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Systems and methods involve automatic activation, de-activation or modification of therapies or other medical processes based on brain state. A medical system includes a sensor system having one or more sensors configured to sense signals related to the brain state of the patient. A brain state anal

Systems and methods involve automatic activation, de-activation or modification of therapies or other medical processes based on brain state. A medical system includes a sensor system having one or more sensors configured to sense signals related to the brain state of the patient. A brain state analyzer detects various brain states, including sleep stage and/or brain seizures. A controller uses the brain state detection information to control a medical system configured to perform at least one respiratory or cardiac process. Methods involve sensing signals related to brain state and determining the brain state of a patient based on the sensed signals. At least one respiratory or cardiac medical process is controlled based on the patient's brain state.

대표청구항 ▼

What is claimed is: 1. A system, comprising: a housing configured to be implanted; a sensor system having one or more sensors configured to sense brain activity; a brain activity detector coupled to the sensor system and configured to determine a brain state based on signals received from the senso

What is claimed is: 1. A system, comprising: a housing configured to be implanted; a sensor system having one or more sensors configured to sense brain activity; a brain activity detector coupled to the sensor system and configured to determine a brain state based on signals received from the sensor system; a medical system comprising a cardiac rhythm management device and configured to perform at least one respiratory or cardiac process; and a controller coupled to the brain activity detector and the medical system, the controller configured to execute program instruction stored in memory to cause the medical system to activate, de-activate or adjust the at least one cardiac or respiratory process based on the brain state, including executing stored instructions to modify a cardiac rhythm management therapy to address cardiac rhythm disturbances associated with an abnormal brain state based on identification of the abnormal brain state by at least one of the controller and the brain activity detector, wherein at least one of the sensor system and the controller are at least partially housed within the housing. 2. The system of claim 1, wherein the sensor system comprises at least one EEG sensor and the brain activity detector is configured to execute stored program instructions to determine the brain state based on EEG signals sensed by the EEG sensor. 3. The system of claim 1, wherein the sensor system comprises at least one EEG sensor and at least one EMG sensor, and the brain activity detector is configured to execute stored program instruction to determine the brain state based on EEG signals and EMG signals. 4. The system of claim 1, wherein at least one of the brain activity detector and the controller is configured to execute stored program instructions to determine relative sleep deepness, and the controller is configured to execute stored program instructions to decrease intensity of a sleep-disordered breathing therapy delivered by the medical system based on detection of a deeper level of sleep relative to a lighter level of sleep. 5. The system of claim 4, wherein at least one of the brain activity detector and the controller is configured to execute stored program instructions to identify at least REM sleep, sleep stage 3, and sleep state 4, and the controller is configured to execute stored program instructions to at least one of decrease and terminate the sleep-disordered breathing therapy based on detection of at least one of sleep stage 3, sleep stage 4, and sleep stage 4. 6. The system of claim 1, wherein the medical system comprises an external respiratory therapy device configured to deliver a disordered breathing therapy. 7. The system of claim 1, wherein the sensor system is housed within the housing and configured to sense EEG signals. 8. The system of claim 1, wherein the cardiac rhythm management device is configured to deliver a sleep-disordered breathing therapy comprising cardiac stimulation pulses and the controller is configured to execute stored program instruction to activate, de-activate, or adjust the sleep-disordered breathing therapy delivered by the medical system based on the brain state. 9. The system of claim 1, wherein the medical system further comprises an external respiratory therapy device, the controller is disposed in the cardiac rhythm management circuitry device or the external respiratory therapy device, and the controller is configured to execute stored program instructions to control at least one therapy function for each of the cardiac rhythm management device and the external respiratory therapy device. 10. The system of claim 1, wherein the sensor system is configured to sense impedance signals and the brain activity detector is configured execute program instructions to determine the brain state using the impedance signals. 11. The system of claim 1, wherein the housing further houses cardiac pacing circuitry configured to deliver a cardiac pacing therapy, at least one of the brain activity detector and the controller is configured to execute stored program instructions to identify proarrhythmic sleep periods, and the controller is configured to execute stored program instructions to cause the cardiac pacing circuitry to deliver atrial overdrive pacing during identified proarrhythmic sleep periods. 12. A method, comprising: sensing signals indicative of brain activity, including sensing signals indicative of seizure; determining a brain state of a patient based on the sensed signals; and controlling at least one of a respiratory or a cardiac medical process based on brain state, including activating, de-activating or adjusting arrhythmia therapy based on the signals indicative of seizure, wherein at least one of sensing, determining, and controlling are performed by implanted components. 13. The method of claim 12, wherein sensing the signals indicative of brain state comprises sensing EEG signals and controlling the at least one of the respiratory process or the cardiac medical process comprises controlling at least one of a cardiac pacing therapy or a xPAP therapy. 14. The method of claim 12, wherein: sensing signals related to brain state comprises determining a sleep stage of the patient; and controlling the at least one medical process comprises activating, de-activating or adjusting a sleep disordered breathing therapy based on the patient's sleep stage. 15. The method of claim 12, wherein sensing signals comprises sensing at least one EMG signal to detect an effect of neural stimulation. 16. The method of claim 12, wherein sensing signals comprises sensing EEG signals and controlling the at least one medical process comprises activating, de-activating or adjusting a respiratory therapy delivered by an implantable cardiac pacing device. 17. The method of claim 12, wherein controlling the at least one medical process comprises activating, de-activating or adjusting a cardiac pacing therapy. 18. A system, comprising: a housing configured to be implanted; a sensor system having one or more sensors configured to sense brain activity; a brain activity detector coupled to the sensor system and configured to determine a brain state based on signals received from the sensor system; a medical system comprising an implantable cardiac rhythm management device configured to deliver a sleep-disordered breathing therapy comprising cardiac stimulation pulses; and a controller coupled to the brain activity detector and the medical system, the controller configured to execute program instruction stored in memory to cause the medical system to activate, de-activate or adjust the sleep-disordered breathing therapy delivered by the medical system based on the brain state, wherein at least one of the sensor system and the controller are at least partially housed within the housing. 19. A system, comprising: a housing configured to be implanted; a sensor system having one or more sensors configured to sense brain activity; a brain activity detector coupled to the sensor system and configured to determine a brain state based on signals received from the sensor system; a medical system comprising a cardiac rhythm management device and an external respiratory therapy device configured to perform at least one respiratory or cardiac process; and a controller coupled to the brain activity detector and the medical system, the controller configured to execute program instruction stored in memory to cause the medical system to control at least one therapy function for each of the cardiac rhythm management device and the external respiratory therapy device, wherein the controller is disposed in the cardiac rhythm management circuitry device or the external respiratory therapy device. 20. A system, comprising: a housing configured to be implanted; a sensor system having one or more sensors configured to sense brain activity; a brain activity detector coupled to the sensor system and configured to determine a brain state based on signals received from the sensor system; a medical system comprising cardiac pacing circuitry disposed in the housing configured to deliver a cardiac pacing therapy; and a controller coupled to the brain activity detector and the medical system, the controller configured to execute program instruction stored in memory to cause the medical system to activate, de-activate or adjust the at least one cardiac or respiratory process based on the brain state, wherein at least one of the brain activity detector and the controller is configured to execute stored program instructions to identify proarrhythmic sleep periods and the controller is configured to execute stored program instructions to cause the cardiac pacing circuitry to deliver atrial overdrive pacing during identified proarrhythmic sleep periods and wherein at least one of the sensor system and the controller are at least partially housed within the housing.