Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07H-021/02
C07H-021/00
C07H-021/04
A01N-043/04
A01N-043/02
A61K-031/70
출원번호
UP-0173938
(2005-07-01)
등록번호
US-7632822
(2009-12-24)
발명자
/ 주소
Agrawal, Sudhir
Bhagat, Lakshmi
Yu, Dong
Kandimalla, Ekambar
출원인 / 주소
Idera Pharmaceuticals, Inc.
대리인 / 주소
Keown & Zucchero, LLP
인용정보
피인용 횟수 :
8인용 특허 :
8
초록▼
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers and an immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunomers according to the invention further comprise at least two oligonucleotides linked at their 3' ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunomodulatory oligonucleotide and having an accessible 5' end.
대표청구항▼
What is claimed is: 1. An immunostimulatory oligonucleotide having the structure 5'-CTGTCG2TTCTC-X-CTCTTG2CTGTC-5'; wherein X is a glycerol linker and G2 is arabinoguanosine. 2. A composition comprising the oligonucleotide according to claim 1 and a physiologically acceptable carrier. 3. The co
What is claimed is: 1. An immunostimulatory oligonucleotide having the structure 5'-CTGTCG2TTCTC-X-CTCTTG2CTGTC-5'; wherein X is a glycerol linker and G2 is arabinoguanosine. 2. A composition comprising the oligonucleotide according to claim 1 and a physiologically acceptable carrier. 3. The composition according to claim 2, further comprising an antibody, antisense oligonucleotide, protein, antigen, allergen, chemotherapeutic agent or adjuvant. 4. A composition comprising the oligonucleotide according to claim 1, further comprising an antibody, antisense oligonucleotide, protein, antigen, allergen, chemotherapeutic agent or adjuvant. 5. A method for generating an immune response in a mammal, the method comprising administering to the mammal an immunostimulatory oligonucleotide having the structure 5'-CTGTCG2TTCTC-X-CTCTTG2CTGTC-5'; wherein X is a glycerol linker and G2 is arabinoguanosine. 6. The method according to claim 5, wherein the route of administration is selected from the group consisting of parental, oral, sublingual, transdermal, topical, intranasal, aerosol, intraocular, intratracheal, intrarectal, vaginal, gene gun, dermal patch, eye drop and mouthwash. 7. The method according to claim 5, further comprising administering an antibody, antisense oligonucleotide, protein, antigen, allergen, chemotherapeutic agent or adjuvant.
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이 특허에 인용된 특허 (8)
Agrawal Sudhir ; Habus Ivan ; Kandimalla Ekambar R., Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides.
Froehler Brian (Belmont CA) Matteucci Mark (Burlingame CA), Enhanced triple-helix and double-helix formation with oligomers containing modified purines.
Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
Agrawal Sudhir (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses.
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