Stimulus regimens for cardiovascular reflex control
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/18
A61N-001/32
출원번호
UP-0818738
(2004-04-05)
등록번호
US-7623926
(2009-12-02)
발명자
/ 주소
Rossing, Martin A.
Kieval, Robert S.
Serdar, David J.
Persson, Bruce J.
출원인 / 주소
CVRx, Inc.
대리인 / 주소
Patterson, Thuente, Skaar & Christensen, P.A.
인용정보
피인용 횟수 :
96인용 특허 :
160
초록▼
Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose
Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.
대표청구항▼
What is claimed is: 1. A method of controlling a baroreflex activation device for the treatment of hypertension, the method comprising: implanting the baroreflex activation device on or within a blood vessel proximate one or more baroreceptors, the baroreflex activation device including at least on
What is claimed is: 1. A method of controlling a baroreflex activation device for the treatment of hypertension, the method comprising: implanting the baroreflex activation device on or within a blood vessel proximate one or more baroreceptors, the baroreflex activation device including at least one electrode configured to deliver therapy to the one or more baroreceptors based on a control signal; providing a controller coupled to the baroreflex activation device; and using the controller to generate the control signal based on a therapy interval defined by a plurality of burst intervals each defined by a series of electrical pulses and including a first burst portion and a second burst portion each having a burst average power defined by a number of electrical pulses delivered over a period less than or equal to that burst portion, wherein the therapy interval includes a first therapy portion and a second therapy portion each having a therapy average power defined by a number of electrical pulses delivered over a period at least equal to a plurality of burst intervals, wherein the burst average power of the first burst portion is different than the burst average power of the second burst portion and wherein the therapy average power of the first therapy portion is different than the therapy average power of the second therapy portion. 2. The method of claim 1, wherein the first therapy portion is at least partly characterized by an initial increase in the therapy average power followed by a generally constant therapy average power followed by a decrease in therapy average power. 3. The method of claim 1, wherein each electrical pulse in the series of electrical pulses is substantially identical. 4. The method of claim 3, wherein each electrical pulse has identical pulse amplitudes and identical pulse widths. 5. The method of claim 1, wherein the burst average power of the first burst portion is greater than the burst average power of the second burst portion and wherein the therapy average power of the first therapy portion is greater than the therapy average power of the second therapy portion. 6. The method of claim 1, wherein the therapy interval is further defined by a plurality of dose intervals, each dose interval defined by a plurality of burst intervals and each dose interval having a first dose portion and a second dose portion each having a dose average power defined by a number of electrical pulses delivered over a period less than or equal to that dose portion, and wherein the therapy average power is further defined by a number of electrical pulses delivered over a period at least equal to a plurality of dose intervals. 7. The method of claim 6, wherein the first dose portion is at least partly characterized by an initial increase in the dose average power followed by a generally constant dose average power followed by a decrease in dose average power. 8. The method of claim 6 wherein any of the therapy interval, dose interval, or burst interval are triggered by a signal having a correlation with a physiologic response that is characterized by a time interval longer than a cardiac cycle. 9. The method of claim 8 wherein the physiologic response is respiration. 10. The method of claim 8 wherein the physiologic response is one or more of inspiration and expiration. 11. The method of claim 6 wherein the therapy interval is further defined by a variation in average power over a plurality of dose intervals. 12. The method of claim 1 wherein the therapy interval is on the order of minutes to hours. 13. The method of claim 1 wherein the therapy interval is of an indefinite duration. 14. The method of claim 1, wherein the burst interval is on the order of a cardiac cycle. 15. The method of claim 1, wherein the second therapy portion average power is zero. 16. The method of claim 1, wherein the baroreflex activation device includes a second electrode configured to deliver therapy to the one or more baroreceptors based on the control signal, the method further comprising interleaving the control signal between the first electrode and the second electrode. 17. The method of claim 16, further comprising interleaving the control signal between the first electrode and the second electrode at the individual pulse level. 18. The method of claim 16, further comprising interleaving the control signal between the first electrode and the second electrode at the burst level. 19. The method of claim 16, further comprising interleaving the control signal between the first electrode and the second electrode at the therapy level. 20. A method, comprising: providing a baroreflex activation device including at least one electrode configured to deliver therapy to one or more baroreceptors based on a control signal; providing a controller coupled to the baroreflex activation device; and providing instructions for controlling the baroreflex activation device for the treatment of hypertension, the instructions comprising: implanting the baroreflex activation device on or within a blood vessel proximate one or more baroreceptors; generating the control signal with the controller based on a therapy interval defined by a plurality of burst intervals each defined by a series of electrical pulses and including a first burst portion and a second burst portion each having a burst average power defined by a number of electrical pulses delivered over a period less than or equal to that burst portion, wherein the therapy interval includes a first therapy portion and a second therapy portion each having a therapy average power defined by a number of electrical pulses delivered over a period at least equal to a plurality of burst intervals, wherein the burst average power of the first burst portion is different than the burst average power of the second burst portion and wherein the therapy average power of the first therapy portion is different than the therapy average power of the second therapy portion.
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Funke Hermann D. (Bonn DEX), Acoustic body bus medical device communication system.
Schroeppel Edward A. (Miramar FL), Apparatus and method for adjusting heart/pacer relative to changes in venous diameter during exercise to obtain a requir.
Spreigl William T. ; Hess Douglas N ; Heynen Henri G.,NLX ; Struble Chester I.,NLX ; von Venrooij Paulus C.,NLX, Apparatus and method for fixing electrodes in a blood vessel.
King Gary W., Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control.
Ding, Jiang; Kramer, Andrew P.; Spinelli, Julio C., Apparatus and method for ventricular pacing triggered by detection of early ventricular excitation.
Kapp John P. (455 Bunkers Cove Rd. Panama City FL 32401) Robertson James T. (628 W. Trezevant Memphis TN 38112) Tucker Elton M. (8 Oxbow Rd. Medfield MA 02052), Arterial pressure control system.
Adkins Robert A. ; O'Donovan Cormac A. ; Terry ; Jr. Reese S., Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity.
Bozeman ; Jr. Richard J. (Dickinson TX) Akkerman James W. (Houston TX) Aber Gregory S. (Houston TX) Damm George Arthur Van (Houston TX) Bacak James W. (Houston TX) Svejkovsky Paul A. (Webster TX) Ben, Axial pump.
Kieval Robert S. ; Bettett Tom D. ; Fitts Stephanie Michele, Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure.
Dahl Roger W. (Andover MN) Swanson David K. (Roseville MN) Hahn Stephen J. (Roseville MN) Lang Douglas J. (Arden Hills MN) Heil John E. (St. Paul MN), Body implantable defibrillation system.
Ding, Jiang; Spinelli, Julio C.; Kramer, Andrew P., Cardiac rhythm management system selecting between multiple same-chamber electrodes for delivering cardiac therapy.
Fogarty Thomas J. (770 Welch Rd. Palo Alto CA 94304) Kinney Thomas B. (San Diego CA) Finn ; III James C. (Menlo Park CA), Catheter with corkscrew-like balloon.
Wolff Rodney G. (468 W. Eagle Lake Dr. Maple Grove MN 55369) Dance Creg W. (812 Benton St. Anoka MN 55303) Letac Brice (134 rue du Renard 76.000 Roven FRX) Cribier Alain (76150 Maromme Maromme FRX), Compressive stent and delivery system.
Claracq Michel (17 ; rue de Vittel 31300 Toulouse FRX), Device for partly occluding a vessel in particular the inferior vena cava and inherent component of this device.
Kieval,Robert S.; Persson,Bruce J.; Serdar,David J.; Keith,Peter T.; Irwin,Eric D., Electrode designs and methods of use for cardiovascular reflex control devices.
Fenner Andreas A. ; Larson Lary R. ; Greeninger Daniel R. ; Thompson David L., Feedthrough assembly for implantable medical devices and methods for providing same.
Nappholz Tibor A. (Englewood CO) Hursta William N. (Littleton CO) Dawson Albert K. (Denver CO) Steinhaus Bruce M. (Parker CO), Implantable ambulatory electrocardiogram monitor.
Halperin Louis E. (St. Paul MN) Lee Brian B. (Golden Valley MN) Roline Glenn M. (Anoka MN) Varrichio Anthony J. (Flanders NJ), Implantable capacitive absolute pressure and temperature monitor system.
Obel Israel W. P. (Johannesburg ZAX) Bourgeois Ivan (Verviers BEX), Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload.
Di Domenico Edward D. (Anoka MN) Hobot Christopher M. (Tonka Bay MN) Stokes Kenneth B. (Minneapolis MN) Coury Arthur J. (St. Paul MN) Doan Phong D. (Shoreview MN) Sandstrom Richard D. (Scandia MN), Medical electrical lead with polymeric monolithic controlled release device and method of manufacture.
Stroetmann Brigitte (Uttenreuth DEX) Holmstrom Nils (Jarfalla SEX) Kallert Siegfried (Erlangen DEX) Bowald Staffan (Almunge SEX), Method and apparatus for cardiac therapy by stimulation of a physiological representative of the parasympathetic nervous.
Edell David J. (Lexington MA) Wyatt ; Jr. John L. (Sudbury MA) Rizzo ; III Joseph (Boston MA), Method and apparatus for preferential neuron stimulation.
Webster ; Jr. Wilton W. ; Scherlag Benjamin J. ; Scherlag Michael ; Schauerte Patrick, Method and apparatus for transvascular treatment of tachycardia and fibrillation.
Geddes Leslie A. (West Lafayette IN) Elabbady Tarek (Kirkland WA) Schoenlein William E. (Lafayette IN) Waninger Matthew (Frankfort IN) Bourland Joe D. (West Lafayette IN), Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation.
Geddes Leslie A. ; Elabbady Tarek ; Schoenlein William E. ; Waninger Matthew ; Bourland Joe D., Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation.
Hill Michael R. S. ; Jonkman Kenneth R., Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers.
Brabec Scott J. ; Brennen Kenneth R. ; Schindeldecker William J. ; Spear Stanten C. ; Rugland Roger E. ; Johnson Bruce C., Method for tissue stimulation and fabrication of low polarization implantable stimulation electrode.
Larsen Charles E. (Cumming GA) Trip Roel (Snellville GA) Johnson Cheryl R. (Atlanta GA), Methods for procedures related to the electrophysiology of the heart.
Klein George J.,CAX ; Warkentin Dwight H. ; Riff Kenneth M. ; Lee Brian B. ; Carney James K. ; Turi Gregg ; Varrichio Anthony J., Minimally invasive implantable device for monitoring physiologic events.
Keller ; Jr. John W. (Miami FL) Bursack William E. (New Brighton MN) Coombes Alan (Brooklyn Park MN), Mutually noninterfering transcutaneous nerve stimulation and patient monitoring.
Bennett Tommy D. (Shoreview MN) Nichols Lucy M. (Maple Grove MN) Roline Glenn M. (Anoka MN) Thompson David L. (Fridley MN), Rate responsive pacemaker and pacing method.
Dahl Roger W. (Andover MN) Wickham ; deceased Robert W. (late of Harris MN by Duane Quiggle ; administrator) Swanson David K. (Roseville MN) Lipson David (Poway CA), Stent-type defibrillation electrode structures.
Lee Philip (Woodbury MN) Stokes Kenneth (Brooklyn Park MN) Gates James (Maple Grove MN) Johnson Gary (Ramsey MN), Steroid eluting cuff electrode for peripheral nerve stimulation.
Lee Philip (Woodbury MN) Stokes Kenneth (Brooklyn Park MN) Colson Michael (Minneapolis MN), Steroid eluting electrode for peripheral nerve stimulation.
Bennett Tom D. (Shoreview MN) Combs William J. (Eden Prairie MN) Kallok ; Michael J. (New Brighton MN) Lee Brian B. (Golden Valley MN) Mehra Rahul (Stillwater MN) Klein George J. (London CAX), Subcutaneous multi-electrode sensing system, method and pacer.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Zabara Jacob (Philadelphia PA), Treatment of neuropsychiatric disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of patients in coma by nerve stimulation.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H., Computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction.
Bolea, Stephen L.; Kieval, Robert S.; Persson, Bruce J.; Serdar, David J.; Keith, Peter T.; Irwin, Eric D.; Rossing, Martin A., Electrode structures and methods for their use in cardiovascular reflex control.
Bolea, Stephen L.; Kieval, Robert S.; Persson, Bruce J.; Serdar, David J.; Keith, Peter T.; Irwin, Eric D.; Rossing, Martin A., Electrode structures and methods for their use in cardiovascular reflex control.
Bolea, Stephen L.; Kieval, Robert S.; Persson, Bruce J.; Serdar, David J.; Keith, Peter T.; Irwin, Eric D.; Rossing, Martin A., Electrode structures and methods for their use in cardiovascular reflex control.
KenKnight, Bruce H.; Libbus, Imad; Amurthur, Badri; Ardell, Jeffrey L., Fine resolution identification of a neural fulcrum for the treatment of chronic cardiac dysfunction.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H., Implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H., Implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H., Implantable device for facilitating control of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H., Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H., Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H., Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring.
Libbus, Imad; Amurthur, Badri; Kenknight, Bruce H., Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H., Implantable neurostimulator for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration.
Libbus, Imad; Amurthur, Badri; Kenknight, Bruce H., Implantable neurostimulator for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration.
Libbus, Imad; Amurthur, Badri; Kenknight, Bruce H., Implantable neurostimulator for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration.
Amurthur, Badri; Libbus, Imad; KenKnight, Bruce H., Implantable neurostimulator-implemented method for managing hypertension through renal denervation and vagus nerve stimulation.
Libbus, Imad; Amurthur, Badri; Kenknight, Bruce H., Implantable neurostimulator-implemented method for managing tachyarrhythmic risk during sleep through vagus nerve stimulation.
Quintin, Lue; Cividjian, Andrei, Method and device for predicting abnormal medical events and/or assisting in diagnosis and/or monitoring, particularly in order to determine depth of anesthesia.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H.; Ardell, Jeffrey L., Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H.; Ardell, Jeffrey L., Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction.
Libbus, Imad; Amurthur, Badri; KenKnight, Bruce H.; Ardell, Jeffrey L., Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction.
KenKnight, Bruce H.; Ardell, Jeffrey L.; Libbus, Imad; Amurthur, Badri, Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction.
KenKnight, Bruce H.; Ardell, Jeffrey L.; Libbus, Imad; Amurthur, Badri, Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction.
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