IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0871185
(2007-10-12)
|
등록번호 |
US-7630084
(2009-12-16)
|
우선권정보 |
EP-06021584(2006-10-14) |
발명자
/ 주소 |
- Wehowski, Frederic
- Rosicke, Bern
- Kalveram, Stefan
|
출원인 / 주소 |
- Roche Diagnostics Operations, Inc.
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
1 인용 특허 :
7 |
초록
A system and method for measuring and evaluating optical signals for detecting an analyte in an analysis liquid.
대표청구항
▼
The invention claimed is: 1. An optical measuring device for detecting an analyte in an analysis liquid disposed on a test carrier which has an optical evaluation zone, the device comprising: a first signal generator for generating a first control signal having a first frequency and a first intensi
The invention claimed is: 1. An optical measuring device for detecting an analyte in an analysis liquid disposed on a test carrier which has an optical evaluation zone, the device comprising: a first signal generator for generating a first control signal having a first frequency and a first intensity, a second signal generator for generating a second control signal having a second frequency and a second intensity, a light source for illuminating the optical evaluation zone using a light control signal based on the first and second control signals; a light sensor for receiving light from the optical evaluation zone and for converting the received light into a measuring signal; a first frequency-selective amplifier, to which the measuring signal and the first control signal are fed and having an output for outputting a first output signal, a second frequency-selective amplifier, to which the measuring signal and the second control signal are fed and having an output for outputting a second output signal, an evaluation unit, to which the first output signal and the second output signal are fed, the evaluation unit being configured to compare the first output signal and the second output signal and to derive information about interference of the measuring signal based on the comparison. 2. The device of claim 1, further comprising a mixer unit for generating, from the first control signal and the second control signal, a light control signal for controlling light emission of the light source. 3. The device of claim 1, wherein the first and second signal generators are implemented in the same electronic component. 4. The device of claim 1, further comprising a signal source for generating a third control signal having a third frequency and a third intensity, a light control signal being generated by a mixer unit from the first control signal, the second control signal, and the third control signal, a third frequency-selective amplifier, to which the measuring signal and the third control signal of the third signal generator are fed and having an output for outputting a third output signal, and the evaluation unit being fed with the third output signal and being adapted for comparing the first output signal, the second output signal and the third output signal. 5. The device of claim 4, wherein the evaluation unit includes circuitry and programming to determine if one or more of the first, second, and third output signals are errant. 6. The device of claim 5, wherein the evaluation unit includes circuitry and programming to determine whether at least two of the first, second, and third output signals are consistent with each other. 7. The device of claim 1, wherein precisely two frequency-selective amplifiers are provided and in the event of deviation of the two output signals from a predefined comparison result, the measurement performed is recognized as faulty. 8. The device of claim 1, wherein the intensities of the first and second control signals are different. 9. The device of claim 1, wherein the first control signal is a square-wave signal having a fundamental frequency and the second control signal is a harmonic of the first control signal, the frequency of the second control signal being a multiple of the fundamental frequency, and the intensity of the second control signal being different from the intensity of the first control signal. 10. The device of claim 9, wherein the frequency of the second control signal is three times the fundamental frequency. 11. The device of claim 1, wherein the evaluation unit calculates a ratio of the first output signal and a first reference signal for generating a first referenced output signal, calculates a ratio of the second output signal and a second reference signal, for generating a second referenced output signal, and compares the first referenced output signal to the second referenced output signal. 12. The device of claim 1, wherein a first analytical result is derived in the evaluation unit from the first output signal using first calibration data, a second analytical result is derived in the evaluation unit from the second output signal using second calibration data, and the first and second analytical results are compared to obtain the information about interference of the measurement. 13. The device of claim 1, wherein a bandpass filter is located between the light sensor and the first frequency-selective amplifier. 14. The device of claim 1, wherein the first frequency-selective amplifier is software implemented in an electronic component. 15. The device of claim 1, wherein the frequency-selective amplifiers are implemented in the same electronic component. 16. A method for measuring and evaluating photometric signals for detecting an analyte in an analysis liquid, comprising the following steps: illuminating an optical evaluation zone of a test carrier by a powered light source, receiving the light remitted from the optical evaluation zone by a light sensor, converting the light received by the light sensor into a measuring signal, generating a first control signal having a first frequency and a first intensity, generating a second control signal having a second frequency and a second intensity, generating a light control signal from the first control signal and the second control signal for activating the light source, feeding the measuring signal received from the light sensor to a first frequency-selective amplifier and to a second frequency-selective amplifier, feeding the first control signal to the first frequency-selective amplifier and feeding the second control signal to the second frequency-selective amplifier, feeding a first output signal of the first frequency-selective amplifier and a second output signal of the second frequency-selective amplifier to an evaluation unit, comparing the first output signal to the second output signal in the evaluation unit, and determining information about the measuring signal from the result of the comparison. 17. The method of claim 16, wherein the first control signal is generated by a first signal generator and the second control signal is generated by a second signal generator. 18. The method of claim 16, further including the steps of generating the first output signal by calculating a ratio of the first output signal and a first reference signal, and generating the second output signal by calculating a ratio of the second output signal and a second reverence signal. 19. The method of claim 16, wherein the first control signal is a square-wave signal having a fundamental frequency and the second control signal is a harmonic of the first control signal, the frequency of the second control signal being a multiple of the fundamental frequency, and the intensity of the second control signal being different from the intensity of the first control signal. 20. The method of claim 16, wherein the comparing step includes: deriving a first analytical result in the evaluation unit from the first output signal using first calibration data, deriving a second analytical result in the evaluation unit from the second output signal using second calibration data, and comparing the first and second analytical results to obtain the information about the measuring signal. 21. The method of claim 16, wherein the determined information relates to interference due to external light.
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