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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | UP-0000798 (2004-11-30) |
등록번호 | US-7628780 (2009-12-16) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 26 인용 특허 : 603 |
Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated
Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.
The invention claimed is: 1. A method for epicardially injecting a substance into an area of tissue of a heart having an epicardial surface and disposed within a torso, the method comprising: providing a substance-injecting device including a suction member comprising a suction pad comprising a plu
The invention claimed is: 1. A method for epicardially injecting a substance into an area of tissue of a heart having an epicardial surface and disposed within a torso, the method comprising: providing a substance-injecting device including a suction member comprising a suction pad comprising a plurality of suction ports, a plurality of needles slidably coupled to the suction member, an elongate shaft having a longitudinal axis, a proximal region, a distal region, and a needle driver coupled to the elongate shaft distal region for driving the needles substantially parallel to the elongate shaft distal region longitudinal axis through the suction member and into tissue; making an opening into the torso; advancing the injecting device through the opening to the epicardial surface of the heart; grasping an area of tissue of the heart via the suction member; driving the needles into the area of tissue grasped by the suction member; and injecting the substance from the device into the area of tissue grasped by the suction member. 2. A method as in claim 1, wherein the making opening step includes making an intercostal opening. 3. A method as in claim 1, wherein the making opening step includes making a xiphoid opening below the sternum. 4. A method as in claim 1, wherein the injecting the substance step includes injecting a substance selected from the group consisting of bone marrow cells, stem cells, embryonic stem cells, pluripotent stem cells, mesenchymal stem cells, and satellite muscle cells. 5. A method as in claim 1, wherein the injecting the substance step includes injecting a substance selected from the group consisting of growth factors, vascular endothelial growth factors, and angiogenesis promoting agents. 6. A method as in claim 1, wherein the making opening step includes making a sternotomy. 7. A method as in claim 1, further comprising the step of sensing contractions of the heart. 8. A method as in claim 7, wherein the injecting the substance step occurs between contractions of the heart. 9. A method as in claim 8, wherein the heart is temporarily stopped using vagal nerve stimulation. 10. A method as in claim 1, further comprising: providing a suction assisted positioning device; engaging the heart with the positioning device; and, positioning the heart into a non-physiological orientation. 11. A method as in claim 10, wherein the injecting the substance step occurs following the positioning of the heart in a non-physiological orientation step. 12. A method as in claim 1, wherein the injecting the substance step includes injecting a substance selected from the group consisting of platelet rich plasma, platelet poor plasma, fibrinogen and a clotting agent. 13. A method as in claim 12, wherein the clotting agent is thrombin.
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