Peptide extract of lupine and pharmaceutical or cosmetic or nutritional composition comprising same
원문보기
IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
UP-0985988
(2004-11-12)
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등록번호 |
US-7638149
(2010-01-07)
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우선권정보 |
FR-99 04875(1999-04-19) |
발명자
/ 주소 |
- Msika, Philippe
- Piccirilli, Antoine
- Paul, Francois
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출원인 / 주소 |
- Laboratoires Expanscience
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
0 인용 특허 :
4 |
초록
A composition comprising a hydrolyzed peptide extract of a lupin and a method of producing the same.
대표청구항
▼
The invention claimed is: 1. A composition comprising a peptide extract of a lupin, wherein said peptide extract is lipid-depleted and contains at least 50% of peptides relative to dry extract, the composition has a sugar content lower than 1% relative to dry extract, and said peptides have a molec
The invention claimed is: 1. A composition comprising a peptide extract of a lupin, wherein said peptide extract is lipid-depleted and contains at least 50% of peptides relative to dry extract, the composition has a sugar content lower than 1% relative to dry extract, and said peptides have a molecular weight of less than 10,000 Daltons. 2. The composition of claim 1, wherein the peptide extract of lupin has metalloprotease inhibiting activity. 3. The composition of claim 1, wherein the peptide extract of lupin has collagenase inhibiting activity. 4. The composition of claim 1, wherein the peptide extract of lupin has gelatinase inhibiting activity. 5. The composition of claim 1, wherein the peptide extract of lupin has stromelysin inhibiting activity. 6. The composition of claim 1, wherein the peptide extract of lupin is a peptide extract of sweet white lupi (lupinus albus). 7. The composition of claim 6, wherein the peptide extract of sweet white lupin (lupinus albus) is a peptide extract of Ares variety of sweet white lupin (lupinus albus). 8. The composition of claim 1, wherein peptides of the peptide extract of lupin have a molecular weight of less than 10,000 Daltons. 9. The composition of claim 1, wherein the peptide extract of lupin has the following amino acid composition, expressed as a percentage by weight relative to the total weight of amino acids: % by Weight/Total Weight Amino Acids of Amino Acids ASP 11.3 GLU 23.2 SER 5.1 HIS 1.7 GLY 3.4 THR 3.2 ALA 2.8 ARG 10.3 TYR 6.1 CYS-CYS 2.4 VAL 3.8 MET 0.2 PHE 7.0 ILE 3.3 LEU 7.9 LYS 3.7 PRO 4.4. 10. The composition of claim 1, further comprising a physiologically acceptable inert vehicle. 11. A formulation for oral administration in the form of a tablet, a capsule or an ointment, wherein said formulation contains the composition according to claim 1. 12. A method for producing the composition of claim 1, comprising: (a) extracting a protein fraction from a lupin to provide a peptide extract, (b) hydrolyzing the peptide extract, and (c) recovering the hydrolyzed peptide extract; wherein step (a) comprises (i) preparing a lipid-free, ground lupin meal or a micronized lupin flour optionally containing lipid, and (ii) extracting soluble protein and saccharide fractions from said lupin meal or flour, or precipitating the proteins as the isoelectric point. 13. The method of claim 12 further wherein (b) is carried out enzymatically. 14. The method of claim 13, wherein (a) is followed by ultrafiltration of the protein fraction prior to (b). 15. The method of claim 12, wherein (b) is followed by ultrafiltration of the hydrolyzed peptide extract of lupin. 16. A method of treating a condition or disease linked to degradation of collagen or another extracellular support macroprotein in a mammal, comprising orally administering a composition comprising an effective amount of the peptide extract of lupin according to claim 1 to the mammal. 17. The method of claim 16, wherein the condition or disease is a skin lesion due to aging, or a skin lesion caused by solar radiation, tobacco use, pollution or stress. 18. The method of claim 16, wherein the composition inhibits metalloprotease activity when administered to the subject. 19. The method of claim 16, wherein the composition inhibits collagenase activity, gelatinase activity or stromelysin activity when administered to the subject. 20. The method of claim 16, wherein the peptide extract of lupin is a hydrolyzed extract of a sweet white lupin. 21. The method of claim 16, wherein the hydrolyzed peptide extract of the sweet white lupin is a hydrolyzed extract of an Ares variety of sweet white lupin. 22. The method of claim 16, wherein the mammal is a human. 23. A method of inhibiting metalloprotease activity in a mammal, comprising orally administering an effective amount of the peptide extract of lupin according to claim 1 to the mammal. 24. The method of claim 23, wherein the metalloprotease activity is collagenase activity, gelatinase activity or stromelysin activity. 25. The method of claim 23, wherein the peptide extract of lupin is a hydrolyzed extract of a sweet white lupin or a hydrolyzed extract of an Ares variety of sweet white lupin. 26. The method of claim 23, wherein the mammal is a human.
이 특허에 인용된 특허 (4)
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Perrier, Eric; Huc, Alain; Antoni, Danielle; Roussel, Coralie; Pina, Michel; Graille, Jean, Amphiphilic complexes, method for their preparation and compositions containing them.
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Cauwet-Martin Daniele,FRX ; Dubief Claude,FRX, Cosmetic compositions containing a lipid ceramide compound and a peptide having a fatty chain, and their uses.
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Murad, Howard, Method of treating dermatological disorders with fruit extracts.
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Johnson Lawrence A. (College Station TX) Wen Hwei-mei (Taipei TWX), Process for the preparation of protein isolates of improved quality from vegetable protein sources using alkali metal bo.
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