초록 ▼

A method is disclosed for treating heart and vascular tissue with cryotreatment. A medical instrument, such as a catheter is positioned to contact a target region of cardiac tissue such as the epicardial tissue. The instrument or catheter provided includes a cryotreatment element that has thermally-

A method is disclosed for treating heart and vascular tissue with cryotreatment. A medical instrument, such as a catheter is positioned to contact a target region of cardiac tissue such as the epicardial tissue. The instrument or catheter provided includes a cryotreatment element that has thermally-transmissive properties. The cryotreatment element may be a cryochamber for enclosing the flow of a fluid refrigerant therein. The cryotreatment element is disposed at the situs of heart or vascular tissue to be treated, usually by piercing the epicardium sac via an opening in the patient's body. A refrigerant flow within the cryochamber creates endothermic cooling with respect to the targeted heart or vascular tissue, inducing hypothermia and forming iceballs proximate the tissue. The cooling may be reversible and non-permanent, or may be permanent leading to cell death, necrosis, apoptosis and/or surgical excision or ablation of tissue.

대표청구항 ▼

What is claimed is: 1. A method of cryogenically ablating a predetermined portion of tissue on an exterior surface of a blood vessel of a patient, the method comprising: inserting a medical instrument having a thermally-transmissive segment into the patient's body; guiding the instrument to a prede

What is claimed is: 1. A method of cryogenically ablating a predetermined portion of tissue on an exterior surface of a blood vessel of a patient, the method comprising: inserting a medical instrument having a thermally-transmissive segment into the patient's body; guiding the instrument to a predetermined portion of the patient's body and positioning the thermally-transmissive segment adjacent tissue on an exterior surface of the blood vessel to be ablated; directing a flow of cryogenic fluid to the thermally-transmissive segment; effecting a cooling of the cryogenic fluid adjacent the thermally-transmissive segment; and removing the fluid from the thermally-transmissive segment. 2. The method according to claim 1, wherein directing the flow of cryogenic fluid comprises directing the fluid to the thermally-transmissive segment through a first fluid flow passage formed in the instrument and removing the fluid comprises directing the fluid through a second fluid flow passage formed in the instrument. 3. The method according to claim 1, further comprising controlling the flow of cryogenic fluid remote from the thermally-transmissive segment to vary the temperature and rate of cooling of the tip portion. 4. The method according to claim 3, further comprising throttling the flow of cryogenic fluid to provide reversible cooling of the tissue adjacent the thermally-transmissive segment. 5. The method according to claim 1, further comprising sensing electrical activity of the tissue to be treated. 6. The method according to claim 5, wherein the sensing electrical activity and ablating the tissue occur substantially simultaneously. 7. The method of claim 1, wherein the instrument includes a thermally-transmissive segment with a focal tip. 8. The method of claim 1, wherein the instrument includes a thermally-transmissive segment with a linear tip. 9. The method of claim 1, wherein the instrument includes a thermally-transmissive segment with a curvilinear tip. 10. The method of claim 1, wherein the thermally-transmissive segment is inflatable tip.