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Method of profiling gene expression in a human subject 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C12P-019/34
출원번호 UP-0803858 (2004-03-18)
등록번호 US-7662558 (2010-04-03)
발명자 / 주소
  • Liew, Choong-Chin
출원인 / 주소
  • GeneNews Corporation
대리인 / 주소
    Edwards Angell Palmer & Dodge LLP
인용정보 피인용 횟수 : 39  인용 특허 : 17

초록

The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which

대표청구항

I claim: 1. A method of profiling gene expression in a human subject, the method comprising: determining, for each gene of a set of genes, a level of RNA encoded by the gene in a blood sample of the subject, wherein the set comprises the genes identified as: 100 kDa coactivator; 10 kD protein (BC10

이 특허에 인용된 특허 (17)

  1. Albertsen Hans (Salt Lake City UT) Anand Rakesh (Cheshire UT GB2) Carlson Mary (Salt Lake City UT) Groden Joanna (Salt Lake City UT) Hedge Philip J. (Cheshire UT GB2) Joslyn Geoff (Salt Lake City UT), APC gene and nucleic acid probes derived therefrom.
  2. An Gang ; O'Hara S. Mark ; Ralph David ; Veltri Robert, Biomarkers and targets for diagnosis, prognosis and management of prostate disease.
  3. An Gang ; O'Hara S. Mark ; Ralph David ; Veltri Robert, Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer.
  4. Monia Brett P. ; Freier Susan M. ; Ecker David J., Compositions and methods for modulating .beta.-amyloid.
  5. Falb Dean A., Compositions and methods for the treatment and diagnosis of cardiovascular disease.
  6. Falb Dean A. ; Gimbrone ; Jr. Michael A., Compositions and methods for treatment and diagnosis of cardiovascular disease.
  7. Cocks, Benjamin G.; Stuart, Susan G.; Seilhamer, Jeffrey J., Compositions for the detection of blood cell and immunological response gene expression.
  8. Mordechai Eli ; Vojdani Aristo, Detection of chronic fatigue syndrome by increased apoptosis and cell cycle arrest of peripheral blood mononuclear cell.
  9. Ralph David ; An Gang ; O'Hara S. Mark ; Veltri Robert, Diagnosis of disease state using MRNA profiles in peripheral leukocytes.
  10. Schweighoffer Fabien,FRX ; Bracco Laurent,FRX ; Tocque Bruno,FRX, Differential Qualitative screening.
  11. Richard A. Shimkets, Genes and proteins predictive and therapeutic for stroke, hypertension, diabetes and obesity.
  12. Walker Michael G. ; Volkmuth Wayne ; Klingler Tod M. ; Azimzai Yalda ; Yue Henry, Genes associated with diseases of the kidney.
  13. Metzner Ernest K. ; Erion Mark D., Method and compounds for diagnosing coronary artery disease.
  14. Kevin M. Slawin ; Donald J. Tindall ; Charles Y. F. Young ; Mohammad Saeed Saedi ; Abhay Kumar ; Harry G. Rittenhouse ; Robert L. Wolfert, Method for detection of micrometastatic prostate cancer.
  15. Hirth Klaus Peter, Method for molecular diagnosis of tumor angiogenesis and metastasis.
  16. Chenchik Alex ; Jokhadze George ; Bibilashvilli Robert,RUX, Methods of assaying differential expression.
  17. Fan, Jian Bing; Chakravarti, Aravinda; Halushka, Marc Kenneth, Polymorphisms associated with hypertension.

이 특허를 인용한 특허 (39)

  1. Shimizu, Mamoru; Wada, Takeshi, Asymmetric auxiliary group.
  2. Shimizu, Mamoru; Wada, Takeshi, Asymmetric auxiliary group.
  3. Butler, David; Iwamoto, Naoki; Meena; Svrzikapa, Nenad; Verdine, Gregory L.; Zlatev, Ivan, Chiral control.
  4. Butler, David; Iwamoto, Naoki; Meena; Svrzikapa, Nenad; Verdine, Gregory L.; Zlatev, Ivan, Chiral control.
  5. Meena; Butler, David; Iwamoto, Naoki; Svrzikapa, Nenad; Verdine, Gregory L.; Zlatev, Ivan, Chiral design.
  6. Gemba, Takefumi, Chiral nucleic acid adjuvant.
  7. Gemba, Takefumi; Nagata, Ryoichi; Torikai, Yusuke, Chiral nucleic acid adjuvant having antitumor effect and antitumor agent.
  8. Gemba, Takefumi; Nagata, Ryoichi; Shiga, Ikumi, Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator.
  9. Chang, Sherman H., Diagnosis of melanoma and solar lentigo by nucleic acid analysis.
  10. Maier, Nicholas M.; Mertka, William L., Emergency location information gateway for public safety answering points (PSAPs) and method of use.
  11. DiPerna, Paul M, Flow regulating stopcocks and related methods.
  12. DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
  13. DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
  14. Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
  15. Michaud, Michael; Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
  16. Michaud, Michael; Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
  17. Verhoef, Erik T.; DiPerna, Paul M.; Rosinko, Mike; Williamson, Mark; Kruse, Geoffrey A.; Ulrich, Thomas R.; Lamb, Phil; Saint, Sean; Michaud, Michael; Trevaskis, William, Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
  18. Wada, Takeshi; Shimizu, Mamoru, Method for the synthesis of phosphorus atom modified nucleic acids.
  19. Wada, Takeshi; Shimizu, Mamoru, Method for the synthesis of phosphorus atom modified nucleic acids.
  20. Liew, Choong-Chin, Method of profiling gene expression in a healthy subject.
  21. Liew, Choong-Chin, Method of profiling gene expression in a subject having alzheimer's disease.
  22. Liew, Choong-Chin, Method of profiling gene expression in a subject having an infectious disease.
  23. Liew, Choong-Chin, Method of profiling gene expression in a subject having colorectal cancer.
  24. Liew, Choong-Chin, Method of profiling gene expression in a subject having diabetes.
  25. Liew, Choong-Chin, Method of profiling gene expression in a subject having disease.
  26. Liew, Choong-Chin, Method of profiling gene expression in a subject having heart failure.
  27. Liew, Choong-Chin, Method of profiling gene expression in a subject having prostate cancer.
  28. Liew, Choong-Chin, Method of profiling gene expression in a subject undergoing a treatment.
  29. Scott, III, Linzy O., Methods and compositions for treating thyroid-related medical conditions with reduced folates.
  30. Scott, III, Linzy O., Methods and compositions for treating thyroid-related medical conditions with reduced folates.
  31. Scott, III, Linzy O., Methods and compositions for treating thyroid-related medical conditions with reduced folates.
  32. Verdine, Gregory L.; Meena; Iwamoto, Naoki; Butler, David Charles Donnell, Methods for the synthesis of functionalized nucleic acids.
  33. Verdine, Gregory L.; ., Meena; Iwamoto, Naoki, Nucleic acid prodrugs and methods of use thereof.
  34. DiPerna, Paul M., Slideable flow metering devices and related methods.
  35. Brown, David, Solute concentration measurement device and related methods.
  36. Rosinko, Michael J.; Kruse, Geoffrey A.; Harris, Paul, System and method for detecting occlusions in an infusion pump.
  37. Metzmaker, Thomas; Saint, Sean; Michaud, Michael; Rosinko, Michael J.; Swanson, Vance, Systems including vial adapter for fluid transfer.
  38. Creasey, Graham H.; Toong, Hoo-Min, Topical neurological stimulation.
  39. DiPerna, Paul M., Two chamber pumps and related methods.
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