Accordingly, in one embodiment of the invention, a bioreactor system is presented and includes a disposable container for housing biomaterials for processing, the disposable container including at least one input port, at least one exhaust port, at least one harvest port, and the integrity of the st
Accordingly, in one embodiment of the invention, a bioreactor system is presented and includes a disposable container for housing biomaterials for processing, the disposable container including at least one input port, at least one exhaust port, at least one harvest port, and the integrity of the sterile environment is protected with sterile filters attached to all external open ports a structure for supporting the disposable container, one or more sensors for sensing one or more parameters of the biomaterials in the container, a heater for heating the contents of the container, the heater having a thermostat and mixing system arranged with the system such that biomaterials contained in the disposable container are mixed.
대표청구항▼
We claim: 1. A bioreactor system comprising: a disposable container for housing biomaterials for processing, the disposable container comprising a single chamber including at least one input port; a fitting comprising a porous surface associated with the input port and configured for allowing the p
We claim: 1. A bioreactor system comprising: a disposable container for housing biomaterials for processing, the disposable container comprising a single chamber including at least one input port; a fitting comprising a porous surface associated with the input port and configured for allowing the passage of an inlet gas stream and controlling gas bubble size and distribution prior to addition of the inlet gas stream to the interior of the single chamber, wherein the pore size of the porous surface is chosen from macro, micron, submicron, nano, and combinations thereof; a disposable mixing system comprising an impeller positioned above the porous surface and within the single chamber at a lower portion of the single chamber, the impeller configured to be driven by a motor magnetically coupled to the impeller and external to the lower portion of the single chamber such that biomaterials contained within the single chamber are mixed and gas bubble circulation is increased; at least one exhaust port; at least one harvest port; a structure for supporting the disposable container; one or more sensors for sensing one or more parameters of the biomaterials in the container; and a heater for heating the contents of the disposable container, the heater having a thermostat. 2. The bioreactor system of claim 1, wherein the disposable container comprises a plastic container or a flexible plastic bag. 3. The bioreactor system of claim 1, wherein the single chamber includes at least one baffle configured for restricting circular flow or preventing vortexing. 4. The bioreactor system of claim 1, wherein the disposable mixing system comprises a bubble column in conjunction with a partial divider positioned in the interior of the single chamber. 5. The bioreactor system of claim 1, wherein the porous surface is arranged to allow one or two-way fluid communication between an interior of the single chamber and an exterior of the single chamber. 6. The bioreactor system of claim 1, wherein the heater comprises an area of material positioned on the exterior of the disposable container. 7. The bioreactor system of claim 1, wherein the heater comprises a blanket of material or metal jacket containing heated or cooled water wrapped around at least a portion of the exterior of the disposable container. 8. The bioreactor system of claim 7, wherein the heater is positioned within the disposable container or on the exterior of the disposable container. 9. The bioreactor system of claim 1, wherein the one or more sensors comprise sensors for detecting at least one of dissolved oxygen dissolved carbon dioxide, mixing rate, gas flow rate, temperature, pH and pressure. 10. The bioreactor system of claim 1, further comprising a computer for controlling the bioreactor system. 11. The bioreactor system of claim 1, further comprising at least one of an air supply, a carbon dioxide supply, and an oxygen supply. 12. The bioreactor system of claim 1, further comprising transporting means for moving the support structure. 13. The bioreactor system of claim 12, wherein the transporting means comprises a dolly. 14. A bioreactor system comprising: a support structure; a disposable container comprising a single chamber positioned within the support structure, the disposable container including: an impeller plate affixed to a lower portion of the single chamber, the impeller plate including a post having an end projecting into the single chamber; a fitting attached to the impeller plate, the fitting comprising a porous surface arranged to allow one or two-way fluid communication between an interior of the single chamber and an exterior of the single chamber, the porous surface having a pore size chosen from macro, micron, submicron, nano, and combinations thereof; a disposable impeller hub mounted on the post, the disposable impeller hub having at least one disposable impeller blade and having at least one magnet, the at least one impeller blade positioned above the porous surface and arranged on the post; a motor having a shaft, the motor being provided adjacent to or within the support structure; and a motor hub mounted on the motor shaft, the motor hub including at least one magnet, wherein upon mounting of the disposable container comprising a single chamber within the support structure, the motor hub aligns with the impeller plate such that the magnet of the motor hub may align with the magnet of the disposable impeller hub to drive the disposable impeller hub when the motor shaft rotates. 15. The bioreactor system of claim 14, wherein the motor hub further includes a lazy-susan bearing, wherein the bearing is positioned within the hub such that a portion of the bearing contacts one side of the impeller plate. 16. The bioreactor system of claim 14, wherein the pore size of the porous surface is from about 2 microns to about 10 millimeters. 17. The bioreactor system of claim 14, wherein the fluid communication is configured for introducing a gas sparge to the interior of the disposable container or for removing fluids from the interior of the disposable container. 18. The bioreactor system of claim 14, wherein the at least one disposable impeller blade comprises a variable pitch impeller blade. 19. The bioreactor system of claim 18, wherein the pitch of the disposable impeller blade changes depending upon the rotational speed of the impeller hub. 20. The bioreactor system of claim 18, wherein the pitch of the disposable impeller blade is manually adjusted. 21. The bioreactor system of claim 1, wherein the pore size of the porous surface is from about 2 microns to about 10 millimeters. 22. The bioreactor system of claim 21, wherein the pore size of the porous surface is from about 5 microns to about 3 millimeters. 23. The bioreactor system of claim 1, wherein the porous surface associated with the input port and configured for allowing the passage of an inlet gas stream and controlling gas bubble size and distribution prior to addition of the inlet gas stream to the interior of the single chamber is also adapted for use as a particulate separation device. 24. The bioreactor system of claim 1, wherein all surfaces configured for contact with the biomaterials housed for processing are disposable. 25. The bioreactor system of claim 14, wherein the porous surface arranged to allow one or two-way fluid communication between an interior of the single chamber and an exterior of the single chamber, is also adapted for use as a particulate separation device. 26. The bioreactor system of claim 14, wherein the disposable impeller hub and the motor hub each include at least two magnets. 27. The bioreactor system of claim 16, wherein the pore size of the porous surface is from about 5 microns to about 3 millimeters.
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