Lyophilization unit with liquid nitrogen cooling
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
F25D-017/02
F25B-007/00
F25D-017/04
F26B-021/06
F26B-005/06
A23C-001/06
A23C-003/00
A23L-003/36
C12C-007/26
출원번호
UP-0277995
(2006-03-30)
등록번호
US-7640756
(2010-02-11)
발명자
/ 주소
Brahmbhatt, Sudhir R.
출원인 / 주소
American Air Liquide, Inc.
대리인 / 주소
Cronin, Christopher E.
인용정보
피인용 횟수 :
0인용 특허 :
8
초록▼
An integrated industrial plant includes various systems, all of which use a cryogenic liquid obtained from a common source. One system includes a fermentation unit, in which cold air, chilled by heat exchange with the cryogenic liquid, absorbs excess heat generated by the fermentation. Another syste
An integrated industrial plant includes various systems, all of which use a cryogenic liquid obtained from a common source. One system includes a fermentation unit, in which cold air, chilled by heat exchange with the cryogenic liquid, absorbs excess heat generated by the fermentation. Another system is a lyophilization unit, in which a refrigeration step is performed through the use of air that has been chilled by heat exchange with the cryogenic liquid. Another system is a device for freezing discrete samples of biological products, the samples being frozen by partial immersion in the cryogenic liquid. The invention substantially reduces the use of electric power, and provides systems which operate economically and reliably.
대표청구항▼
What is claimed is: 1. In a lyophilization system, the system comprising a lyophilization chamber having a plurality of shelves, a product holder adapted to hold products to be treated, a silicon oil heater/cooler adapted to heat and cool said products via channels or tubes within said shelves, a v
What is claimed is: 1. In a lyophilization system, the system comprising a lyophilization chamber having a plurality of shelves, a product holder adapted to hold products to be treated, a silicon oil heater/cooler adapted to heat and cool said products via channels or tubes within said shelves, a vacuum pump for drawing air from the chamber and thereby reducing pressure in the chamber, and a refrigeration unit for cooling air which has been drawn out of the chamber, the refrigeration unit including a refrigeration coil and a compressor for conveying a refrigerant through the coil, the improvement comprising: a) a source of cryogenic liquid, b) a conduit adapted to convey a stream of cooled air into the refrigeration coil instead of the refrigerant, and c) an air stream cooler adapted to cool said stream of cooled air by transferring heat from said air to said cryogenic liquid, wherein the air stream cooler includes a first heat exchanger connected to the source of cryogenic liquid, and a second heat exchanger connected to said conduit adapted to convey said stream of cooled air and connected to a conduit adapted to withdraw air from the refrigeration coil, the first and second heat exchangers being thermally connected through a heat transfer liquid which circulates through both of said first and second heat exchangers. 2. The improvement of claim 1, further comprising means for drying a stream of ambient air and for conveying dried air into the lyophilization chamber. 3. The improvement of claim 2, wherein the drying means comprises a third heat exchanger connected to receive a cold heat transfer liquid. 4. The improvement of claim 1, further comprising means for drying a stream of ambient air and for conveying the dried air into the lyophilization chamber, wherein the drying means comprises a third heat exchanger connected to receive a cold heat transfer liquid. 5. The improvement of claim 3, wherein the cold heat transfer liquid is the same as the heat transfer liquid circulating through said first and second heat exchangers. 6. The improvement of claim 1, wherein the source of cryogenic liquid is connected to at least one distinct system in addition to the lyophilization system. 7. The improvement of claim 6, wherein said at least one distinct system is selected from the group consisting of a cryocooling system, a cryogrinding system, a cryogen rapid cooling system, a diagnostic products manufacturing unit, an inerting and blanketing unit, and a fermentation unit. 8. In a lyophilization process, the process including passing dried air over products to be treated, such that the dried air receives moisture released from the products, and conveying the moisture-containing air to a refrigeration unit for removal of water from said moisture-containing air, the improvement wherein water is removed from said moisture-containing air by passing said air over a coil which is cooled by cold air instead of a refrigerant, said cold air has been chilled by heat exchange with a heat transfer liquid at a second heat exchanger, the heat transfer liquid circulating between the second heat exchanger and a first heat exchanger at which the heat transfer liquid exchanges heat with a source of cryogenic liquid. 9. The improvement of claim 8, further comprising using said cryogenic liquid in at least one other distinct process simultaneously with said lyophilization process. 10. The improvement of claim 9, further comprising selecting said at least one other distinct process from the group consisting of cryocooling, cryogrinding, cryogen rapid cooling, diagnostic products manufacturing, inerting and blanketing, and fermentation. 11. In a lyophilization process, the process including passing a first portion of air over products to be treated, the first portion of air being dried such that the dried air receives moisture released from the products to produce moisture-containing air, and conveying the moisture-containing air to a refrigeration unit for removal of water from said moisture-containing air, the improvement comprising: a) passing a cryogenic liquid through a first heat exchanger, b) passing a second portion of air through a second heat exchanger, c) circulating a heat transfer liquid between said first and second heat exchangers, so as to cause said second portion of air to become chilled by heat exchange with said cryogenic liquid, and d) conveying the chilled air through a refrigeration coil in said refrigeration unit instead of a refrigerant so as to remove water from said moisture-containing air. 12. The improvement of claim 11, further comprising using said cryogenic liquid in at least one other distinct process simultaneously with said lyophilization process. 13. The improvement of claim 12, further comprising selecting said at least one other distinct process from the group consisting of cryocooling, cryogrinding, cryogen rapid cooling, diagnostic products manufacturing, inerting and blanketing, and fermentation. 14. The improvement of claim 11, further comprising cooling a stream of ambient air by heat exchange with a heat transfer medium which is cooled by heat exchange with a cryogenic liquid, and directing the cooled stream of ambient air towards the products to be treated. 15. The improvement of claim 14, further comprising selecting the heat transfer medium for cooling the ambient air to be the same as the heat transfer liquid of step (c). 16. The improvement of claim 14, further comprising selecting the cryogenic liquid of step (a) to come from a same source as the cryogenic liquid used to cool the heat transfer medium. 17. The improvement of claim 16, further comprising selecting the cryogenic liquid to be nitrogen.
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이 특허에 인용된 특허 (8)
Bergman ; Jr. Thomas J. (Clarence Center NY) Roberts Mark J. (Grand Island NY) Acharya Arun (East Amherst NY) Heim Carl J. (Amherst NY) Czikk Alfred M. (Amherst NY), Cooling system employing a primary, high pressure closed refrigeration loop and a secondary refrigeration loop.
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