Methods for reducing adverse effects of feeding formula to infants
IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
UP-0064994
(2005-02-24)
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등록번호 |
US-7651716
(2010-02-24)
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발명자
/ 주소 |
- Davis, Anne Marie M.
- Kuhlman, Charles F.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
4 인용 특허 :
14 |
초록
▼
Methods for reducing side-effects of feeding an individual are provided. The methods comprise administering to the individual a composition comprising an amount of bovine milk providing 1.0 to 1.2 grams of protein per 100 available kilocalories and an amount of a bovine whey material providing 1.0 t
Methods for reducing side-effects of feeding an individual are provided. The methods comprise administering to the individual a composition comprising an amount of bovine milk providing 1.0 to 1.2 grams of protein per 100 available kilocalories and an amount of a bovine whey material providing 1.0 to 1.2 grams of protein per 100 available kilocalories, said bovine whey material having an alpha-lactalbumin content of 28% to 40% and a beta-lactoglobulin content of 8% to 33% of total protein.
대표청구항
▼
What is claimed is: 1. A method for reducing one or more side-effects of feeding an individual an infant formula, the method comprising administering to said individual a composition, wherein the composition comprises an amount of bovine milk providing 1.0 to 1.2 grams of protein per 100 available
What is claimed is: 1. A method for reducing one or more side-effects of feeding an individual an infant formula, the method comprising administering to said individual a composition, wherein the composition comprises an amount of bovine milk providing 1.0 to 1.2 grams of protein per 100 available kilocalories and an amount of a bovine whey material providing 1.0 to 1.2 grams of protein per 100 available kilocalories, said bovine whey material having an alpha-lactalbumin content of 28% to 40% and a beta-lactoglobulin content of 8% to 33% of total protein. 2. The method of claim 1 wherein the bovine whey material of said composition has an alpha-lactalbumin content of 28% to 36% and a beta-lactoglobulin content of 10% to 29% of total protein. 3. The method of claim 2, wherein the most abundant whey protein of the composition is alpha-lactalbumin. 4. The method of claim 1 wherein the bovine whey material of said composition is further characterized by: (a) a non-protein nitrogen content of 15% or less of total nitrogen; (b) a total protein content of 12.5% to 95%; (c) a fat content of 15% or less; and (d) an ash content of 4.5% or less. 5. The method of claim 4 wherein the bovine whey material of said composition has a total protein content of 35% to 80%. 6. The method of claim 5, wherein the bovine whey material of said composition has a total protein content of 73% to 77%. 7. The method of claim 1, wherein the bovine whey material of said composition is further characterized by amino acid contents of no less than the following, in grams per 100 grams of total protein: (a) Arginine, 3.1; (b) Cystine, 1.4; (c) Histidine, 1.6; (d) Isoleucine, 1.0; (e) Leucine, 5.3; (f) Lysine 3.9; (g) Methionine, 0.3; (h) Phenylalanine, 1.2 (i) Threonine, 3.2; (j) Tryptophan, 1.5; (k) Tyrosine, 0.9; and (l) Valine, 1.0. 8. The method of claim 1, wherein the amount of alpha-lactalbumin in said composition is no less than 2.2 grams per 670 available kilocalories (0.33 g/100 kcal). 9. The method of claim 1 wherein the side-effects are gastric side-effects. 10. The method of claim 1 wherein the subject is a human infant. 11. The method of claim 1 wherein side-effects are reduced by at least 20% in the subject as compared to a control subject. 12. The method of claim 11 wherein the control subject is administered an equivalent amount of a traditional infant formula. 13. The method of claim 1 wherein side-effects are reduced by at least 50% in the subject as compared to a control subject. 14. The method of claim 1 wherein the side-effect is selected from the group consisting of eructation, constipation, gastroesophogeal reflux disease, abdominal pain, vomiting, diarrhea and regurgitation. 15. The method of claim 1 wherein more than one side-effect is reduced in the individual. 16. The method of claim 1 further comprising administering an amount of one or more traditional infant formulas. 17. A method of producing a food composition, the method comprising: (a) adding an amount of skim milk sufficient to provide about X kg of protein to water to yield mixture 1; (b) adding about 0.02528X kg of sodium citrate and 0.0144X kg potassium bicarbonate dissolved in water to mixture 1 to yield mixture 2; (c) adding lactose and whey protein concentrate to mixture 2, thereby yielding mixture 3, wherein the amount of whey protein added is sufficient to provide about X kg of protein, said whey protein concentrate having an alpha-lactalbumin content of 28% to 40% and a beta-lactoglobulin content of 8% to 33% of total protein; (d) adding about 0.00789X kg taurine dissolved in hot water to mixture 3, thereby yielding mixture 4; (e) adding to mixture 4 alone or in combination, calcium carbonate, about 0.0243X kg; calcium hydroxide, about 0.00936X kg; potassium hydroxide, about 0.00511X kg; magnesium chloride, about 0.0181X kg; calcium chloride, about 0.0140X kg; potassium chloride, about 0.0197X kg; ferrous sulfate, about 0.00539X kg; about 0.00113X kg of a 1% potassium iodide triturate in lactose; 0.00893X kg of a 44.6% solution of zinc sulfate; about 0.0131X kg of a 2.5% solution of copper sulfate; about 0.0181X kg of a 2.5% solution of manganese sulfate, and about 0.000446X kg of a 0.3% sodium selenite triturate in potassium bicarbonate; thereby yielding mixture 5; (f) heating mixture 5 to 96 +/− 2° C.; (g) incubating mixture 5 at 96 +/− 2° C. for about 30 seconds; (h) cooling mixture 5 to 66 +/− 2° C; (i) homogenizing mixture 5; and (j) cooling the homogenized mixture 5 to 5-10° C. 18. The method of claim 17 wherein X is about 28 kg. 19. A method of increasing a plasma tryptophan level in an individual comprising administering to said individual a composition, said composition comprising an amount of bovine milk providing 1.0 to 1.2 grams of protein per 100 available kilocalories and an amount of a bovine whey material providing 1.0 to 1.2 grams of protein per 100 available kilocalories, said bovine whey material having an alpha-lactalbumin content of 28% to 40% and a beta-lactoglobulin content of 8% to 33% of total protein.
이 특허에 인용된 특허 (14)
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Pearce Robert J. (Beaumaris AUX), Enriched whey protein fractions and method for the production thereof.
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Slattery Charles W., Human infant formulas containing recombinant human alpha-lactalbumin and beta-casein.
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Sherwood Geoffrey (Dallas TX), Infant formula.
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Gaull Gerald E., Infant formula compositions and nutrition containing genetically engineered human milk proteins.
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Gaull Gerald E. (1107 Fifth Ave. New York NY 10028), Infant milk formula.
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Kuwata Tamotsu (Saitama JPX) Kaneko Tetsuo (Saitama JPX) Kojima Tadashi (Tokyo JPX) Kobayashi Toshitaka (Saitama JPX) Yamamoto Yoshiro (Tokyo JPX), Method for producing a formulated milk for infants analogous to human milk.
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Wilson, Jeffrey L., Nutritional formulation containing prebiotic substances.
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Woychik John H. (Lafayette Hill PA), Preparation of simulated human milk protein by low temperature microfiltration.
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de Rahm Olivier (La Tour-de-Peilz CHX), Preparation of whey products having reduced allergericity.
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Roger Loc (Rennes FRX) Maubois Jean-Louis (La Barre-Guibourg FRX) Brul Grard (Rennes FRX) Piot Michel (Rennes FRX), Process for obtaining an
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