3 to about 55 weight percent of DHPp.
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