Method for lowering blood pressure in pre-hypertensive individuals and/or individuals with metabolic syndrome
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-036/87
A61K-036/00
출원번호
UP-0528937
(2006-09-27)
등록번호
US-7651707
(2010-02-24)
발명자
/ 주소
Kappagoda, Chulani Tissa
출원인 / 주소
The Regents of the University of California
대리인 / 주소
Kenyon & Kenyon LLP
인용정보
피인용 횟수 :
2인용 특허 :
3
초록▼
The present invention relates to a method of treating Metabolic Syndrome and/or the conditions that comprise Metabolic Syndrome by administering to a mammal, including a human, a dietary supplement comprising grape extract. This invention also relates to a method of treating pre-hypertension by admi
The present invention relates to a method of treating Metabolic Syndrome and/or the conditions that comprise Metabolic Syndrome by administering to a mammal, including a human, a dietary supplement comprising grape extract. This invention also relates to a method of treating pre-hypertension by administering to a mammal, including a human, a dietary supplement comprising grape extract.
대표청구항▼
The invention claimed is: 1. A method of treating Metabolic Syndrome in a mammal in need thereof, comprising administering to the mammal a composition comprising a polyphenol extract from grapes in an amount effective to lower blood pressure, wherein the extract comprises about 2% by weight or less
The invention claimed is: 1. A method of treating Metabolic Syndrome in a mammal in need thereof, comprising administering to the mammal a composition comprising a polyphenol extract from grapes in an amount effective to lower blood pressure, wherein the extract comprises about 2% by weight or less epicatechin-gallate terminal units, and monomers, dimers, trimers, tetramers and pentamers in a total amount between about 25-50% by weight of the extract. 2. The method of claim 1, wherein the extract comprises about 80% by weight or more total phenolic compounds. 3. The method of claim 2, wherein the extract comprises about 12% by weight or less epicatechin-gallate extension units. 4. The method of claim 1, wherein the amount of extract in the composition is between about 50-1000 mg. 5. The method of claim 1, wherein the composition is formulated for oral administration. 6. The method of claim 5, wherein the composition is administered in a form selected from the group consisting of tablets, powders, liquids, capsules and gels. 7. The method of claim 5, wherein the composition is a food or a beverage product. 8. The method of claim 5, wherein the composition is a nutraceutical. 9. The method of claim 1, wherein the mammal is a human. 10. The method of claim 1, wherein the extract contains 400-1500 ppm of gallic acid. 11. A method of treating pre-hypertension in a mammal in need thereof, comprising administering to the mammal a composition comprising a polyphenol extract from grapes in an amount effective to lower blood pressure, wherein the extract comprises about 2% by weight or less epicatechin-gallate terminal units, and wherein the total amount of monomers, dimers, trimers, tetramers and pentamers is between about 25- 50% by weight. 12. The method of claim 11, wherein the extract comprises about 80% by weight or more total phenolic compounds. 13. The method of claim 12, wherein the extract comprises about 12% by weight or less epicatechin-gallate extension units. 14. The method of claim 11, wherein the amount of extract in the composition is between about 50-1000 mg. 15. The method of claim 11, wherein the composition is formulated for oral administration. 16. The method of claim 15, wherein the composition is administered in a form selected from the group consisting of tablets, powders, liquids, capsules and gels. 17. The method of claim 15, wherein the composition is a food or a beverage product. 18. The method of claim 15, wherein the composition is a nutraceutical. 19. The method of claim 11, wherein the mammal is a human. 20. The method of claim 11, wherein the extract contains 400-1500 ppm of gallic acid. 21. A method of treating Metabolic Syndrome in a mammal in need thereof, comprising administering to the mammal a composition comprising a polyphenol extract from grapes in an amount effective to reduce oxidized LDL cholesterol, wherein the extract comprises about 2% by weight or less epicatechin-gallate terminal units, and wherein the total amount of monomers, dimers, trimers, tetramers and pentamers is between about 25-50% by weight. 22. The method of claim 21, wherein the extract comprises about 80% by weight or more total phenolic compounds. 23. The method of claim 22, wherein the extract comprises about 12% by weight or less epicatechin-gallate extension units. 24. The method of claim 21, wherein the amount of extract in the composition is between about 50-1000 mg. 25. The method of claim 21, wherein the composition is formulated for oral administration. 26. The method of claim 25, wherein the composition is administered in a form selected from the group consisting of tablets, powders, liquids, capsules and gels. 27. The method of claim 25, wherein the composition is a food or a beverage product. 28. The method of claim 25, wherein the composition is a nutraceutical. 29. The method of claim 21, wherein the mammal is a human. 30. The method of claim 21, wherein the extract contains 400-1500 ppm of gallic acid. 31. A method of treating Metabolic Syndrome in a mammal in need thereof, comprising administering to the mammal a composition comprising a polyphenol extract from grapes having about 5-15% monomers, about 5-20% dimers, about 3-10% trimers, about 2-10% tetramers, and about 2-10% pentamers by weight, wherein the extract comprises about 2% by weight or less epicatechin-gallate terminal units. 32. The method of claim 31, wherein the extract contains 400-1500 ppm of gallic acid. 33. A method of treating pre-hypertension in a mammal in need thereof, comprising administering to the mammal a composition comprising a polyphenol extract from grapes having about 5-15% monomers, about 5-20% dimers, about 3-10% trimers, about 2-10% tetramers, and about 2-10% pentamers by weight, wherein the extract comprises about 2% by weight or less epicatechin-gallate terminal units. 34. The method of claim 33, wherein the extract contains 400-1500 ppm of gallic acid. 35. A method of treating Metabolic Syndrome in a mammal in need thereof, comprising administering to the mammal a composition comprising a polyphenol extract from grapes in an amount effective to lower blood pressure, wherein the extract comprises about 2% by weight or less epicatechin-gallate terminal units, and between about 5-15% monomers, about 5-20% dimers, about 3-10% trimers, about 2-10% tetramers, and about 2-10% pentamers by weight.
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이 특허에 인용된 특허 (3)
Bouwens Elisabeth Cornelia,NLX ; Trivedi Ketan,INX ; van Vliet Cornelis,NLX ; Winkel Cornelis,NLX, Method of enhancing color in a tea-based foodstuff.
Shrikhande, Anil J.; Race, Edward J.; Wightman, JoLynne D.; Sambueso, Robert D., Process for extraction, purification and enrichment of polyphenolic substances from whole grapes, grape seeds and grape pomace.
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