Process and apparatus for treating implants comprising soft tissue
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-002/00
A61L-002/18
A61L-009/00
B01D-011/02
B01D-012/00
B01D-015/00
B08B-003/00
출원번호
UP-0828653
(2004-04-20)
등록번호
US-7648676
(2010-02-22)
발명자
/ 주소
Mills, C. Randal
Bianchi, John R.
Roberts, Michael R.
Nataraj, Chandrasekaran
출원인 / 주소
RTI Biologics, Inc.
대리인 / 주소
McAndrews, Held & Malloy, Ltd.
인용정보
피인용 횟수 :
33인용 특허 :
59
초록▼
The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons and ligaments, and to implants produced by such processes. The present invention is a
The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons and ligaments, and to implants produced by such processes. The present invention is also directed to processes and apparatus for improved processing of implants that include soft tissue, by applying kinematic restraint, preferably tension, to the implant or specific portions of the implants during the treatment, and to implants produced by such processes and apparatus. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity.
대표청구항▼
What is claimed is: 1. A process for making an implant more suitable for implantation into a recipient, wherein the implant at least partially comprises a soft tissue, the process comprising: (a) contacting the implant with a protective agent selected from the group consisting of alcohols and polyo
What is claimed is: 1. A process for making an implant more suitable for implantation into a recipient, wherein the implant at least partially comprises a soft tissue, the process comprising: (a) contacting the implant with a protective agent selected from the group consisting of alcohols and polyols; (b) contacting the implant with an oxidizing sterilant; and (c) contacting the implant with a rinsing fluid, further comprising applying tension to the soft tissue at least during part of step (b). 2. The process of claim 1, wherein at least one of steps (a), (b) or (c) further comprises cyclically increasing and decreasing pressure during the contact with the implant. 3. The process of claim 1, further comprising: (d) contacting the implant with an oxidizing sterilant; and (e) contacting the implant with a rinsing fluid. 4. The process of claim 3, wherein at least one of steps (a) through (e) further comprises cyclically increasing and decreasing pressure during the contact with the implant. 5. The process of claim 1, further comprising the step of rinsing the implant with an aqueous solution between steps (b) and (c). 6. The process of claim 1 wherein prior to step (b), the implant contains an amount of the alcohol in the soft tissue sufficient to reduce damage from oxidation to the soft tissue. 7. The process of claim 1, wherein the rinsing fluid is selected from the group consisting of alcohols, polyols, acetone, water, and mixtures thereof. 8. The process of claim 1, wherein the rinsing fluid comprises a monohydric alcohol having one to eight carbon atoms. 9. The process of claim 1, wherein step (b) comprises contacting the implant with an aqueous solution comprising hydrogen peroxide in a concentration range of from about 1% to about 10%. 10. The process of claim 1, wherein the implant comprises at least one tendon or ligament. 11. The process of claim 1, wherein the implant comprises a tendon having bone attached thereto. 12. A process for making an implant more suitable for implantation into a recipient, wherein the implant at least partially comprises a soft tissue, the process comprising: (a) contacting the implant with a protective agent selected from the group consisting of alcohols and polyols; (b) contacting the implant with an oxidizing sterilant; and (c) contacting the implant with a rinsing fluid, further comprising: applying kinematic restraint to the soft tissue during each of steps (a), (b) and (c). 13. The process of claim 12, wherein at least one of steps (a), (b) or (c) further comprises cyclically increasing and decreasing pressure during the contact with the implant. 14. The process of claim 12, further comprising: (d) contacting the implant with an oxidizing sterilant; and (e) contacting the implant with a rinsing fluid. 15. The process of claim 14, wherein at least one of steps (a) through (e) further comprises cyclically increasing and decreasing pressure during the contact with the implant. 16. The process of claim 12, further comprising the step of rinsing the implant with an aqueous solution between steps (b) and (c). 17. The process of claim 12 wherein prior to step (b), the implant contains an amount of the alcohol in the soft tissue sufficient to reduce damage from oxidation to the soft tissue. 18. The process of claim 12, wherein the rinsing fluid is selected from the group consisting of alcohols, polyols, acetone, water, and mixtures thereof. 19. The process of claim 12, wherein the rinsing fluid comprises a monohydric alcohol having one to eight carbon atoms. 20. The process of claim 12, wherein step (b) comprises contacting the implant with an aqueous solution comprising hydrogen peroxide in a concentration range of from about 1% to about 10%. 21. The process of claim 12, wherein the implant comprises at least one tendon or ligament. 22. The process of claim 12, wherein the implant comprises a tendon having bone attached thereto. 23. A process for treating an implant so as to sterilize the implant prior to implantation, the implant comprising a soft tissue, the process comprising: applying tension to the soft tissue while contacting the soft tissue with a cleaning agent. 24. The process of claim 23 wherein from about 0.5 Newton to about 20 Newtons of tension are applied to the soft tissue. 25. The process of claim 23 wherein from about 1 Newton to about 10 Newtons of tension are applied to the soft tissue. 26. The process of claim 23 wherein from about 3 Newtons to about 5 Newtons of tension are applied to the soft tissue. 27. The process of claim 23 wherein the cleaning agent comprises an oxidizing sterilant. 28. The process of claim 27 wherein the oxidizing sterilant is a peroxide. 29. The process of claim 28, wherein the peroxide is an aqueous solution of hydrogen peroxide. 30. The process of claim 23 wherein the cleaning agent comprises a disinfectant. 31. The process of claim 23 wherein the cleaning agent is a decontaminating agent. 32. The process of claim 23 wherein the cleaning agent comprises a detergent. 33. The process of claim 23 wherein the cleaning agent is selected from the group consisting of alcohols, polyols, detergents, and mixtures and combinations thereof. 34. The process of claim 23 further comprising the step of contacting the implant with an alcohol before contact with the cleaning agent. 35. The process of claim 23, further comprising the step of contacting the implant with a rinsing fluid after contact with the cleaning agent. 36. The process according to any of claims 23, 30, 31, 32, or 33, further comprising the step of cyclically increasing and decreasing pressure while the cleaning agent contacts the implant. 37. The process of claim 23 wherein the implant comprises at least one tendon or ligament. 38. The process of claims 23 wherein the implant comprises a tendon having bone attached thereto. 39. A process for making an implant more suitable for implantation into a recipient, wherein the implant at least partially comprises a soft tissue, the process comprising: (a) contacting the implant with an alcohol; (b) contacting the implant with a peroxide for less than about 80 minutes; (c) contacting the implant with an alcohol; and (d) applying tension to the implant during at least one of steps (a), (b) or (c). 40. A process for making an implant more suitable for implantation into a recipient, wherein the implant at least partially comprises a soft tissue, the process comprising: applying tension to the implant; perfusing the tensioned implant with an alcohol; and perfusing the tensioned implant with a peroxide for less than about 80 cumulative minutes.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (59)
Shah Mrugesh K., Apparatus and method for promoting growth and repair of soft tissue.
Brendel Klaus (Tucson AZ) Duhamel Raymond C. (Tucson AZ), Body implants of extracellular matrix and means and methods of making and using such implants.
Abraham Ginger A. ; Carr ; Jr. Robert M. ; Kemp Paul D.,GBX ; Mercer Ryan ; Baker Linda, Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix.
Young Jack H. (Crawford PA) Karle David A. (Erie PA) Halleck Frank E. (Erie PA), Combined ultrasonic cleaning and biocidal treatment in a single pressure vessel.
McNally Robert T. (Marietta GA) Heacox Albert (Marietta GA) Brockbank Kelvin G. M. (Marietta GA) Bank Harvey L. (Charleston SC), Method for cryopreserving heart valves.
Scarborough Nelson L. ; Morris John W. ; Russell James L. ; Dowd Michael, Pressure flow system and method for treating a fluid permeable workpiece such as a bone.
Wolfinbarger ; Jr. Lloyd, Process and composition for cleaning soft tissue grafts optionally attached to bone and soft tissue and bone grafts produced thereby.
Fages Jacques,FRX ; Marty Alain,FRX ; Combes Didier,FRX ; Condoret Jean-Stephane,FRX, Process for treating bone tissue and corresponding implantable biomaterials.
Jackson David P. (22328 W. Barcotta Dr. Santa Clarita CA 91350) Lepp Michael A. (22334 W. Barcotta Dr. Santa Clarita CA 91350), Processes for cleaning, sterilizing, and implanting materials using high energy dense fluids.
Lefevre Didier (Mantes la Ville FRX) Voltas Nadine (Bordeaux FRX) Champseix Henri (Montesson FRX), Reagent for use in automatic analyzers for distinguisher leukocyte sub-populations in blood samples.
Dove, Jeffrey S.; Tian, Bin; Schneider, Ralph; Cohen, Jeffrey S.; Jankovic, Ivan; Migliazza, John F.; Wright, Gregory A.; Young, James M.; Campbell, Louis A., Methods of conditioning sheet bioprosthetic tissue.
Dove, Jeffrey S.; Tian, Bin; Schneider, Ralph; Cohen, Jeffrey S.; Jankovic, Ivan; Migliazza, John F.; Wright, Gregory A.; Young, James M.; Campbell, Louis A., Methods of conditioning sheet bioprosthetic tissue.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.