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Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured resp

Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response is provided.

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What is claimed is: 1. A method of calibrating an analyte sensor, comprising: applying a control signal to the analyte sensor; detecting a measured response to the control signal; determining a variance in the detected measured response; and estimating, with a processor, a sensor sensitivity based

What is claimed is: 1. A method of calibrating an analyte sensor, comprising: applying a control signal to the analyte sensor; detecting a measured response to the control signal; determining a variance in the detected measured response; and estimating, with a processor, a sensor sensitivity based on the variance in the detected measured response. 2. The method of claim 1 wherein the level of the control signal varies in time. 3. The method of claim 1 wherein the control signal includes a square wave signal. 4. The method of claim 3 wherein the square wave signal is applied to a poise voltage. 5. The method of claim 1 wherein detecting the measured response includes determining a work electrode current signal. 6. The method of claim 1 wherein the variance is determined based on comparing the difference between the beginning and end of the half duty cycle of the measured response to the control signal. 7. The method of claim 1 wherein estimating the sensor sensitivity includes retrieving a predetermined sensor sensitivity corresponding to the determined variance in the detected measured response. 8. The method of claim 1 further including determining a validity of the estimated sensor sensitivity. 9. The method of claim 1 further including determining analyte level based on the estimated sensor sensitivity. 10. The method of claim 1 wherein the sensor includes an analyte sensor. 11. An analyte sensor device, comprising: a processor configured to apply a control signal to the analyte sensor, detect a measured response to the control signal, determine a variance in the detected measured response, and estimate a sensor sensitivity based on the variance in the detected measured response. 12. The device of claim 11 wherein the processor is configured to vary the level of the control signal with time. 13. The device of claim 11 wherein the control signal includes a square wave signal. 14. The device of claim 13 wherein the processor is configured to apply the square wave signal to a poise voltage. 15. The device of claim 11 wherein the processor is configured to determine a work electrode current signal of an analyte sensor operatively coupled to the processor. 16. The device of claim 11 wherein the processor is configured to determine the variance based on comparing the difference between the beginning and end of the half duty cycle of the measured response to the control signal. 17. The device of claim 11 wherein the processor is configured to retrieve a predetermined sensor sensitivity corresponding to the determined variance in the detected measured response. 18. The device of claim 11 wherein the processor is operatively coupled to a data receiver unit configured to determine determining a validity of the estimated sensor sensitivity. 19. The device of claim 18 wherein the data receiver unit is configured to determine an analyte level based on the estimated sensor sensitivity. 20. The device of claim 11 wherein the processor is operatively coupled to an analyte sensor.