New stable compositions comprising the combination of a topically active vasoconstrictor and a topically active anticholinergic drug are disclosed. Preferably, the composition comprises ipratropium or a salt thereof in combination with xylometazoline hydrochloride and a salt thereof. Upon topically
New stable compositions comprising the combination of a topically active vasoconstrictor and a topically active anticholinergic drug are disclosed. Preferably, the composition comprises ipratropium or a salt thereof in combination with xylometazoline hydrochloride and a salt thereof. Upon topically administering such compositions to a nasal mucosa in individuals suffering from the common cold the symptoms of rhinorrhea are significantly reduced.
대표청구항▼
The invention claimed is: 1. A method for the treatment of a condition selected from the group consisting of rhinitis and nasal congestion comprising administering to a mucosa of a human in need thereof a composition in the form of an aqueous solution comprising: (a) ipratropium bromide in an amoun
The invention claimed is: 1. A method for the treatment of a condition selected from the group consisting of rhinitis and nasal congestion comprising administering to a mucosa of a human in need thereof a composition in the form of an aqueous solution comprising: (a) ipratropium bromide in an amount of 1.2 mg per mL, (b) xylometazoline hydrochloride in an amount of 1 mg per mL, (c) disodium edetate in an amount of 0.5 mg per mL as a complex binder, (d) at least 10% water, and (e) 85% glycerol in an amount of 2.70% (w/v) as a humectant, wherein the solution has a pH of 4.5. 2. A method for the treatment of a condition selected from the group consisting of rhinitis and nasal congestion comprising administering to a mucosa of a human in need thereof a composition in the form of an aqueous solution comprising: (a) ipratropium bromide in an amount of 1.2 mg per mL, (b) xylometazoline hydrochloride in an amount of 1 mg per mL, (c) disodium edetate in an amount of 0.5 mg per mL as a complex binder, and (d) at least 10% water, wherein the solution has a pH of 4.5. 3. A method for the treatment of a condition selected from the group consisting of rhinitis and nasal congestion comprising administering to a mucosa of a human in need thereof a composition in the form of an aqueous solution comprising: (a) ipratropium bromide in an amount of 0.6 mg per mL, (b) xylometazoline hydrochloride in an amount of 1.0 mg per mL, (c) a complex binder selected from the group consisting of disodium edetate, calcium dinatrium edetate, dipotassium edetate, and trisodium edetate in an amount of 0.125 mg per mL, (d) at least 10% water, and (e) 85% glycerol in an amount of 27.3 mg per mL as a humectant, wherein the solution has a pH of 4.5. 4. A method for the treatment of a condition selected from the group consisting of rhinitis and nasal congestion comprising administering to a mucosa of a human in need thereof a composition in the form of an aqueous solution comprising: (a) ipratropium bromide in an amount of 0.600 mg, (b) xylometazoline hydrochloride in an amount of 0.500 mg, (c) disodium edetate in an amount of 0.500 mg as a complex binder, (d) purified water in an amount to result in a total volume of 1 mL, (e) 85% glycerol in an amount of 27.9 mg as a humectant, and (f) concentrated hydrochloric acid and sodium hydroxide in an amount to adjust the pH to 4.5. 5. The method according to claim 1, wherein the administration is to one or both nostril(s) for one to four times daily. 6. The method according to claim 2, wherein the administration is to one or both nostril(s) for one to four times daily. 7. The method according to claim 3, wherein the administration is to one or both nostril(s) for one to four times daily. 8. The method according to claim 4, wherein the administration is to one or both nostril(s) for one to four times daily. 9. The method according to claim 1, wherein the composition is a nasal composition. 10. The method according to claim 2, wherein the composition is a nasal composition. 11. The method according to claim 3, wherein the composition is a nasal composition. 12. The method according to claim 4, wherein the composition is a nasal composition.
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이 특허에 인용된 특허 (3)
Dikstein Shabtay (Jerusalem ILX), Method of the treatment of dry nose syndrome.
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