초록 ▼

The invention provides methods, systems and apparatus for the metered transport of fine powders into receptacles. According to one exemplary method, the fine powder is first fluidized. At least a portion of the fluidized fine powder is then captured. The captured fine powder is then transferred to a

The invention provides methods, systems and apparatus for the metered transport of fine powders into receptacles. According to one exemplary method, the fine powder is first fluidized. At least a portion of the fluidized fine powder is then captured. The captured fine powder is then transferred to a receptacle, with the transferred powder being sufficiently uncompacted so that it may be dispersed upon removal from the receptacle.

대표청구항 ▼

What is claimed is: 1. An apparatus for filling a unit dose receptacle with an aerosolizable powder medicament, the apparatus comprising: a supply of aerosolizable powder medicament, the powder medicament comprising particles having a mean size less than 10 microns; a chamber sized to contain a uni

What is claimed is: 1. An apparatus for filling a unit dose receptacle with an aerosolizable powder medicament, the apparatus comprising: a supply of aerosolizable powder medicament, the powder medicament comprising particles having a mean size less than 10 microns; a chamber sized to contain a unit dose of the aerosolizable powder medicament, wherein the chamber is sized to contain from about 1 mg to 20 mg of the aerosolizable powder; and a powder fluidizer that fluidizes the powder medicament so that the particles may be captured in the chamber; wherein a vacuum may be applied to the chamber to assist in capturing powder and pressure may be applied to the chamber to eject captured powder from the chamber and into a unit dose receptacle in a manner where the powder may later be aerosolized from the unit dose receptacle. 2. An apparatus according to claim 1 wherein the chamber is in a moveable member that is moveable between a powder capturing position and a powder ejecting position. 3. An apparatus according to claim 2 wherein the moveable member is a rotatable member. 4. An apparatus according to claim 3 wherein the rotatable member comprises a plurality of chambers. 5. An apparatus according to claim 1 further comprising a controller capable of causing the vacuum or the pressure to be applied to the chamber. 6. An apparatus according to claim 1 wherein the powder fluidizer comprises a mechanism which agitates the particles. 7. An apparatus according to claim 1 wherein the powder fluidizer comprises a mechanism which vibrates to agitate the particles. 8. An apparatus according to claim 1 wherein the powder fluidizer allows the particles to be captured in the chamber without the creation of substantial voids and without excessive compaction of the particles. 9. An apparatus according to claim 1 wherein the powder fluidizer comprises a sieve. 10. An apparatus according to claim 9 wherein the sieve contains apertures with a mean size in the range from about 0.05 mm to 6 mm. 11. An apparatus according to claim 9 wherein the powder fluidizer comprises an additional sieve. 12. An apparatus according to claim 1 further comprising a unit dose receptacle into which the chamber may eject a unit dose of the powder medicament. 13. An apparatus according to claim 1 further comprising an upstream hopper in communication with the supply of powder medicament. 14. An apparatus according to claim 13 wherein the upstream hopper contains a means for fluidizing the powder medicament to control the flow of the powder medicament from the upstream hopper to the supply of powder medicament. 15. An apparatus according to claim 14 wherein the means for fluidizing the powder medicament in the upstream hopper comprises a translatable member having apertures with a mean size in the range from about 0.2 mm to 10 mm. 16. An apparatus according to claim 15 wherein the translatable member comprises a sieve. 17. An apparatus according to claim 13 wherein a translatable member having apertures with a mean size in the range from about 0.2 mm to 10 mm is in communication with the upstream hopper to control the flow of the powder medicament from the upstream hopper. 18. An apparatus according to claim 1 wherein the chamber is sized to contain from 2 mg to 10 mg of the aerosolizable powder. 19. An apparatus according to claim 12 wherein the unit dose receptacle comprises a blister pack. 20. An apparatus according to claim 12 wherein the unit dose receptacle comprises a capsule. 21. An apparatus for filling a unit dose receptacle with an aerosolizable powder medicament, the apparatus comprising: a supply of aerosolizable powder medicament, the powder medicament comprising particles having a mean size less than 10 microns; a chamber sized to contain a unit dose of the aerosolizable powder medicament; and a powder fluidizer that fluidizes the powder medicament so that the particles may be captured in the chamber, wherein the powder fluidizer comprises a mechanism which vibrates to agitate the particles; wherein a vacuum may be applied to the chamber to assist in capturing powder and pressure may be applied to the chamber to eject captured powder from the chamber and into a unit dose receptacle in a manner where the powder may later be aerosolized from the unit dose receptacle.