It is an object of the present invention to provide magnetic substance-encapsulated particles which have uniform magnetism, high dispersion stability and a narrow particle size distribution, a method of producing the same, particles for immunoassay formed by using the magnetic substance-encapsulated
It is an object of the present invention to provide magnetic substance-encapsulated particles which have uniform magnetism, high dispersion stability and a narrow particle size distribution, a method of producing the same, particles for immunoassay formed by using the magnetic substance-encapsulated particles and a method of immunoassay in which the magnetic substance-encapsulated particles or the particles for immunoassay are used. The present invention relates to a magnetic substance-encapsulated particle, which comprises an organic polymer material and a magnetic substance having an average particle size of 1 to 30 nm, the magnetic substance being contained within a particle in a state of being dispersed.
대표청구항▼
The invention claimed is: 1. A magnetic substance-encapsulated particle, which comprises an organic polymer material and a magnetic substance, wherein the magnetic substance has an average particle size of 1 to 30 nm, the magnetic substance being dispersed and encapsulated within the organic polyme
The invention claimed is: 1. A magnetic substance-encapsulated particle, which comprises an organic polymer material and a magnetic substance, wherein the magnetic substance has an average particle size of 1 to 30 nm, the magnetic substance being dispersed and encapsulated within the organic polymer material of said particle; wherein said organic polymer material comprises a monomer not having a hydrophilic group for forming a core of said particle and a monomer having a hydrophilic group for forming a shell of said particle and forming a particle having dispersion stability in water; and wherein an absolute deviation of a component ratio between a carbon element comprising the organic polymer material and a metal element comprising the magnetic substance is 0.27 or less, wherein the monomer not having a hydrophilic group comprises a monomer having a glycidyl group and a styrenic monomer and wherein the monomer having a hydrophilic group is polyethylene glycol (meth)acrylate represented by the following general formula (1) or a compound represented by the following general formula (2): CH2═CR--COO--(CH2--CH2--O) n--H (1) in the formula, R represents H or CH3, and n represents an integer of 1 to 20, in the formula, X represents H or SO3-NH4+, and n represents an integer of 3 to 30. 2. The magnetic substance-encapsulated particle according to claim 1, wherein the magnetic substance is formed by oxidization of a metal ion within a particle in a polymerization process of forming the magnetic substance-encapsulated particle. 3. The magnetic substance-encapsulated particle according to claim 2, wherein the metal ion is an iron ion. 4. The magnetic substance-encapsulated particle according to claim 1, wherein the proportion of a monomer unit derived from the styrenic monomer in the organic polymer material is 5 to 90% by weight. 5. The magnetic substance-encapsulated particle according to claim 1, wherein the organic polymer material is crosslinked. 6. The magnetic substance-encapsulated particle according to claim 1, which has at least a functional group selected from the group consisting of a carboxyl group, a hydroxyl group, an epoxy group, an amino group, a triethylammonium group, a dimethylamino group and a sulfonic acid group at the surface of the particle. 7. The magnetic substance-encapsulated particle according to claim 1, wherein an average particle size is 0.05 to 1 μm. 8. The magnetic substance-encapsulated particle according to claim 1, wherein a content of the magnetic substance is 0.1 to 50% by weight. 9. The magnetic substance-encapsulated particle according to claim 1, wherein an average particle size of the magnetic substance is 2 to 10 nm. 10. The magnetic substance-encapsulated particle according to claim 1, wherein a linker having a functional group capable of forming a covalent bond with an antigen or an antibody binds to a particle surface. 11. The magnetic substance-encapsulated particle according to claim 10, wherein the functional group capable of forming a covalent bond with an antigen or an antibody is an epoxy group. 12. The magnetic substance-encapsulated particle according to claim 10, wherein the linker is polyethylene glycol diglycidyl ether.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (8)
Moriguchi Soyao (Tokyo JPX) Nakayama Yoshito (Tokyo JPX) Suzuki Hiroshi (Tokyo JPX) Ishii Tae (Tokyo JPX) Shioda Seiji (Tokyo JPX) Kaiho Isao (Tokyo JPX), Active support substance and adsorbent for chromatography.
Noetzel Siegfried (Kelkheim DEX) Mauz Otto (Liederbach DEX) Sauber Klaus (Bad Soden am Taunus DEX), Macroporous bead polymers, a process for their preparation and their use.
Daniel Jean-Claude (Fontenay/Sous/Bois FRX) Schuppiser Jean-Luc (Claye-Souilly FRX) Tricot ; deceased Marc (late of Andilly FRX by Nicole Tricot ; heir), Magnetic polymer latex and preparation process.
Bicerano, Jozef, Proppants coated by piezoelectric or magnetostrictive materials, or by mixtures or combinations thereof, to enable their tracking in a downhole environment.
Bicerano, Jozef, Proppants containing dispersed piezoelectric or magnetostrictive fillers or mixtures thereof, to enable proppant tracking and monitoring in a downhole environment.
Bicerano, Jozef, Proppants containing dispersed piezoelectric or magnetostrictive fillers or mixtures thereof, to enable proppant tracking and monitoring in a downhole environment.
Bicerano, Jozef, Proppants containing dispersed piezoelectric or magnetostrictive fillers or mixtures thereof, to enable proppant tracking and monitoring in a downhole environment.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.