Drug release from antithrombogenic multi-layer coated stent
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-033/10
A61L-033/00
A61L-033/12
A61L-002/06
A61L-002/04
출원번호
UP-0797629
(2004-03-09)
등록번호
US-7638158
(2010-01-07)
발명자
/ 주소
Byun, Youngro
Yoon, Jung Han
출원인 / 주소
Mediplex Corporation, Korea
대리인 / 주소
Clayton, Howarth & Cannon, P.C.
인용정보
피인용 횟수 :
0인용 특허 :
29
초록▼
A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(s) dispersed therein. The second layer is co
A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(s) dispersed therein. The second layer is comprised of a hydrophobic heparinized polymer that inhibits blood coagulation and provides a hydrophilic surface for reducing the friction between stent and lesion site. In preferred embodiments of the invention, the multi-layered stent is effective in deterring restenosis and thrombosis at the implant site. In these same preferred embodiments, the multi-layered stent is capable of reducing the burst release of the biologically active agents from the first layer and sustaining a release of an effective amount of these agents for a relatively extended period of time. Methods of applying the multi-layered coating to the stent surface are also part of this invention.
대표청구항▼
The subject matter claimed is: 1. A method for preventing burst release of a biologically active agent dispersed in a thin film polymer layer on a stent comprising applying a second layer over the thin film polymer layer; said second layer being comprised of a hydrophobic heparinized polymer compri
The subject matter claimed is: 1. A method for preventing burst release of a biologically active agent dispersed in a thin film polymer layer on a stent comprising applying a second layer over the thin film polymer layer; said second layer being comprised of a hydrophobic heparinized polymer comprising a macromolecule, a hydrophobic material, and heparin bound together by covalent bonds, wherein the macromolecule comprises a protein selected from protamine, polylysine, polyaspartic acid, polyglutamic acid, and their derivatives and copolymers, or wherein the hydrophobic material is selected from octadecylamine, alkanoic amine, bile acids, sterols, alkanoic acids, and mixtures thereof. 2. A method for inhibiting thrombosis in a medical device having a surface in contact with an organic fluid comprising coating the surface of the medical device with an antithrombogenic heparinized polymer layer comprising a macromolecule, a hydrophobic material, and heparin bound together by covalent bonds, wherein the macromolecule comprises a protein selected from protamine, polylysine, polyaspartic acid, polyglutamic acid, and their derivatives and copolymers, or wherein the hydrophobic material is selected from octadecylamine, alkanoic amine, bile acids, sterols, alkanoic acids, and mixtures thereof. 3. The method of claim 2 further comprising applying a lowermost coating, said lowermost coating disposed under the hydrophobic heparinized polymer layer and comprising an polymer having a biologically active agent dispersed therein. 4. A method for preparing an article of manufacture comprising a stent and a coating disposed thereon, the coating comprising a first layer and a second layer, the first layer comprising a polymer film with a biologically active agent dispersed therein, and the second layer comprising an antithrombogenic heparinized polymer comprising a macromolecule, a hydrophobic material, and heparin bound together with covalent bonds, wherein the macromolecule comprises a protein selected from protamine, polylysine, polyaspartic acid, polyglutamic acid, and their derivatives and copolymers, the method comprising: cleaning the stent with a washing agent, preparing the first layer by combining the polymer and biologically active agent with a solvent, thereby forming a polymer and biologically active agent mixture and applying the mixture to the stent, preparing the second layer by combining the antithrombogenic heparinized polymer with a solvent and applying the second layer by immersing the stent in the antithrombogenic heparinized polymer and solvent solution and then drying the stent. 5. The method of claim 4 further comprising adding a second biologically active agent to the polymer and biologically active agent mixture. 6. The method of claim 4 wherein applying the first layer coating comprises dipping the stent into the polymer and biologically active agent mixture. 7. The method of claim 4 wherein applying the first layer coating comprises spraying the polymer and biologically active agent mixture onto the stent. 8. The method of claim 4 wherein the polymer film is selected from polyurethanes, polyethylene terephthalate, PLLA-poly-glycolic acid (PGA) copolymer (PLGA), polycaprolactone, poly-(hydroxybutyrate/hydroxyvalerate) copolymer, poly(vinylpyrrolidone), polytetrafluoroethylene, poly(2-hydroxyethylmethacrylate) , poly(etherurethane urea), silicones, acrylics, epoxides, polyesters, urethanes, parlenes, polyphosphazene polymers, fluoropolymers, polyamides, polyolefins, and mixtures thereof. 9. The method of claim 4 wherein the biologically active agent dispersed in the first layer is selected from antithrombotics, anticoagulants, antiplatelet agents, thrombolytics, antiproliferatives, anticancer drugs, antiinflammatory drugs, agents that inhibit restenosis, smooth muscle cell inhibitors, antibiotics, and mixtures thereof. 10. The method of claim 4 wherein the heparin is selected from recombinant heparin, heparin derivatives, and heparin analogues. 11. A method for preparing an article of manufacture comprising a stent and a coating disposed thereon, the coating comprising a first layer and a second layer, the first layer comprising a polymer film with a biologically active agent dispersed therein, and the second layer comprising an antithrombogenic heparinized polymer comprising a macromolecule, a hydrophobic material, and heparin bound together with covalent bonds, wherein the macromolecule comprises a biopolymer selected from gelatin, collagen, alginate, hyalunic acid, alginic acid, carrageenan, chondroitin, pectin, chitosan, and their derivatives and copolymers, the method comprising: cleaning the stent with a washing agent, preparing the first layer by combining the polymer and biologically active agent with a solvent, thereby forming a polymer and biologically active agent mixture and applying the mixture to the stent, preparing the second layer by combining the antithrombogenic heparinized polymer with a solvent and applying the second layer by immersing the stent in the antithrombogenic heparinized polymer and solvent solution and then drying the stent. 12. A method for preparing an article of manufacture comprising a stent and a coating disposed thereon, the coating comprising a first layer and a second layer, the first layer comprising a polymer film with a biologically active agent dispersed therein, and the second layer comprising an antithrombogenic heparinized polymer comprising a macromolecule, a hydrophobic material, and heparin bound together with covalent bonds, wherein the hydrophobic material is selected from octadecylamine, alkanoic amine, bile acids, sterols, alkanoic acids, and mixtures thereof, the method comprising: cleaning the stent with a washing agent, preparing the first layer by combining the polymer and biologically active agent with a solvent, thereby forming a polymer and biologically active agent mixture and applying the mixture to the stent, preparing the second layer by combining the antithrombogenic heparinized polymer with a solvent and applying the second layer by immersing the stent in the antithrombogenic heparinized polymer and solvent solution and then drying the stent. 13. The method of claim 12 further comprising adding a second biologically active agent to the polymer and biologically active agent mixture. 14. The method of claim 12 wherein applying the first layer coating comprises dipping the stent into the polymer and biologically active agent mixture. 15. The method of claim 12 wherein applying the first layer coating comprises spraying the polymer and biologically active agent mixture onto the stent. 16. The method of claim 12 wherein the polymer film is selected from polyurethanes, polyethylene terephthalate, PLLA-poly-glycolic acid (PGA) copolymer (PLGA), polycaprolactone, poly-(hydroxybutyrate/hydroxyvalerate) copolymer, poly(vinylpyrrolidone), polytetrafluoroethylene, poly(2-hydroxyethylmethacrylate), poly(etherurethane urea), silicones, acrylics, epoxides, polyesters, urethanes, parlenes, polyphosphazene polymers, fluoropolymers, polyamides, polyolefins, and mixtures thereof. 17. The method of claim 12 wherein the biologically active agent dispersed in the first layer is selected from antithrombotics, anticoagulants, antiplatelet agents, thrombolytics, antiproliferatives, anticancer drugs, antiinflammatory drugs, agents that inhibit restenosis, smooth muscle cell inhibitors, antibiotics, and mixtures thereof. 18. The method of claim 12 wherein the macromolecule comprises a protein selected from protamine, polylysine, polyaspartic acid, polyglutamic acid, and their derivatives and copolymers. 19. The method of claim 12 wherein the heparin is selected from recombinant heparin, heparin derivatives, and heparin analogues.
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