Method of treating depression, mood disorders and anxiety disorders using neuromodulation
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/00
출원번호
UP-0469669
(2006-09-01)
등록번호
US-7653433
(2010-02-24)
우선권정보
CA-2432810(2003-06-19)
발명자
/ 주소
Lozano, Andres M
Mayberg, Helen S
출원인 / 주소
Advanced Neuromodulation Systems, Inc.
대리인 / 주소
Acosta, Melissa
인용정보
피인용 횟수 :
22인용 특허 :
81
초록▼
The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site whi
The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.
대표청구항▼
We claim: 1. A method of treating a mood or anxiety disorder in a patient comprising: implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in or in direct contact with neural tissue of the gray and white matter inferior to the corpus callosum a
We claim: 1. A method of treating a mood or anxiety disorder in a patient comprising: implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in or in direct contact with neural tissue of the gray and white matter inferior to the corpus callosum and posterior to the anterior most portion of the genu of the corpus callosum; coupling the lead to a pulse generator; generating electrical pulses using a pulse generator; conducting the electrical pulses from the pulse generator through a stimulation lead; and applying the electrical pulses to stimulate neural tissue of the gray and white matter inferior to the corpus callosum and posterior to the anterior most portion of the genu of the corpus callosum of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively treats the mood or anxiety of the patient. 2. The method of claim 1, wherein the neural tissue comprises the subcallosal white matter and adjacent cortex. 3. The method of claim 2, wherein the neural tissue comprises the subcallosal white matter. 4. The method of claim 2, wherein the neural tissue includes the subgenual cingulate gyrus and surrounding white matter. 5. The method of claim 4, wherein the subgenual cingulate gyrus and surrounding white matter comprises Brodmann area 25. 6. The method of claim 5, wherein the subgenual cingulate gyrus and surrounding white matter comprises subgenual Brodmann area 24. 7. The method of claim 1 further comprising evaluating the patient to determine the effectiveness of the treatment. 8. The method of claim 7, wherein adjustments to parameters are made based upon the evaluation to increase the effectiveness of the treatment. 9. The method of claim 1, wherein after implantation the at least one electrode is positioned about 20 mm to about 40 mm anterior to the anterior commissure. 10. The method of claim 9, wherein after implantation the at least one electrode is positioned about 20 mm to about 30 mm anterior to the anterior commissure. 11. The method of claim 1, wherein the mood disorder is selected from the group consisting of major depressive disorder, and bipolar disorder. 12. The method of claim 1, wherein the anxiety disorder is selected from the group consisting of panic disorder, posttraumatic stress disorder, obsessive-compulsive disorder and phobic disorder. 13. The method of claim 1, wherein the mood disorder is major depressive disorder. 14. The method of claim 13, wherein the treatment for the major depressive disorder of the patient results in partial or complete remission of the disorder. 15. The method of claim 1, wherein the generating, conducting, and applying are performed on a chronic basis. 16. A method of treating depression, mood disorder and/or anxiety disorder in a patient comprising: implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in or in direct contact with neural tissue of the gray and white matter inferior to the rostrum and genu of the corpus callosum and about 20 to about 40 mm anterior to the anterior commissure; coupling the lead to a pulse generator; generating electrical pulses using a pulse generator; conducting the electrical pulses from the pulse generator through a stimulation lead; and applying the electrical pulses to stimulate neural tissue of the medial gray and white matter inferior to the rostrum and genu of the corpus callosum and about 20 to about 40 mm anterior to the anterior commissure of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively treats the depression, mood disorder and/or anxiety disorder of the patient. 17. The method of claim 16, wherein after implantation the at least one electrode is positioned about 20 mm to about 30 mm anterior to the anterior commissure. 18. The method of claim 16, wherein the neural tissue comprises the subcallosal white matter and adjacent cortex. 19. The method of claim 18, wherein the subcallosal white matter and adjacent cortex comprises Brodmann area 25. 20. The method of claim 18, wherein the at least one electrode is implanted within the subcallosal white matter. 21. The method of claim 19, wherein the at least one electrode is implanted within a white matter tract contiguous with Brodmann area 25. 22. A method of treating depression, mood disorder or anxiety disorder in a patient, comprising: implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in neural tissue about 0 mm to 10 mm below the intra-commissural line, about 2 mm to 14 mm from midline and about 20 to about 40 mm anterior to the anterior commissure; coupling the lead to a pulse generator; generating electrical pulses using the pulse generator; conducting the electrical pulses from the pulse generator through the stimulation lead; and applying the electrical pulses to stimulate the neural tissue of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively treats the depression, mood disorder or anxiety disorder of the patient. 23. The method of claim 22, wherein after implantation the at least one electrode is positioned about 20 mm to about 30 mm anterior to the anterior commissure. 24. The method of claim 22 further comprising identifying an approximate location to position the stimulation lead in the patient by utilizing an imaging system. 25. The method of claim 22, wherein the neural tissue comprises the gray and white matter of the subcallosal area that is inferior to the rostrum and genu of the corpus callosum including Brodmann area 25 and subgenual Brodmann area 24. 26. A method of treating depression, mood disorder or anxiety disorders in a patient, comprising: implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in direct contact with or directly in the subcallosal gyrus area including the surrounding white matter; generating electrical pulses using an implantable pulse generator (IPG) that is implanted within the patient; conducting the electrical pulses from the IPG through a stimulation lead; and applying the electrical pulses to stimulate neural tissue of the subcallosal gyrus area including the surrounding white matter of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively treats the depression, mood disorder and/or anxiety disorder of the patient. 27. The method of claim 26, wherein treating the patient's depression, mood disorder and/or anxiety disorder improves the patient's appetite. 28. A method of improving a patient's appetite, comprising: implanting a stimulation lead within the patient such that at least one electrode of the lead is positioned in direct contact with or directly in the subcallosal gyrus area including the surrounding white matter; generating electrical pulses using an implantable pulse generator (IPG) that is implanted within the patient; conducting the electrical pulses from the IPG through a stimulation lead; and applying the electrical pulses to stimulate neural tissue of the subcallosal gyrus area including the surrounding white matter of the patient utilizing the at least one electrode of the stimulation lead, wherein the applying the electrical pulses effectively improves the patient's appetite.
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